Benefits of Sleep Extension on Sustained Attention and Sleep Pressure Before and During Total Sleep Deprivation and Recovery

Arnal, Pierrick J.; Sauvet, Fabien; Léger, Damien; Beers, Pascal Van; Bayon, Virginie; Bougard, Clément; Rabat, Arnaud; Millet, Guillaume Y.; Chennaoui, Mounir

doi:10.5665/sleep.5244

Cited by 123 publications

(115 citation statements)

References 44 publications

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“…In the present study, even if blood was only sampled at two time points in the day, the significant time of day effect for prolactin concentration may reflect its circadian phase. The lower prolactin concentrations seen at baseline and after night recovery in the extended sleep condition were likely the result of longer REM sleep duration, as we have shown previously (3). This effect of sleep extension can hardly be explained by a circadian phase shift because sleep durations were the same in recovery night in both conditions.…”

Section: Discussionmentioning

confidence: 47%

“…Indeed, cognitive performance deficits induced by sleep deprivation were typically found to be most severe in the early morning (approximately 06.00-08.00 h) compared to later in the day (approximately 16.00-20.00 h) when the effects of sleep deprivation are offset by the ascending phase of the circadian rhythm (3,54).…”

Section: Discussionmentioning

confidence: 99%

“…caffeine) (25). Sleep extension helped maintain cognitive performance and alertness during sleep loss, as did a short nap or small repetitive doses of caffeine (3,26,27). A 5-7-week sleep extension period (minimum goal of 10 h in bed each night) improved athletic performance, reaction time, daytime sleepiness and mood (28).…”

mentioning

confidence: 97%

“…Key words: sleep extension, sleep deprivation, hormones, healthy men doi: 10.1111/jne.12346 Accumulating evidence from both observational and experimental research suggests that a short sleep duration may impair cognitive function (1)(2)(3), as well as endocrine and metabolism regulation (4), and thus might represent a challenge to human health. Acute total sleep deprivation (TSD) in humans is associated with changes in the hypothalamic-pituitary-adrenal and hypothalamic-pituitary-gonadal axes (5)(6)(7)(8)(9).…”

mentioning

confidence: 99%

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Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery

Arnal

Drogou

Sauvet

et al. 2016

J Neuroendocrinology

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Total sleep deprivation (TSD) in humans is associated with altered hormonal levels, which may have clinical relevance. Less is known about the effect of an extended sleep period before TSD on these hormonal changes. Fourteen subjects participated in two experimental counterbalanced conditions (randomised cross-over design): extended sleep (21.00-07.00 h time in bed, EXT) and habitual sleep (22.30-07.00 h time in bed, HAB). For each condition, subjects performed two consecutive phases: six nights of either EXT or HAB. These nights were followed by 3 days in the sleep laboratory with blood sampling at 07.00 and 17.00 h at baseline (B-07.00 and B-17.00), after 24 and 34 h of continuous awakening (24 h-CA, 34 h-CA) and after one night of recovery sleep (R-07.00 and R-17.00) to assess testosterone, cortisol, prolactin and catecholamines concentrations. At 24 h of awakening, testosterone, cortisol and prolactin concentrations were significantly lower compared to B-07.00 and recovered basal levels after recovery sleep at R-07.00 (P < 0.001 for all). However, no change was observed at 34 h of awakening compared to B-17.00. No effect of sleep extension was observed on testosterone, cortisol and catecholamines concentrations at 24 and 34 h of awakening. However, prolactin concentration was significantly lower in EXT at B-07.00 and R-07.00 compared to HAB (P < 0.05, P < 0.001, respectively). In conclusion, 24 h of awakening inhibited gonadal and adrenal responses in healthy young subjects and this was not observed at 34 h of awakening. Six nights of sleep extension is not sufficient to limit decreased concentrations of testosterone and cortisol at 24 h of awakening but may have an impact on prolactin concentration.

