Benefits of supplemental oxygen on exercise capacity in IPF patients with exercise-induced hypoxemia

Taniguchi, Hiroyuki; Sakamoto, Koji; Kondoh, Yasuhiro; Kimura, Tomoki; Kataoka, Kensuke; Ogawa, Tomoya; Watanabe, Fumio; Hirasawa, Jun; Kozu, Ryo

doi:10.1183/13993003.congress-2015.oa4971

Cited by 4 publications

(4 citation statements)

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“…We found oxygen improved exercise performance, strengthening previous findings [15][16][17][18] and we provided the first evidence that oxygen effectively reduces exertional dyspnoea in IPF.…”

Section: Discussionsupporting

confidence: 89%

“…However randomised trials comparing oxygen to air indicated that oxygen improved endurance time, VO 2 peak, minute ventilation and lactate levels. [15][16][17][18] In contrast, one study reported oxygen provided no additional benefit compared to air during the 6-minute walk test (6MWT). 19 Additionally recent evidence suggests that oxygen may even cause hyperoxia-induced oxidative stress; [20][21][22][23] thereby potentially contributing to disease progression.…”

Section: Introductionmentioning

confidence: 99%

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Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia

et al. 2017

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia

et al. 2017

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“…There was no change in dyspnea, measured with the Borg dyspnea score ( 89 ). One study reported an acute improvement in endurance time by 118.7 seconds (95% CI, 23.9–213.5 s) ( 91 ) with ambulatory oxygen compared with room air. Two other systematic reviews assessing the ambulatory oxygen in ILD were subsequently published ( 92 , 93 ) but did not meet our inclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

Home Oxygen Therapy for Adults with Chronic Lung Disease. An Official American Thoracic Society Clinical Practice Guideline

Jacobs

Krishnan

Lederer

et al. 2020

Am J Respir Crit Care Med

176

139

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Background: Evidence-based guidelines are needed for effective delivery of home oxygen therapy to appropriate patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Methods: The multidisciplinary panel created six research questions using a modified Delphi approach. A systematic review of the literature was completed, and the Grading of Recommendations Assessment, Development and Evaluation approach was used to formulate clinical recommendations. Recommendations: The panel found varying quality and availability of evidence and made the following judgments: 1 ) strong recommendations for long-term oxygen use in patients with COPD (moderate-quality evidence) or ILD (low-quality evidence) with severe chronic resting hypoxemia, 2 ) a conditional recommendation against long-term oxygen use in patients with COPD with moderate chronic resting hypoxemia, 3 ) conditional recommendations for ambulatory oxygen use in patients with COPD (moderate-quality evidence) or ILD (low-quality evidence) with severe exertional hypoxemia, 4 ) a conditional recommendation for ambulatory liquid-oxygen use in patients who are mobile outside the home and require >3 L/min of continuous-flow oxygen during exertion (very-low-quality evidence), and 5 ) a recommendation that patients and their caregivers receive education on oxygen equipment and safety (best-practice statement). Conclusions: These guidelines provide the basis for evidence-based use of home oxygen therapy in adults with COPD or ILD but also highlight the need for additional research to guide clinical practice.

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“…Cochrane review of three crossover randomized controlled trials (RCT), performed in physiology laboratories, on 98 IPF patients altogether, failed to show any effect of short-term supplementary oxygen on exertional dyspnea ( 26 ). One of the studies showed increase in endurance time during constant load ergometry ( 27 ). None of them titrated oxygen to prevent desaturation, but used pre-determined fixed oxygen flow rate.…”

Section: Breathlessness—pathophysiology and Treatmentmentioning

confidence: 99%

IPF Respiratory Symptoms Management — Current Evidence

2022

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Idiopathic pulmonary fibrosis (IPF) is a progressive, chronic disease of the lungs which is characterized by heavy symptom burden, especially in the last year of life. Despite recently established anti-fibrotic treatment IPF prognosis is one of the worst among interstitial lung diseases. In this review available evidence regarding pharmacological and non-pharmacological management of the main IPF symptoms, dyspnea and cough, is presented.

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Benefits of supplemental oxygen on exercise capacity in IPF patients with exercise-induced hypoxemia

Cited by 4 publications

References 0 publications

Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia

Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia

Home Oxygen Therapy for Adults with Chronic Lung Disease. An Official American Thoracic Society Clinical Practice Guideline

IPF Respiratory Symptoms Management — Current Evidence

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