Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy

Nahás, Eliana Aguiar Petri; Neto, Jorge Nahás; Luca, Laurival de; Traiman, Paulo; Pontes, Anaglória; Dalben, Ivete

doi:10.1016/j.maturitas.2003.09.026

Cited by 71 publications

(27 citation statements)

References 39 publications

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“…To sample size estimation, we used similar study [22], hot flashes as a primary outcome were significantly reduced in the isoflavones group (score from 7.0 ± 1.8 to 3.4 ± 3.2) compared with in the placebo group (score from 6.4 ± 2.4 to 5.2 ± 2.7). We estimated that a sample of 43 postmenopausal women for each group would be required to detect a difference with a power 80% and a two-sided α level of 5%.…”

Section: Methodsmentioning

confidence: 99%

Effect of soy isoflavones supplement on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women: a randomized clinical trial

2017

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BACKGROUND/OBJECTIVESSoy isoflavones are expected to improve menopausal symptoms and osteoporosis in women. However, their efficacy is still inconclusive, and there was limited data for postmenopausal women in South Korea. We examined the effects of soy isoflavones on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women.SUBJECTS/METHODSA randomized, double-blind study design was used. Eighty-seven participants who had undergone natural menopause were randomly administered either 70 mg/day isoflavones (n = 43) or placebo (n = 41) for 12 weeks. We assessed the Kupperman index for climacteric symptoms and the menopause-specific quality of life (MENQOL) questionnaire for quality of the life. Biomarkers of bone metabolism were also measured in serum bone-specific alkaline phosphatase (BALP), osteocalcin (OC), N- and C-terminal cross-linking telopeptides of type I collagen (NTx, CTx), and urine-deoxypyridinolin (u-DPD).RESULTSScores of the Kupperman index were decreased in both the isoflavones group (−7.0 ± 15.8, P = 0.0074) and placebo group (−6.3 ± 14.6, P = 0.0064) during the intervention, but no significant difference was noted between the groups. Regarding the bone formation markers, the level of serum BALP increased by 6.3 ± 4.1% (P = 0.004) and OC increased by 9.3 ± 6.2% (P < 0.001), meanwhile those of the placebo were not changed. For the bone resorption markers, NTx, CTx, and u-DPD were not significantly different in either group. MENQOL was significant decreased in the isoflavone group (−0.6 ± 0.5) and placebo group (−0.6 ± 0.4), with a significant difference between groups (P = 0.0228).CONCLUSIONSOur study suggests that 70 mg isoflavones supplement has beneficial effects on bone formation markers; however, it showed no benefit compared to the placebo on climacteric symptoms or quality of life.

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Section: Methodsmentioning

confidence: 99%

Effect of soy isoflavones supplement on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women: a randomized clinical trial

2017

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“…After excluding two RCTs (Tormala et al 2006; Badeau et al 2007) that were subset analyses of an original trial (Nikander et al 2004) and two (Lissin et al 2004; Petri Nahas et al 2004) in which actual endpoint TC and LDL-C values were not clear, 12 RCTs (Nestel et al 1997; Simons et al 2000; Dewell et al 2002; Uesugi et al 2002, 2003, 2004; Nikander et al 2004; Yildiz et al 2005; Garrido et al 2006; Hall et al 2006; Cheng et al 2007; Gonzalez et al 2007) and 10 RCTs (Nestel et al 1997; Simons et al 2000; Uesugi et al 2002, 2004; Nikander et al 2004; Yildiz et al 2005; Garrido et al 2006; Hall et al 2006; Cheng et al 2007; Gonzalez et al 2007) that had respectively evaluated the effects of ingesting extracted soy isoflavones alone on TC and LDL-C in adult humans for 1–3 months, and had reported actual endpoint values for each of the comparison groups, were included in the meta-analysis. Two trials (Yildiz et al 2005; Garrido et al 2006) and one trial (Garrido et al 2006) were subsequently withdrawn, leaving 10 and 9 RCTs with usable information that were finally selected for meta-analysis of TC and LDL-C, respectively (see Figure 1).…”

