Benefits of intravenous lidocaine on post-operative pain and acute rehabilitation after laparoscopic nephrectomy

Tauzin-Fin, P.; Bernard, O.; Sesay, Musa; Biais, Matthieu; Richebé, Philippe; Quinart, Alice; Revel, Philippe; Sztark, F.

doi:10.4103/0970-9185.137269

Cited by 48 publications

(39 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Target-controlled infusion of sufentanil (Gepts pharmacokinetic model) was used during anesthesia with sevoflurane to maintain the BIS value between 40 and 50. Intraoperative sufentanil consumption was similar for both groups (139 µg vs 121 µg), and no difference in time to tracheal extubation was noted [25]. Butterworth et al suggested inhibition of brain cell excitability as a mechanism for analgesia from infused lidocaine by increasing the current threshold of rat hippocampal pyramidal cells.…”

Section: Discussionmentioning

confidence: 99%

“…In another study, in patients undergoing laparoscopic cholecystectomy, the total fentanyl consumption was found to be significantly lower in the lidocaine group (242 ± 48.5 µg vs 323 ± 70.8 µg) [32]. It should be pointed out the evidence for an opioid sparing effect of systemic lidocaine is not consistently clear in the published clinical literature regardless of whether lidocaine is used with volatile or intravenous anesthesia [11,22,23,25,30,33]. However, the evidence is strong in support of the effect of systemic lidocaine in reducing the total dose of volatile anesthetic required for general anesthesia.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

Nakhli

Kahloul

Guizani

et al. 2018

Libyan Journal of Medicine

View full text Add to dashboard Cite

The role of intraoperative intravenous lidocaine infusion has been previously evaluated for pain relief, inflammatory response, and post-operative recovery, particularly in abdominal surgery. The present study is a randomized double-blinded trial in which we evaluated whether IV lidocaine infusion reduces isoflurane requirement, intraoperative remifentanil consumption and time to post-operative recovery in non-laparoscopic renal surgery. Sixty patients scheduled to undergo elective non-laparoscopic renal surgery under general anesthesia were enrolled to receive either systemic lidocaine infusion (group L: bolus 1.5 mg/kg followed by a continuous infusion at the rate of 2 mg/kg/hr until skin closure) or normal saline (0.9% NaCl solution) (Group C). The depth of anesthesia was monitored using the Bispectral Index Scale (BIS), which is based on measurement of the patient’s cerebral electrical activity. Primary outcome of the study was End-tidal of isoflurane concentration (Et-Iso) at BIS values of 40–60. Secondary outcomes include remifentanil consumption during the operation and time to extubation. Et-Iso was significantly lower in group L than in group C (0.63% ± 0.10% vs 0.92% ± 0.11%, p < 10–3). Mean remifentanil consumption of was significantly lower in group L than in group C (0.13 ± 0.04 µg/kg/min vs 0.18 ± 0.04 µg/kg/min, p < 10–3). Thus, IV lidocaine infusion permits a reduction of 31% in isoflurane concentration requirement and 27% in the intraoperative remifentanil need. In addition, recovery from anesthesia and extubation time was shorter in group L (5.8 ± 1.8 min vs 7.9 ± 2.0 min, p < 10–3). By reducing significantly isoflurane and remifentanil requirements during renal surgery, intravenous lidocaine could provide effective strategy to limit volatile agent and intraoperative opioids consumption especially in low and middle income countries.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

Nakhli

Kahloul

Guizani

et al. 2018

Libyan Journal of Medicine

View full text Add to dashboard Cite

show abstract

“…[16][17][18] Other mechanisms of action influencing neuronal transmission include inhibition of G-protein coupled receptor and N-methyl-D-aspartate receptors. 19 Epidural lidocaine administration has been used commonly during obstetric procedures to provide spinal anesthesia by causing sensory and motor block. 16 Lidocaine in CSF was not measured in our study, but its concentration is presumed to be high because of its route of administration.…”

Section: Discussionmentioning

confidence: 99%

Drug Residues after Intravenous Anesthesia and Intrathecal Lidocaine Hydrochloride Euthanasia in Horses

