Benefits of Dietary Management in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Wang, Shurui; Yang, Ting; Qiang, Wanmin; Shen, Aomei; Zhao, Zihan; Liu, Xiaofeng

doi:10.1080/01635581.2021.1957129

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…Meta-analyses of clinical trials assessing regular consumption of plant foods and/or plant-derived molecules on the BC risk point to beneficial effects in the population (Farvid et al, 2021;Poorolajal et al, 2021). Other meta-analyses revealed that dietary management in BC patients based on vegetable and fibre intake provides useful lifestyle intervention against BC development (Wang et al, 2022). Despite constant progress in the advancement of anti-cancer strategies, the development of cancer resistance remains the main reason for BC-related mortality.…”

Section: Discussionmentioning

confidence: 99%

Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma

Kubatka,

Mazurakova,

Koklesova

et al. 2024

Front. Pharmacol.

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Introduction: Based on extensive data from oncology research, the use of phytochemicals or plant-based nutraceuticals is considered an innovative tool for cancer management. This research aimed to analyze the oncostatic properties of Salvia officinalis L. [Lamiaceae; Salviae officinalis herba] using animal and in vitro models of breast carcinoma (BC).Methods: The effects of dietary administered S. officinalis in two concentrations (0.1%/SAL 0.1/and 1%/SAL 1/) were assessed in both syngeneic 4T1 mouse and chemically induced rat models of BC. The histopathological and molecular evaluations of rodent carcinoma specimens were performed after the autopsy. Besides, numerous in vitro analyses using two human cancer cell lines were performed.Results and Conclusion: The dominant metabolites found in S. officinalis propylene glycol extract (SPGE) were representatives of phenolics, specifically rosmarinic, protocatechuic, and salicylic acids. Furthermore, the occurrence of triterpenoids ursolic and oleanolic acid was proved in SPGE. In a mouse model, a non-significant tumor volume decrease after S. officinalis treatment was associated with a significant reduction in the mitotic activity index of 4T1 tumors by 37.5% (SAL 0.1) and 31.5% (SAL 1) vs. controls (set as a blank group with not applied salvia in the diet). In addition, salvia at higher doses significantly decreased necrosis/whole tumor area ratio by 46% when compared to control tumor samples. In a rat chemoprevention study, S. officinalis at a higher dose significantly lengthened the latency of tumors by 8.5 days and significantly improved the high/low-grade carcinomas ratio vs. controls in both doses. Analyses of the mechanisms of anticancer activities of S. officinalis included well-validated prognostic, predictive, and diagnostic biomarkers that are applied in both oncology practice and preclinical investigation. Our assessment in vivo revealed numerous significant changes after a comparison of treated vs. untreated cancer cells. In this regard, we found an overexpression in caspase-3, an increased Bax/Bcl-2 ratio, and a decrease in MDA, ALDH1, and EpCam expression. In addition, salvia reduced TGF-β serum levels in rats (decrease in IL-6 and TNF-α levels were with borderline significance). Evaluation of epigenetic modifications in rat cancer specimens in vivo revealed a decline in the lysine methylations of H3K4m3 and an increase in lysine acetylation in H4K16ac levels in treated groups. Salvia decreased the relative levels of oncogenic miR21 and tumor-suppressive miR145 (miR210, miR22, miR34a, and miR155 were not significantly altered). The methylation of ATM and PTEN promoters was decreased after S. officinalis treatment (PITX2, RASSF1, and TIMP3 promoters were not altered). Analyzing plasma metabolomics profile in tumor-bearing rats, we found reduced levels of ketoacids derived from BCAAs after salvia treatment. In vitro analyses revealed significant anti-cancer effects of SPGE extract in MCF‐7 and MDA-MB-231 cell lines (cytotoxicity, caspase‐3/-7, Bcl‐2, Annexin V/PI, cell cycle, BrdU, and mitochondrial membrane potential). Our study demonstrates the significant chemopreventive and treatment effects of salvia haulm using animal or in vitro BC models.

