Benefits of the povidone–iodine: Simultaneously decrease risk of infection and tumor seeding after percutaneous endoscopic gastrostomy

Chang, Wei‐Kuo; Lin, Hsuan-Hwai; Hsieh, Tsai‐Yuan; Ou, Tzu-Ming; Chen, Hsuan-Wei

doi:10.1016/j.mehy.2014.03.002

Cited by 2 publications

(4 citation statements)

References 20 publications

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“…Cancer metastasis at the PEG tube exit site in head and neck cancer patients is a rare but important problem. Possible mechanisms of this phenomenon include tumor seeding 4 , 6 , 8 and hematogenous or lymphatic spread of tumor cells. 6 , 29 – 31 The PEG tube is pulled from the upper alimentary tract to the abdominal wall, which may lead to direct contact with tumors located in the oral cavity, oropharynx, or hypopharynx.…”

Section: Discussionmentioning

confidence: 99%

“… 6 , 29 – 31 The PEG tube is pulled from the upper alimentary tract to the abdominal wall, which may lead to direct contact with tumors located in the oral cavity, oropharynx, or hypopharynx. 8 Accordingly, we hypothesized that the incidence of esophageal metastasis increases with PEG insertion by similar mechanisms. Placing a PEG using so-called pull methods is widely used in Taiwan, as compared with other techniques.…”

Section: Discussionmentioning

confidence: 99%

“… 21 , 22 Therefore, prevention of esophageal metastasis is important. Chang et al 8 hypothesized that pretreatment of PEG tubes using povidone-iodine could diminish the possibility of tumor seeding to the stoma area. Our results showed that hypopharyngeal, oropharyngeal, and laryngeal cancer patients treated with PEG had a higher incidence of subsequent esophageal cancer compared with in the control cohort (Table 2 ).…”

Section: Discussionmentioning

confidence: 99%

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Risk of Esophageal Cancer Following Percutaneous Endoscopic Gastrostomy in Head and Neck Cancer Patients

Lin

Lin²,

Lee

et al. 2016

Medicine

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Esophageal cancers account for majority of synchronous or metachronous head and neck cancers. This study examined the risk of esophageal cancer following percutaneous endoscopic gastrostomy (PEG) in head and neck cancer patients using the Taiwan National Health Insurance Research Database.From 1997 to 2010, we identified and analyzed 1851 PEG patients and 3702 sex-, age-, and index date-matched controls.After adjusting for esophagitis, esophagus stricture, esophageal reflux, and primary sites, the PEG cohort had a higher adjusted hazard ratio (2.31, 95% confidence interval [CI] = 1.09–4.09) of developing esophageal cancer than the controls. Primary tumors in the oropharynx, hypopharynx, and larynx were associated with higher incidence of esophageal cancer. The adjusted hazard ratios were 1.49 (95% CI = 1.01–1.88), 3.99 (95% CI = 2.76–4.98), and 1.98 (95% CI = 1.11–2.76), respectively.Head and neck cancer patients treated with PEG were associated with a higher risk of developing esophageal cancer, which could be fixed by surgically placed tubes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Risk of Esophageal Cancer Following Percutaneous Endoscopic Gastrostomy in Head and Neck Cancer Patients

Lin

Lin²,

Lee

et al. 2016

Medicine

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“…Similarly, free iodine is an effective tumoricidal agent and is becoming increasingly popular as an antitumour treatment in clinical practice. PVP-I has been widely used as an irrigation fluid during percutaneous endoscopic gastrostomy and in head, neck, and colorectal cancer surgery to eliminate free cancer cells to prevent implantation, metastasis and recurrence ( Wu et al, 1998 ; Basha et al, 2000 ; Pattana-arun and Wolff, 2008 ; Hah et al, 2012 ; Chang et al, 2014 ). Furthermore, in a rat model study, researchers found that tumour formation can be impeded by the presence of iodine.…”

Section: Introductionmentioning

confidence: 99%

Self-Assembling Imageable Silk Hydrogels for the Focal Treatment of Osteosarcoma

Peng

Wang³

et al. 2022

Front. Cell Dev. Biol.

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Background: The standard treatment for osteosarcoma comprises complete surgical resection and neoadjuvant chemotherapy, which may cause serious side effects and partial or total limb loss. Therefore, to avoid the disadvantages of traditional treatment, we developed self-assembling imageable silk hydrogels for osteosarcoma.Methods: We analysed whether iodine induced apoptosis in MG-63 and Saos-2 cells by using CCK-8 and flow cytometry assays and transmission electron microscopy. Western blotting was used to analyse the pathway of iodine-induced apoptosis in osteosarcoma cells. PEG400, silk fibroin solution, polyvinylpyrrolidone iodine (PVP-I), and meglumine diatrizoate (MD) were mixed to produce an imageable hydrogel. A nude mouse model of osteosarcoma was established, and the hydrogel was injected locally into the interior of the osteosarcoma with X-ray guidance. The therapeutic effect and biosafety of the hydrogel were evaluated.Results: Iodine treatment at 18 and 20 µM for 12 h resulted in cell survival rate reduced to 50 ± 2.1% and 50.5 ± 2.7% for MG-63 and Sao-2 cells, respectively (p < 0.01). The proportion of apoptotic cells was significantly higher in the iodine-treatment group than in the control group (p < 0.05), and apoptotic bodies were observed by transmission electron microscopy. Iodine could regulate the death receptor pathway and induce MG-63 and Saos-2 cell apoptosis. The hydrogels were simple to assemble, and gels could be formed within 38 min. A force of less than 50 N was required to inject the gels with a syringe. The hydrogels were readily loaded and led to sustained iodine release over 1 week. The osteosarcoma volume in the PEG-iodine-silk/MD hydrogel group was significantly smaller than that in the other three groups (p < 0.001). Caspase-3 and poly (ADP-ribose) polymerase (PARP) expression levels were significantly higher in the PEG-iodine-silk/MD hydrogel group than in the other three groups (p < 0.001). Haematoxylin and eosin (H&E) staining showed no abnormalities in the heart, liver, spleen, lung, kidney, pancreas or thyroid in any group.Conclusions: Self-assembling imageable silk hydrogels could be injected locally into osteosarcoma tissues with X-ray assistance. With the advantages of good biosafety, low systemic toxicity and minimal invasiveness, self-assembling imageable silk hydrogels provide a promising approach for improving the locoregional control of osteosarcoma.

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Benefits of the povidone–iodine: Simultaneously decrease risk of infection and tumor seeding after percutaneous endoscopic gastrostomy

Cited by 2 publications

References 20 publications

Risk of Esophageal Cancer Following Percutaneous Endoscopic Gastrostomy in Head and Neck Cancer Patients

Risk of Esophageal Cancer Following Percutaneous Endoscopic Gastrostomy in Head and Neck Cancer Patients

Self-Assembling Imageable Silk Hydrogels for the Focal Treatment of Osteosarcoma

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