Aleman

Davis

Knych

et al. 2016

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundIntrathecal lidocaine hydrochloride under general anesthesia has been used as an alternative method of euthanasia in equids. Carnivore, scavenger, and even human consumption of horse meat from carcasses have been anecdotally reported in rural areas after this method of euthanasia. The presence of drug residues in horse meat has not been investigated.Hypothesis/ObjectivesTo investigate if drug residues are found in horse tissues and determine their concentrations.AnimalsOf 11 horses requiring euthanasia for medical reasons.MethodsProspective descriptive study. Horses were anesthetized with total IV dose of xylazine (mean, 2.5 mg/kg), midazolam (0.1 mg/kg), and ketamine hydrochloride (mean, 5.8 mg/kg). An atlanto‐occipital cisterna centesis for the collection of cerebrospinal fluid (CSF) and administration of lidocaine hydrochloride (4 mg/kg) was performed. Blood samples for both serum and plasma, skeletal muscle (triceps brachii, gluteus medius), and CSF were collected for the determination of drug residues. Frozen skeletal muscle available from 5 additional horses that received standard dosages of drugs for short‐term anesthesia (xylazine 1.1 mg/kg, midazolam 0.1 mg/kg, and ketamine 2.2 mg/kg) also were analyzed.ResultsDrug residues were found in the tissues of all horses, but at extremely low concentrations.Conclusions and Clinical ImportanceEuthanasia by administration of lidocaine intrathecally to horses under IV anesthesia poses a low risk of toxicity to carnivores and scavengers that might consume muscle tissue from a carcass in which this protocol has been used.

show abstract

“…It has been demonstrated that lidocaine infusion accelerates bowel movements, reduces postoperative pain and opioid needs and length of hospital stay [2][3][4]. Anti-inflammatory, analgesic and antihyperalgesic effects have been implicated in lidocaine's clinical effects via different mechanisms including sodium channel blockade [6] and inhibition of G proteincoupled receptor [7].…”

Section: Introductionmentioning

confidence: 99%

“…In the last years, numerous studies have focused on the effects of lidocaine infusion on postoperative pain, recovery and short term outcome [1][2][3][4][5]. It has been demonstrated that lidocaine infusion accelerates bowel movements, reduces postoperative pain and opioid needs and length of hospital stay [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative and Apoptotic Effects of Lidocaine on Human Hepatocarcinoma Cells. A preliminary study

Jurj

Tomuleasa

Tat

et al. 2017

JGLD

View full text Add to dashboard Cite

Background & Aims: It is now well documented that certain anesthetic techniques may influence long term outcome in cancer patients undergoing surgery. More recently, local anesthetics proved certain antiproliferative effects in cancer cells. In our study, we aimed to investigate if lidocaine has antiproliferative effects in human hepatocarcinoma cells and to identify possible mechanisms of these effects.Methods. We investigated the inhibitory effect of different concentrations of lidocaine on the proliferation of cultured HepG2 human hepatocarcinoma cells and LX2 normal liver fibroblasts. Cells were exposed to nine different concentrations of lidocaine for 72h. MTT assay was used to investigate HepG2 and LX2 proliferation while Western blotting was used for detection of p53 expression level.Results. Our data showed that lidocaine inhibited cell proliferation in a concentration-dependent manner in both HepG2 and LX2. The antiproliferative effects of lidocaine in LX2 were significantly diminished as compared with those in HepG2 (p< 0.001). Similarly, the expression level of p53 was significant decreased in HepG2 lines treated with lidocaine as compared with control and LX2 (p = 0.0241).Conclusions. In clinically relevant concentrations, lidocaine had significant antiproliferative effects on human hepatocarcinoma cells. These effects were time and dose-dependent. One of the possible mechanisms of these effects is by modifying the P53 expression level. The relevance of these findings in clinical practice is limited; clinical impact of these effects on the outcome of patients with hepatocarcinoma undergoing surgery or minimal invasive procedures needs to be demonstrated in future animal models and clinical studies.Abbreviations: DMSO: dimethyl sulfoxide; DNA: deoxyribonucleic acid; EDTA: ethylenediaminetetraacetic acid; EGFR: epidermal growth factor receptor; MTT assay: 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide assay; NK cells: natural killer cells; RCTs: randomized controlled studies; VGSC: voltage gated sodium channels.

show abstract

Benefits of intravenous lidocaine on post-operative pain and acute rehabilitation after laparoscopic nephrectomy

Cited by 48 publications

References 33 publications

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

Drug Residues after Intravenous Anesthesia and Intrathecal Lidocaine Hydrochloride Euthanasia in Horses

Antiproliferative and Apoptotic Effects of Lidocaine on Human Hepatocarcinoma Cells. A preliminary study

Contact Info

Product

Resources

About