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Section: Discussionmentioning

confidence: 47%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

mentioning

confidence: 99%

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Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery

Arnal

Drogou

Sauvet

et al. 2016

J Neuroendocrinology

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“…The primary objective was to demonstrate the superiority of THN102 vs MOD100 at the nadir time point (at 06:00 on Day 1, 5 hours after dose 1). The 06:00 hour corresponds to the highest decrease of attentional performance, observed after 23 hours of sleep deprivation, due to continuous awakening (sleep pressure) and the nadir of circadian rhythm . With 20 evaluable subjects and at least 57 evaluable periods (i.e.…”

Section: Methodsmentioning

confidence: 99%

Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40‐hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target

Sauvet

Erblang

Gomez-Mérino

et al. 2019

Brit J Clinical Pharma

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Aims THN102 is a novel combination of modafinil and low‐dose flecainide, targeting glial connexin activity to modulate modafinil effects. We investigated THN102 efficacy compared to modafinil and to placebo on vigilance and cognitive function during 40‐hour total sleep deprivation (TSD). Methods Twenty healthy men participated in a double‐blind, randomized, incomplete‐block 3‐period cross‐over trial with 5 treatments (n = 12 per group): placebo (PBO), modafinil 100 mg (MOD100), THN102 100/1, 100/3, 100/9 (modafinil 100 mg and flecainide 1, 3 or 9 mg). Each period included a baseline day and a TSD day with treatments administered 3 times (01:00, 09:00 and 19:00). Reaction time in psychomotor vigilance test, subjective somnolence and vital signs were assessed before and during treatment. Working memory (2‐Back) and executive processes (Go/noGo for vigilance and inhibition, Wisconsin card sorting task for mental flexibility, and Tower of London test for planning) were evaluated at 16:30. Results At 5 hours postdose−1 (after 23 hours TSD, primary endpoint), THN102 100/1 resulted in statistically higher psychomotor vigilance test speed vs MOD100 (3.97 ± 0.09 vs 3.74 ± 0.14, P < .05). No increase in effect was observed with higher flecainide doses in combinations. Most THN102 doses vs MOD100 also improved the number of correct responses in 2‐Back and Go errors in Go/noGo (P < .05 for all doses), and perseverative responses in Wisconsin card sorting task (for 100/1 and 100/9). No impact on cardiac conduction was noted with THN102, and safety was similar to MOD100. Conclusions THN102 seems more efficient than modafinil on vigilance, working memory and executive functions, opening new perspectives in management of hypersomnolence disorders.

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Sleep deprivation and recovery: Endurance racing as a novel model

Mann,

Pattinson,

Allan

et al. 2024

European Journal of Sport Science

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The aim of this study was to investigate sleep‐wake behavior and gain insights into perceived impairment (sleep, fatigue, and cognitive function) of athletes competing in two international multi‐day adventure races. Twenty‐four athletes took part across two independent adventure races: Queensland, Australia and Alaska, USA. Individual sleep periods were determined via actigraphy, and racers self‐reported their perceived sleep disturbances, sleep impairment, fatigue and cognitive function. Each of these indices was calculated for pre‐, during‐ and post‐race periods. Sleep was severely restricted during the race period compared to pre‐race (Queensland, 7:46 [0:29] vs. 2:50 [1:01]; Alaska, 7:39 [0:58] vs. 2:45 [2:05]; mean [SD], hh:mm). As a result, there was a large cumulative sleep debt at race completion, which was not ‘reversed’ in the post‐race period (up to 1 week). The deterioration in all four self‐reported scales of perceived impairment during the race period was largely restored in the post‐race period. This is the first study to document objective sleep‐wake behaviors and subjective impairment of adventure racers, in the context of two geographically diverse, multi‐day, international adventure races. Measures of sleep deprivation indicate that sleep debt was extreme and did not recover to pre‐race levels within 1 week following each race. Despite this objective debt continuing, perceived impairment returned to pre‐race levels quickly post‐race. Therefore, further examination of actual and perceived sleep recovery is warranted. Adventure racing presents a unique scenario to examine sleep, performance and recovery.

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Benefits of Sleep Extension on Sustained Attention and Sleep Pressure Before and During Total Sleep Deprivation and Recovery

Abstract: Six nights of extended sleep improve sustained attention and reduce sleep pressure. Sleep extension also protects against psychomotor vigilance task lapses and microsleep degradation during total sleep deprivation. These beneficial effects persist after one night of recovery sleep.

Cited by 123 publications

References 44 publications

Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery

Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery

Efficacy of THN102 (a combination of modafinil and flecainide) on vigilance and cognition during 40‐hour total sleep deprivation in healthy subjects: Glial connexins as a therapeutic target

Sleep deprivation and recovery: Endurance racing as a novel model

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