Section: Methodsmentioning

confidence: 99%

Effects of extracted soy isoflavones alone on blood total and LDL cholesterol: Meta-analysis of randomized controlled trials

Taku¹,

Umegaki²,

Ishimi³

et al. 2008

TCRM

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When provided concurrently with soy protein for 1–3 months, soy isoflavones exert synergistic or additive cholesterol-lowering effects. This meta-analysis was performed to evaluate the effects of extracted soy isoflavones alone (not ingested concurrently with soy protein) on total and low density lipoprotein (LDL) cholesterol. MEDLINE (1966–2007), EMBASE (1966–2007), CENTRAL (1966–2007), ICHUSHI (1983–2008), and CNKI (1979–2007) were searched for randomized placebo-controlled trials published in English, Japanese, and Chinese, describing the changes in lipid profiles in adult humans resulting from ingestion of extracted soy isoflavones for 1–3 months. Reference lists of relevant systematic reviews and meta-analyses were hand-searched. Meta-analysis of 10 and 9 trials with usable information using REVMAN found that an average of 70 mg soy isoflavones/day (27–132 mg, as the aglycone form) alone had a nonsignificant effect on total (0.01 mmol/L [95% CI: –0.12, 0.14]; P = 0.86) and LDL (0.03 mmol/L [95% CI: –0.11, 0.16]; P = 0.71) cholesterol in menopausal women, respectively. It is concluded that ingestion of about 70 mg extracted soy isoflavones/day alone for 1–3 months does not improve total and LDL cholesterol levels in normocholesterolemic menopausal women; further studies are needed to verify the effects of extracted soy isoflavones.

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“…The whole soybean seed contains only 2% soy germ, and the highest quantity of isoflavones is found in the soy germ. Isoflavones found in soy germ are 5-6 times higher than the other parts, for instance, seed coat and cotyledon (Nahas et al, 2004). There is an investigation of isoflavone and antioxidant activity in cotyledon, seed coat and soy germ from four varieties of soybean.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Isoflavone glucosides from Soy germ and β-Glucosidase from Bacillus coagulans PR03 for Isoflavone aglycones Production

Chaipoot¹,

Phongphisutthinant²,

Sriwattana³

et al. 2019

CMUJNS

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This research optimized isoflavone aglycones production from soy germ. The processes included isoflavone glucosides extraction from soy germ to use as a precursor for isoflavone aglycones production. β-glucosidase was produced from B. coagulans PR03 and used to convert glucosides form to aglycones. For the β-glucosidase production using Plackett and Burman Design (n=8) and 2 2 factorial experiment with central composite design, the suitable medium containing peptone (2.00%), beef extract (14.84%), glucose (2.00%) and magnesium sulphate (0.10%) with pH 7.96 was used and incubated at 30 o C. The resulting β-glucosidase activity was 4.01 mU/ml. However, the isoflavone glucosides was extracted by use of soy germ in 80% ethanol at a ratio of 1:5 with high power ultrasonication technique at 80 o C for 160 min using a completely randomized design. The extracted isoflavone glucosides contained daidzin, genistin and glycitin of 307.47, 214.84 and 73.63 mg/100 g. (dry basis), respectively. Finally, isoflavone aglycones production

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Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy

Cited by 71 publications

References 39 publications

Effect of soy isoflavones supplement on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women: a randomized clinical trial

Effect of soy isoflavones supplement on climacteric symptoms, bone biomarkers, and quality of life in Korean postmenopausal women: a randomized clinical trial

Effects of extracted soy isoflavones alone on blood total and LDL cholesterol: Meta-analysis of randomized controlled trials

Preparation of Isoflavone glucosides from Soy germ and β-Glucosidase from Bacillus coagulans PR03 for Isoflavone aglycones Production

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