Benefits of Exercise Training in Multiple Sclerosis

Motl, Robert W.; Sandroff, Brian M.

doi:10.1007/s11910-015-0585-6

Cited by 251 publications

(226 citation statements)

References 68 publications

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“…Multiple sclerosis (MS) is a chronic, immune-mediated disease of the central nervous system (CNS) [1,2] that frequently results in pathological changes in the visual pathways with resulting vision morbidity. The anterior visual pathway, particularly the retinal ganglion cells (RGCs) that comprise the optic nerve, is commonly affected in MS, both acutely through optic neuritis (ON) and chronically with retinal ganglion cell atrophy, which can occur independently from ON [3].…”

Section: Introductionmentioning

confidence: 99%

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Bhaduri

Nolan

Shelton

et al. 2016

Biomed. Opt. Express

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Although retinal vasculitis is common in multiple sclerosis (MS), it is not known if MS is associated with quantitative abnormalities in retinal blood vessels (BVs). Optical coherence tomography (OCT) is suitable for examining the integrity of the anterior visual pathways in MS.In this paper we have compared the size and number of retinal blood vessels in patients with MS, with and without a history of optic neuritis (ON), and control subjects from the cross-sectional retinal images from OCT. Blood vessel diameter (BVD), blood vessel number (BVN), and retinal nerve fiber layer thickness (RNFL T ) were extracted from OCT images collected from around the optic nerves of 129 eyes (24 control, 24 MS + ON, 81 MS-ON) of 71 subjects. Associations between blood vessel metrics, MS diagnosis, MS disability, ON, and RNFL T were evaluated using generalized estimating equation (GEE) models. MS eyes had a lower total BVD and BVN than control eyes. The effect was more pronounced with increased MS disability, and persisted in multivariate models adjusting for RNFL T and ON history. Twenty-nine percent (29%) of MS subjects had fewer retinal blood vessels than all control subjects. MS diagnosis, disability, and ON history were not associated with average blood vessel size. The relationship between MS and lower total BVD/BVN is not accounted for by RNFL T or ON. Further study is needed to determine the relationship between OCT blood vessel metrics and qualitative retinal blood vessel abnormalities in MS. Huang, "Optical coherence tomography angiography of optic nerve head and parafovea in multiple sclerosis," Br. J. Ophthalmol. 98(10),

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Section: Introductionmentioning

confidence: 99%

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Bhaduri

Nolan

Shelton

et al. 2016

Biomed. Opt. Express

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“…Research establishing the benefits of physical activity for people with MS is burgeoning. 9,10 However, there are still gaps in research aiming to identify effective methods for broadly disseminating evidencebased physical activity interventions. Strategies to address these gaps are also relevant to falls prevention.…”

Section: Sensory Integrationmentioning

confidence: 99%

Drawing on Related Knowledge to Advance Multiple Sclerosis Falls-Prevention Research

Ploughman¹,

Deshpande²,

Latimer-Cheung³

et al. 2014

International Journal of MS Care

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There is much to be learned from falls-related research outside the field of multiple sclerosis (MS), as well as from work within the MS field but not specific to falls or falls prevention. This article describes three examples of such bodies of work that have potential to broaden approaches to falls-prevention research: 1) sensory components of postural control among older adults, 2) lessons learned from physical activity promotion among people with spinal cord injury (SCI), and 3) aging among people with MS. Age-related deterioration in visual, vestibular, and somatosensory systems or in sensory integration can adversely affect postural control and can contribute to falls in older people. Sensory-specific interventions designed for improving balance in older people could be adapted for preventing falls in individuals with MS. Spinal Cord Injury (SCI) Action Canada's strategy for disseminating physical activity promotion interventions for adults with SCI has been successful and widely accepted by community partners. Many of the peer-based interventions developed by SCI Action Canada are potentially relevant and could be adapted to the MS population for both physical activity promotion and falls prevention. Considering that older people with MS constitute a growing proportion of the MS population and over 70% of older people with MS report moderate to extreme balance problems, falls prevention should be one of the key components, particularly for MS management in older or more disabled groups. Overall, given people's different ages, symptoms, strengths, and barriers, a tailored MS falls-prevention intervention that includes peer/caregiver support is critical. Int J MS Care. 2014;16:163-170.

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“…10 Finally, Sutliff et al 1 raise a concern regarding reimbursement due to misinterpretation of this review. We emphasize that this is an SR 2 without practice recommendations.…”

mentioning

confidence: 96%

Rehabilitation in multiple sclerosis: Commentary on the recent AAN systematic review

et al. 2017

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Benefits of Exercise Training in Multiple Sclerosis

Cited by 251 publications

References 68 publications

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Detection of retinal blood vessel changes in multiple sclerosis with optical coherence tomography

Drawing on Related Knowledge to Advance Multiple Sclerosis Falls-Prevention Research

Rehabilitation in multiple sclerosis: Commentary on the recent AAN systematic review

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