Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

Jia, Wen; Lei, Xiaoping; Dong, Wei; Li, Qingping

doi:10.1186/s12887-018-1013-2

Cited by 29 publications

(18 citation statements)

References 29 publications

(26 reference statements)

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“…NSE is a glycolytic enzyme, which can be detected in high concentrations in the neuron cell cytoplasm and is released into the extracellular space in cell death [9]. It is an early biochemical predictor of brain damage in newborns and can also help us understand the extent of neuronal damage and assess its prognosis [11]. The S100B protein is highly specific for the nervous system, and is secreted in large amounts from astrocytes into the blood and cerebrospinal fluid (CSF) in neuronal tissue damage [9].…”

Section: Discussionmentioning

confidence: 99%

The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia

et al. 2021

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The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia ABSTRACT Background/aim: Postnatal corticosteroids are commonly used to treat bronchopulmonary dysplasia (BPD). We aimed to show whether S100 calcium-binding B (S100B), neuron-specific enolase (NSE), Tau protein or microtubule-associated protein tau (MAPT), and glial fibrillary acid protein (GFAP) levels would provide any evidence of early neurological damage in premature infants receiving postnatal low dose dexamethasone therapy for BPD treatment. Materials and methods:In this cohort study, 136 preterm infants diagnosed with BPD at ≤32 weeks of gestation formed the study group and 64 preterm infants formed the control group. NSE, S100B, GFAP, and MAPT levels were first measured before the postnatal corticosteroid treatment in both the patient and the control group on the 28th day and, for a second time, after treatment termination in the patient group.Results: There were significant differences between the measured GFAP, MAPT, and NSE values of the BPD and control groups on the 28th day, whereas there was no significant difference between the measured S100B values of the two groups. There were a statistically significant difference between the NSE values measured on the 28th day and after the treatment within the BPD group, whereas no significant difference existed between the GFAP, MAPT, and S100B values. Conclusion:NSE levels, which indicate brain damage in the early period, increased in preterm babies with BPD who had been administered postnatal dexamethasone.

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Section: Discussionmentioning

confidence: 99%

The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia

et al. 2021

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“…The criteria for whole‐body hypothermia were (1) an Apgar score ≤3 at 1 min or ≤5 at 5 min or continued need for resuscitation, (2) an umbilical cord blood or arterial blood pH < 7.0 within 1 h after birth or a base deficit >16 mmol/L, and (3) assessed with moderate/severe HIE or abnormal aEEG. Whole‐body hypothermia was initiated within 12 h of age using a cooling mattress. A rectal temperature of 33°C–34°C was achieved within 60 min and maintained for 72 h, followed by rewarming at 0.5°C per hour until a rectal temperature of 36.5°C for more than 6 h. All eligible infants underwent aEEG and were tracked until 12 months for neurodevelopmental outcomes.…”

Section: Methodsmentioning

confidence: 99%

Prognostic value of amplitude‐integrated EEG in neonates with high risk of neurological sequelae

Xiao

Kang

Shi

et al. 2020

Ann Clin Transl Neurol

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Objective To determine the efficacy and the prognostic value of amplitude‐integrated electroencephalography (aEEG) in term and near‐term neonates with high risk of neurological sequelae. Methods Infants of ≥35 weeks of gestation diagnosed with neonatal encephalopathy or with high risk of brain injury were included. All eligible infants underwent aEEG within 6 h after clinical assessment. The infants were followed up 12 months to evaluate neurological development. Results A total of 250 infants were eligible, of which 85 had normal aEEG, 81 had mildly abnormal aEEG, and 84 had severely abnormal aEEG. Of these infants, 168 were diagnosed with different neonatal encephalopathies, 27 with congenital or metabolic diseases, and 55 with high risk of brain injury. In all, 22 infants died, 19 were lost to follow‐up, and 209 completed the follow‐up at 12 months, of which 62 were diagnosed with a neurological disability. Statistical analysis showed that severely abnormal aEEG predicted adverse neurological outcome with a sensitivity of 70.2%, a specificity of 87.1%, a positive predictive value of 75.6%, and a negative predictive value of 83.7%. Interpretation aEEG can predict adverse outcomes in high‐risk neonates and is a useful method for monitoring neonates with high risk of adverse neurological outcomes.

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“…The distinct therapeutic hypothermia methods including the start time of the hypothermia therapy and treatment modality. It was observed in [107], newborns with moderate HIE, starting hypothermia therapy within 6 h and between 6 to 12 h after HIE showed curative effects. While for the newborns with severe HIE, only starting hypothermia therapy within 6 h showed curative effects.…”

Section: Discussionmentioning

confidence: 95%

Amplitude-Integrated Electroencephalography Applications and Algorithms in Neonates: A Systematic Review

et al. 2019

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Amplitude-integrated electroencephalography (aEEG) is a simplified method for long-term, continuous, and bedside monitoring of brain activity. While conventional Electroencephalography (EEG) is the gold standard of assessing brain function, aEEG is easy to operate and allows bedside interpretation of brain activity by health care providers without extensive knowledge of neurophysiology. aEEG is increasingly applied in neurological monitoring in neonates, especially in the neonatal intensive care unit (NICU). To a growing extent, researchers and clinicians are convinced that aEEG provides valuable clinical information and can be used to assess the severity of neonatal encephalopathy. Meanwhile, to digitalize the aEEG transformation process and automate the interpretation process, different algorithms have been proposed in the last decades. This paper provides a comprehensive review of aEEG for neonatal monitoring from both clinical and technological perspectives. The paper first reviews the clinical applications of aEEG and discusses the merits and demerits of neonatal aEEG monitoring in terms of the assistance of the treatment and prognosis of cerebral diseases like hypoxic-ischemic encephalopathy (HIE), seizure and so on. And then furthermore, the algorithms to transform EEG into aEEG and the algorithms for aEEG interpretation like the automatic classification of aEEG tracing, automatic seizure detection of aEEG, etc. are reviewed.INDEX TERMS Amplitude-integrated electroencephalography, cerebral function monitoring, automatic seizure detection.

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Benefits of starting hypothermia treatment within 6 h vs. 6–12 h in newborns with moderate neonatal hypoxic-ischemic encephalopathy

Cited by 29 publications

References 29 publications

The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia

The contribution of postnatal steroid administration to early brain damage in preterm babies with bronchopulmonary dysplasia

Prognostic value of amplitude‐integrated EEG in neonates with high risk of neurological sequelae

Amplitude-Integrated Electroencephalography Applications and Algorithms in Neonates: A Systematic Review

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