Benefits of Hesperidin for Cutaneous Functions

Man, Mao‐Qiang; Yang, Bin; Elias, Peter M.

doi:10.1155/2019/2676307

Cited by 106 publications

(66 citation statements)

References 135 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hesperidin was also proved as a potent anti-photoageing factor, through regulation of metalloproteinases MMP-9 via mitogen activation protein kinase (MAPK) signaling pathways. In the same study, Lee and colleagues [ 19 ] approved the positive effect of the hesperidin on wrinkle depth on a mouse dorsal skin model, and reduction in UVB-induced hydration changes and trans-epidermal water loss [ 20 ]. Different studies demonstrate accelerated cutaneous diabetic or venous wounds healing and ameliorate skin epidermal barrier function already after 7 days of HSD application [ 20 ].…”

Section: Introductionmentioning

confidence: 99%

New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

et al. 2020

View full text Add to dashboard Cite

Hesperidin, a secondary orange (Citrus sinensis) metabolite, was extracted from orange bagasse. No organic solvents or additional energy consumption were used in the clean and sustainable process. Hesperidin purity was approximately 98% and had a yield of 1%. Hesperidin is a known supplement due to antioxidant, chelating, and anti-ageing properties. Herein, hesperidin application to eliminate dark eye circles, which are sensitive and thin skin regions, was studied. In addition, the proposed method for its aqueous extraction was especially important for human consumption. Further, the most effective methods for hesperidin nanonization were explored, after which the nanoemulsions were incorporated into a cream formulation that was formulated for a tropical climate. Silky cream formulations (oil in water) were tested in vitro on artificial 3D skin from cultured cells extracted from skin residues after plastic surgery. The proposed in vitro assay avoided tests of the different formulations in human volunteers and animals. It was shown that one of the nanonized hesperidin formulations was the most skin-friendly and might be used in cosmetics.

show abstract

Section: Introductionmentioning

confidence: 99%

New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The compound with CID ID 10621 is "hesperidin", which is a type of flavanon glycoside and generally present in citrus fruits. In general, citrus peels contain hesperidin content in a greater concentration than other parts of the fruit, and this bioflavanoid has a variety of applications [40]. Hence, based upon the results of the above docking interaction, we can speculate that intervention of a potential inhibitor (ligand) helps in the modulation of the TCA biochemical cycle, and ultimately promotes the stress condition of a higher concentration of acetyl-CoA.…”

Section: Molecular Docking Studies Of Citrate Synthasementioning

confidence: 99%

RSM–GA Based Optimization of Bacterial PHA Production and In Silico Modulation of Citrate Synthase for Enhancing PHA Production

et al. 2019

View full text Add to dashboard Cite

The inexhaustible nature and biodegradability of bioplastics like polyhydroxyalkanoates (PHAs) make them suitable assets to replace synthetic plastics. The eventual fate of these eco-friendly and non-toxic bioplastics relies upon the endeavors towards satisfying cost and, in addition, execution necessity. In this study, we utilized and statistically optimized different food (kitchen-/agro-) waste as a sole carbon/nitrogen source for the production of PHA at a reduced cost, indicating a proficient waste administration procedure. Seven different types of kitchen-/agro-waste were used as unique carbon source and four different types of nitrogen source were used to study their impact on PHA production by Bacillus subtilis MTCC 144. Among four different studied production media, mineral salt medium (MSM) (biomass: 37.7 g/L; cell dry weight: 1.8 g/L; and PHA: 1.54 g/L) was found most suitable for PHA production. Further, carbon and nitrogen components of MSM were optimized using one-factor-at-a-time experiments, and found that watermelon rind (PHA = 12.97 g/L) and pulse peel (PHA = 13.5 g/L) were the most suitable carbon and nitrogen sources, respectively, in terms of PHA (78.60%) recovery. The concentrations of these factors (sources) were statistically optimized using response surface methodology coupled with the genetic algorithm approach. Additionally, in order to enhance microbial PHA production, the interaction of citrate synthase, a key enzyme in the TCA cycle, with different known inhibitors was studied using in silico molecular docking approach. The inhibition of citrate synthase induces the blockage of the tricarboxylic cycle (TCA), thereby increasing the concentration of acetyl-CoA that helps in enhanced PHA production. Molecular docking of citrate synthase with different inhibitors of PubChem database revealed that hesperidin (PubChem compound CID ID 10621), generally present in citrus fruits, is the most efficient inhibitor of the TCA cycle with the binding score of -11.4 and warrants experimental validation. Overall, this study provides an efficient food waste management approach by reducing the production cost and enhancing the production of PHA, thereby lessening our reliance on petroleum-based plastics.

show abstract

“…Induction.Diabetes was induced by injecting a dose of 120 mg/kg of Streptozotocin intraperitonially [23][24][25][26][27][28]. The rats ware kept for 7 days with free access to food and water.…”

Section: Anti-diabetic Activitymentioning

confidence: 99%

Formulation and development of hesperidin loaded solid lipid nanoparticles for diabetes

2019

Biointerface Res Appl Chem

View full text Add to dashboard Cite

Most of the research on Diabetes has been focused on synthetic compound however the disease burden of Diabetes has not been reduced, natural chemistry has provided various safer options in different disease areas. Hesperidin (bioflavonoid) has shown good promise in anti-diabetes efficacy however its bioavailability is low. In this work, SLN of Hesperidin wasprepared, physiochemically evaluated and tested for anti-diabetic potential. Various drug- lipid ratio were tested along with other formulation parameter for fabrication of formulation and optimization. The optimized formulation has been shownuniform particle size with negative surface charge with more than 90% entrapment efficiency and 91.45% drug release. The formulation exhibited Korsmeyer-Peppas release kinetic. The optimize formulation showed 21 % increase in anti-diabetes activity of hesperidin.

show abstract

Benefits of Hesperidin for Cutaneous Functions

Cited by 106 publications

References 135 publications

New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

New Sustainable Process for Hesperidin Isolation and Anti-Ageing Effects of Hesperidin Nanocrystals

RSM–GA Based Optimization of Bacterial PHA Production and In Silico Modulation of Citrate Synthase for Enhancing PHA Production

Formulation and development of hesperidin loaded solid lipid nanoparticles for diabetes

Contact Info

Product

Resources

About