Benefits of supportive strategies for carers of people with high-grade glioma: a systematic review

Jones, Diana; Pinkham, Mark B; Wallen, Matthew P.; Hart, Nicholas; Joseph, Ria; Strodl, Esben; Ownsworth, Tamara; Beesley, Vanessa L.; Crichton, Megan; Chan, Raymond Javan

doi:10.1007/s00520-022-07419-2

Cited by 5 publications

(2 citation statements)

References 57 publications

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“…There are potentially other factors, beyond the evaluated changes in treatment patterns, that may be associated with the improved outcomes observed over the study period. It is important to note the increasing recognition of the role of palliative care and supportive care services in the management GBM, 29,30 which is now incorporated in the Optimal Care Pathway for GBM, 31 and there is evidence that early integration of palliative care may be associated with improved survival in patients with advanced cancers 32 …”

Section: Discussionmentioning

confidence: 99%

“…15,28 There are potentially other factors, beyond the evaluated changes in treatment patterns, that may be associated with the improved outcomes observed over the study period. It is important to note the increasing recognition of the role of palliative care and supportive care services in the management GBM, 29,30 which is now incorporated in the Optimal Care Pathway for GBM, 31 and there is evidence that early integration of palliative care may be associated with improved survival in patients with advanced cancers. 32 One of the strengths of the study was that the OS outcomes in our study were obtained through routine data linkage with the Victorian Cancer Registry (VCR) at regular interval, which allowed us to accurately capture OS data, even when patients were no longer followed in our department post-treatment.…”

Section: -Year Experience Of Gbm Managementmentioning

confidence: 99%

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Management and outcomes of glioblastoma: 20‐year experience in a single Australian institution

Lenffer,

Ruben,

Senthi

et al. 2023

J Med Imag Rad Onc

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IntroductionWe aimed to evaluate the changing patterns in the management of glioblastoma (GBM) and impact on survival outcomes over a 20‐year period.MethodsThis is a retrospective study of patients diagnosed with GBM between 2001 and 2020, who had radiation therapy (RT) in an Australian institution. The primary outcomes were changes in treatment modalities (including surgery, RT, and chemotherapy) over time and overall survival (OS). Multivariable Cox regressions were used to evaluate factors associated with OS, including age, sex, ECOG performance status, treatment modalities, treatment facility, and year of treatment.Results1079 patients were included in this study. Thirty‐five per cent of patients had gross total resection, increasing from 31% in 2001–2005 to 45% in 2016–2020 (P < 0.001). Sixty‐four per cent of patients had ≥60 Gy RT, increasing from 57% in 2001–2005 to 66% in 2016–2020 (P < 0.001). Seventy‐five per cent of patients had chemotherapy, increasing from 22% in 2001–2005 to 89% in 2016–2020 (P < 0.001). Treatment received varied based on patients' age and ECOG performance status. The median OS for the entire cohort was 13.0 months (95% CI = 12.0–13.7). Median OS in patients who had maximal treatment (i.e., gross total resection, ≥60 Gy RT and chemotherapy) was 20.6 months (95% CI = 17.3–22.8). In multivariable analyses, age, sex, treatment facility, extent of surgical resection, RT dose, and chemotherapy use were associated with OS.ConclusionThis is one of the largest Australian series on the management and outcomes of GBM spanning a 20‐year period. We observed improvement in OS over time, which is likely associated with evolving treatment options over the study period.

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Section: Discussionmentioning

confidence: 99%

Section: -Year Experience Of Gbm Managementmentioning

confidence: 99%

Management and outcomes of glioblastoma: 20‐year experience in a single Australian institution

Lenffer,

Ruben,

Senthi

et al. 2023

J Med Imag Rad Onc

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The impact of a primary brain tumor diagnosis on caregivers: Insights from the patients’ perspective

Willis,

Reid,

Fox

et al. 2024

Support Care Cancer

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Purpose The diagnosis of a primary brain tumor (PBT) causes significant distress for the caregiver-patient dyad, warranting increased supportive care intervention. Although researchers have previously assessed caregivers’ perceptions of their own supportive care needs, no study to date has identified how patients perceive the caregiving experience and/or patients’ recommendations for integrating supportive care of caregivers in neuro-oncology. This qualitative study examined caregiver distress as well as caregiver supportive care needs from the patients’ perspective to inform future intervention development. Methods Adults with PBT (N = 15; Mage = 45; 53% female; 93% White) were divided into four, 90-min focus groups moderated by a clinical neuropsychologist. Patients responded to semi-structured interview questions regarding various supportive care needs throughout the course of disease. Each discussion was transcribed and coded using thematic content analysis and NVivo software. Inter-rater reliability was excellent (MKappa = 0.92, range = 0.85–0.93). Results Seven distinct codes related to PBT caregivers emerged and were classified into two broader themes: Caregiver Impact (47% of coded content) and Caregiver Support (53% of coded content). Caregiver Impact refers to patients’ perspective of the practical and emotional demands of caregiving. Under Caregiver Support, patients cited a strong need for increased support of caregivers, including bereavement care, individual psychotherapy, and joint caregiver-patient dyad sessions. Conclusion Patients with PBT expressed profound concerns regarding the demands of caregiving and its impact on the well-being of their loved ones. Findings emphasize the need for comprehensive dyadic support in neuro-oncology throughout the disease trajectory to enhance the overall quality-of-life for both patients and their caregivers.

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The experience of caregivers of patients in neuro-oncology

Applebaum,

Willis,

Sherwood

2024

Neuropsychological and Psychosocial Foundations of Neuro-Oncology

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Benefits of supportive strategies for carers of people with high-grade glioma: a systematic review

Cited by 5 publications

References 57 publications

Management and outcomes of glioblastoma: 20‐year experience in a single Australian institution

Management and outcomes of glioblastoma: 20‐year experience in a single Australian institution

The impact of a primary brain tumor diagnosis on caregivers: Insights from the patients’ perspective

The experience of caregivers of patients in neuro-oncology

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