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Section: Discussionmentioning

confidence: 99%

Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma

Kubatka,

Mazurakova,

Koklesova

et al. 2024

Front. Pharmacol.

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“…Breast Cancer-diets high in fruits and vegetables. Increase fiber intake and vegetable servings 9 Colorectal Cancer-to consume fewer high-fat foods, limit intake of red meats, eat more vegetables, Fruits, and whole grains.…”

Section: Recommendations For Specific Cancer Typesmentioning

confidence: 99%

The need for standardized dietary guidelines for cancer patients - with review of literature from governing bodies

Kulkarni

2023

JDPO

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Dietary advices in the form of dietary guidelines help immensely in the management of health and disease, more so in the management of cancer patient. The objective of this study is to emphasize the need for standardized dietary guidelines which will guide the cancer patients and the medical fraternity involved in the management of cancer patient. Thorough search was done from recognized authorities for the available dietary guidelines for cancer patients. We also performed literature search with the use of PubMed, and Google Scholar as our database articles citing the benefits of dietary intervention in cancer management. Only the guidelines and dietary advices in the management of cancer patients which were given by the authorized bodies were considered. The dietary guidelines for cancer patients that we found after thorough search are very few. These guidelines have remained the same for decades now and need revival. There is a strong need for standardized dietary advices given by the concerned authorities to guide the medical fraternity to help to support the cancer patients in a better and confident way. More and more studies are required to standardize the dietary requirements during cancer management. The process, though herculean, can begin with simple and short guidelines for the dietary management of common health concerns during cancer treatment. With the help of outcomes of larger studies in this domain, more appropriate guidelines can be formulated.

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Effectiveness of dietetic care for cancer survivors in the primary care setting: A systematic review and meta-analysis of randomized controlled trials

Ryding,

Mitchell,

Rigby

et al. 2024

J Cancer Surviv

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Purpose Nutrition plays an important role in cancer survivorship. This systematic review and meta-analysis aim to critically assess and quantify the effectiveness of nutrition care interventions provided by dietitians to survivors who have completed treatment for cancer. Methods A systematic review of randomized controlled trials (RCTs) published from January 2004 to November 2023 reporting the effectiveness of primary care dietetic interventions with adult cancer survivors was conducted. PubMed, Scopus, CINAHL, Embase, ProQuest and PsycINFO databases were searched for key terms. Meta-analyses were conducted where there were sufficient studies of the same cancer type and outcomes. Results Twelve RCTs representing 1138 cancer survivors (519 breast cancer; 75 prostate cancer; 544 colorectal cancer) were included. Primary outcome measures included weight loss (n = 6), quality of life (n = 2), reducing lymphedema-related arm volume (n = 2), nutritional status (n = 1) and increasing fruit and vegetable intake (n = 1). Weight loss was observed in studies where this was the primary outcome. Results for quality of life varied. Meta-analyses of RCTs with breast cancer survivors showed that dietitian intervention achieved a mean of 3.7 kg greater intentional weight loss and 2.3% greater body fat decrease than control (p < 0.0001). Conclusions This study provides evidence for the effectiveness of primary care dietetic interventions by dietitians with cancer survivors, particularly with respect to intentional weight and fat loss in breast cancer survivors. Implications for cancer survivors Dietitians can play a key role in managing weight and improving long term health outcomes and prognosis for cancer survivors beyond the acute care setting.

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Benefits of Dietary Management in Breast Cancer Patients: A Systematic Review and Meta-Analysis

Cited by 5 publications

References 45 publications

Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma

Salvia officinalis L. exerts oncostatic effects in rodent and in vitro models of breast carcinoma

The need for standardized dietary guidelines for cancer patients - with review of literature from governing bodies

Effectiveness of dietetic care for cancer survivors in the primary care setting: A systematic review and meta-analysis of randomized controlled trials

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