Benefits of p-coumaric acid in mice with rotenone-induced neurodegeneration

Dolrahman, Nurinee; Mukkhaphrom, Waritsara; Sutirek, Jeanjira; Thong-asa, Wachiryah

doi:10.1007/s11011-022-01113-2

Cited by 14 publications

(12 citation statements)

References 39 publications

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“…In rotenone-induced PD-like pathology mice, p-coumaric acid (100 mg/kg) inhibits neurodegeneration via antilipid peroxidation, as well as inhibiting anti-inflammatory-related TNF-α, and has a nurturing effect on tyrosine hydroxylase levels in the substantia nigra and striatum, leading to the alleviation of dyskinesia. 110 In conclusion, these studies suggest that ferulic acid may exert powerful anti-inflammatory effects by modulating signaling pathways such as NF-κB, MAPK, and PPARγ and inhibiting the activation of microglia and astrocytes, thus promising to be an emerging therapeutic target for PD.…”

Section: Antineuroinflammation Of Hydroxycinnamic Acid Derivativesmentioning

confidence: 82%

“…Other derivatives of hydroxycinnamic acid such as p -coumaric acid have been found to have protective effects against PD. In rotenone-induced PD-like pathology mice, p -coumaric acid (100 mg/kg) inhibits neurodegeneration via antilipid peroxidation, as well as inhibiting anti-inflammatory-related TNF-α, and has a nurturing effect on tyrosine hydroxylase levels in the substantia nigra and striatum, leading to the alleviation of dyskinesia …”

Section: Pharmacological Effects Of Hydroxycinnamic Acid Derivatives:...mentioning

confidence: 99%

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The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Yang

Nao

Dong

2023

J. Agric. Food Chem.

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Hydroxycinnamic acid derivatives (HCDs) are polyphenols that are abundant in cereals, coffee, tea, wine, fruits, vegetables, and other plant-based foods. To aid in the clinical prevention and treatment of Parkinson’s disease (PD), we evaluated in vivo investigations of the pharmacological properties of HCDs relevant to PD, and their pharmacokinetic and safety aspects. An extensive search of published journals was conducted using several literature databases, including PubMed, Google Scholar, and the Web of Science. The search terms included “hydroxycinnamic acid derivatives,” “ferulic acid,” “caffeic acid,” “sinapic acid,” “p-coumaric acid,” “Parkinson’s disease,” and combinations of these keywords. As of April 2023, 455 preclinical studies were retrieved, of which 364 were in vivo studies; we included 17 of these articles on the pharmaceutics of HCDs in PD. Available evidence supports the protective effects of HCDs in PD due to their anti-inflammatory, antioxidant, as well as antiapoptotic physiological activities. Studies have identified possible molecular targets and pathways for the protective actions of HCDs in PD. However, the paucity of studies on these compounds in PD, and the risk of toxicity induced with high-dose applications, limits their use. Thus, multifaceted studies of HCDs in vitro and in vivo are needed.

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Section: Antineuroinflammation Of Hydroxycinnamic Acid Derivativesmentioning

confidence: 82%

Section: Pharmacological Effects Of Hydroxycinnamic Acid Derivatives:...mentioning

confidence: 99%

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Yang

Nao

Dong

2023

J. Agric. Food Chem.

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“…Finally, in rats, prophylactic administration of kaempferol decreases hippocampal neurodegeneration induced by the insecticide chlorpyrifos [ 49 ]. Similarly, p-coumaric acid reduces dopaminergic neurodegeneration and mitigates motor deficits in mice exposed to the insecticide rotenone [ 50 ].…”

Section: Discussionmentioning

confidence: 99%

Oral administration of phytochemicals protects honey bees against cognitive and motor impairments induced by the insecticide fipronil

García,

Caicedo-Garzón,

Riveros

2024

PLoS ONE

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Pollution produced by exposure to pesticides is a major concern for food security because the negative impacts on pollinators. Fipronil, an insecticide broadly used around the globe has been associated with the ongoing decline of bees. With a characteristic neuroactive toxicodynamic, fipronil leads to cognitive and motor impairments at sublethal dosages. Despite of regional bans, multilevel strategies are necessary for the protection of pollinators. Recent evidence suggests that specific nutrients in the diets of bees may induce protection against insecticides. Here, we evaluated whether the administration of three phytochemicals, namely rutin, kaempferol and p-coumaric acid provide protection to the Africanized honey bee Apis mellifera against oral administration of realistic dosages of fipronil. We tested the potential impairment produced by fipronil and the protection induced by the phytochemicals in learning, 24h memory, sucrose sensitivity and motor control. We found that the administration of fipronil induced a concentration-dependent impairment in learning and motor control, but not 24h memory or sucrose sensitivity across a 24h window. We also found that the administration of rutin, p-coumaric acid, kaempferol and the mixture was innocuous and generally offered protection against the impairments induced by fipronil. Overall, our results indicate that bees can be prophylactically protected against insecticides via nutrition, providing an alternative to the ongoing conflict between the use of insecticides and the decline of pollinators. As the studied phytochemicals are broadly present in nectar and pollen, our results suggest that the nutritional composition, and not only its production, should be considered when implementing strategies of conservation via gardens and co-cropping.

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“…According to literatures, it is a phenolic compound that can be found in a wide variety of edible plants and mushrooms. In vitro and in vivo studies have demonstrated that p-CA possesses multiple bioactivities of pharmacological qualities that support its ability to have impacts on blood sugar, hyperlipidaemia, neurodegeneration, analgesia, arthritis, anxiolysis, cancer, ulcers, oxidation, anti-platelet aggregation and inflammation [36][37][38] . Coumaric acid have also been report to prevent liver damage induced by CCl 4 or BDL (necrosis and cholestasis) and exhibits amoebostatic activity against Entamoeba histolytica 39 .…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition and Antiplasmodial Potential of Fruit Extract of Hunteria umbellata on Chloroquine-Sensitive Plasmodium berghei berghei (NK65)-Infected Albino Mice

Onygeme-Okerenta,

Minadoki,

Amadi

2023

Asian J. Emerg. Res

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Background and Objective: Hunteria umbellata plant is used in African traditional medicine for treating a variety of illnesses including malaria. This study evaluated the bioactive compounds, proximate composition and the antiplasmodial potentials of the fruit extract of H. umbellata. Materials and Methods:The fruits of H. umbellata were air-dried for 21 days. The dried fruits were pulverized into a fine powder and extracted with 20 mL of dichloromethane, concentrated on a steam bath to about 5 mL and air-dried to about 2 mL for GC-MS analyses. A total of 105 albino mice were divided into 3 sets of 35 mice used for the curative, chemo-suppressive and prophylactic assessment, respectively. Each set is comprised of 7 groups of 5 mice. Groups 1-7 were infected with Plasmodium berghei. Group 1 received distilled water only, Group 2 received 5 mg kgG 1 b.wt., of chloroquine phosphate.

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Benefits of p-coumaric acid in mice with rotenone-induced neurodegeneration

Cited by 14 publications

References 39 publications

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

The Therapeutic Potential of Hydroxycinnamic Acid Derivatives in Parkinson’s Disease: Focus on In Vivo Research Advancements

Oral administration of phytochemicals protects honey bees against cognitive and motor impairments induced by the insecticide fipronil

Phytochemical Composition and Antiplasmodial Potential of Fruit Extract of Hunteria umbellata on Chloroquine-Sensitive Plasmodium berghei berghei (NK65)-Infected Albino Mice

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