Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease

Olazarán, Javier; Múñiz, Rubén; Reisberg, Barry; Peña-Casanova, Jordi; Ser, Teodoro del; Cruz-Jentoft, Alfonso J.; Serrano, P. Salgado; Navarro, Elisa; Rocha, M. L. García de la; Frank, Ana; Galiano, M. L.; Fernández-Bullido, Y.; Serra, José Antonio; González-Salvador, Ma Teresa; Sevilla, C.

doi:10.1212/01.wnl.0000147478.03911.28

Cited by 273 publications

(228 citation statements)

References 33 publications

Supporting

Mentioning

200

Contrasting

Unclassified

Order By: Relevance

“…Given the relative lack of tests and growing importance of such measures, it is clear that the development of ecologically valid tests would benefit rehabilitation research as well as the general field of Neuropsychology. 5,7,15,16,17,18,24,25,27,30,31,33 12 Narrative memory (other) 3,23,28,30 18,23,26,33, 15,21,22,30,31,33 6 Rivermead Behavioural Memory Test (RBMT) 7,8,16,17,26,27,31,33,34 3,7,23,30,31,36 1,3,4,5,15,28,29,32 1 The ...…”

Section: Methodological Challenge 4: Outcome Measuresmentioning

confidence: 99%

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Hampstead

Gillis

Stringer

2013

J Int Neuropsychol Soc

View full text Add to dashboard Cite

Several recent reviews have suggested that cognitive rehabilitation may hold promise in the treatment of memory deficits experienced by patients with mild cognitive impairment. In contrast to the previous reviews that mainly focused on outcome, the current review examines key methodological challenges that are critical for designing and interpreting research studies and translating results into clinical practice. Using methodological details from 36 studies, we first examine diagnostic variability and how the use of cutoffs may bias samples toward more severely impaired patients. Second, the strengths and limitations of several common rehabilitative techniques are discussed. Half of the reviewed studies used a multi-technique approach that precludes the causal attribution between any specific technique and subsequent improvement. Third, there is a clear need to examine the dose-response relationship since this information was strikingly absent from most studies. Fourth, outcome measures varied widely and frequently depended on neuropsychological tests with little theoretical justification or ecological relevance. Fifth, we discuss how the variability in each of these other four areas complicates efforts to examine training generalization. Overall, future studies should place greater emphasis on ecologically relevant treatment approaches and outcome measures and we propose a hierarchical model that may aid in this pursuit. (JINS, 2014, 20, 135-151)

show abstract

Section: Methodological Challenge 4: Outcome Measuresmentioning

confidence: 99%

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Hampstead

Gillis

Stringer

2013

J Int Neuropsychol Soc

View full text Add to dashboard Cite

show abstract

“…17 They are also a common reason for institutionalization of people with dementia and they increase the burden and stress of caregivers. 55,57,60 Nonpharmacologic Interventions Nonpharmacologic interventions are recommended as the most appropriate initial strategy for managing inappropriate behaviors in dementia because (1) they address the psychosocial/environmental underlying reason for the behavior, and (2) they avoid the limitations of pharmacologic interventions, namely, adverse side effects, drug-drug interactions, and limited efficacy. 15,17,61 Increased involvement of caregivers often has a secondary benefit of providing overburdened caregivers with an opportunity to receive support, information, and skills.…”

Section: Managing Mood Disorders and Behavior Problemsmentioning

confidence: 99%

Guidelines for the Management of Cognitive and Behavioral Problems in Dementia

Sadowsky¹,

Galvin²

2012

The Journal of the American Board of Family Medicine

117

View full text Add to dashboard Cite

Family physicians play a crucial role in the management and ongoing care of patients with Alzheimer disease (AD). This article reviews the effects of nonpharmacologic and pharmacologic interventions on the functional abilities and behavior of patients with dementia and how these can be implemented into clinical practice. Nonpharmacologic interventions are recommended as the initial strategy for managing problematic behaviors. Strategies for improving behavior include ensuring that the patient's environment is safe, calm, and predictable; removing environmental stressors; and identifying and avoiding situations that agitate or frighten the patient. Simple interventions include redirecting and refocusing the patient, increasing social interaction, establishing regular sleep habits, eliminating sources of conflict and frustration, and establishing rewards for successes. The effectiveness of long-term behavioral management is largely dependent on the caregiver; as such, it is important to assess the role and needs of the caregiver.Because currently available therapies cannot reverse the pathologic processes of AD, the primary objective of pharmacotherapy is to preserve cognitive and functional ability, minimize behavioral disturbances, and slow disease progression. Cholinesterase inhibitors represent first-line therapy for patients with mild to moderate AD, whereas a glutamate N-methyl D-aspartate antagonist is used in the treatment of moderate to severe AD. Looking forward, there are a number of therapies in development aimed at modifying the disease course; these include amyloid-lowering drugs, -based and neuroprotective approaches, acetylcholine agonists, and mitochondrial inhibitors.

show abstract

“…Olazarán and co-workers [56] only, investigating both AD and MCI patients, found better cognitive outcomes after cognitive stimulations in patients with low, compared with those with high educational level. This surprising result is likely due to the fact that in patients with high CR is needed accumulate more AD neuropathology to show same clinical symptoms of patients with low CR.…”

Section: Discussionmentioning

confidence: 98%

“…This surprising result is likely due to the fact that in patients with high CR is needed accumulate more AD neuropathology to show same clinical symptoms of patients with low CR. The Authors [56] concluded that patients with high CR were less able to learn new generalizable strategies useful to improve cognitive performances. However, further studies assessing relationship between different CR levels and non-pharmacological treatments seem to be necessary and desirable in the immediate future.…”

Section: Discussionmentioning

confidence: 99%

Cognitive reserve: the evolution of the conceptual framework

Serra¹,

Caltagirone²,

Bozzali³

2017

J Syst Integr Neurosci

View full text Add to dashboard Cite

Brain and Cognitive reserve concept is a theoretical general framework introduced to explain individual differences to withstand brain damages. Several behavioural and neuroimaging studies support the evidence that lifestyles act on brain plasticity modulating the impact of neurological insults. However, once that AD is clinically evident, the protective benefits of premorbid experience are assumed to be substantially decreased. This review presents an overview of the principal literature focused on reserve mechanisms. The evolution of the conceptual framework is considered, passing from brain and cognitive to neural reserve's hypothesis. Interactions between reserve mechanisms and AD-related biomarkers are reported. In particular this review is focussed on the neuroimaging (MRI) studies. MRI provides the opportunity to investigate in vivo structural and functional brain changes. Several studies reported here assessed the impact of reserves on brain resilience. Literature supports the hypothesis that reserves impact on neurodegenerative process in the early phase of AD. Moreover, studies fit with the existence of a "neural reserve", characterised by specific neural networks and their efficiency. It remains to be demonstrated whether interventions later in life can modulate this brain resilience.

show abstract

Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease

Abstract: A long-term CMI in ChEI-treated early Alzheimer disease patients produced additional mood and cognitive benefits.

Cited by 273 publications

References 33 publications

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Guidelines for the Management of Cognitive and Behavioral Problems in Dementia

Cognitive reserve: the evolution of the conceptual framework

Contact Info

Product

Resources

About