Benefits of turmeric supplementation for skin health in chronic diseases: a systematic review

Mata, Isabella Rosa da; Mata, Sheila Rosa da; Menezes, Rafaella Câmara Rocha; Faccioli, Larissa Slongo; Bandeira, Kathleen Krüger; Bosco, Simone Morelo Dal

doi:10.1080/10408398.2020.1798353

Cited by 12 publications

(5 citation statements)

References 39 publications

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“…Studies mentioning high-dose tetrahydrocurcumin (THC), which has higher antioxidant activity, have been shown in trials to overcome these limits [41]. Recent research has looked at the antiinflammatory and antioxidant properties of THC, a main active metabolite of curcumin, in the treatment of tumors and inflammatory illnesses [49][50][51]. Among the skin problems investigated are psoriasis, pruritus, oral lichen planus, facial redness, and numerous types of skin cancer [52].…”

Section: Curcuminmentioning

confidence: 99%

“…Cheng et al, 2001 conducted a phase 1 clinical trial to investigate the use of curcumin and skin cancer and discovered the harmful effects of oral consumption (>8000 mg/day) while treating in a dose-dependent way; patients' precancerous lesions improved histologically [58]. A dose-dependent effect was also discovered at nearly all dosage levels [51,58].…”

Section: Curcuminmentioning

confidence: 99%

See 1 more Smart Citation

Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why

Januszewski,

Forma,

Zembala

et al. 2023

Medicina

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Supplementation of micronutrients is considered to be crucial in the reinforcement of the skin’s barrier. In this paper, 14 nutritional compounds commonly used in food or pharmaceutic industries were analyzed in terms of influencing skin conditions. The major objective of this paper was to provide a narrative review of the available literature regarding several chosen compounds that are currently widely recommended as supplements that aim to maintain proper and healthy skin conditions. We conducted a review of the literature from PubMed, Scopus, and Web of Science until September 2023 without any other restrictions regarding the year of the publication. Ultimately, we reviewed 238 articles, including them in this review. Each of the reviewed compounds, including vitamin A, vitamin C, vitamin D, vitamin E, curcumin, chlorella, Omega-3, biotin,Ppolypodium leucotomos, Simmondsia chinesis, gamma oryzanol, olive leaf extract, spirulina, and astaxanthin, was observed to present some possible effects with promising benefits for a skin condition, i.e., photoprotective radiation. Adding them to the diet or daily routine might have a positive influence on some skin inflammatory diseases such as atopic dermatitis or psoriasis. Further, UV radiation protection facilitated by some supplements and their impact on human cells might be helpful during chemotherapy or in preventing melanoma development. Further research is needed because of the lack of clear consensus regarding the doses of the described compounds that could provide desirable effects on the skin.

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Section: Curcuminmentioning

confidence: 99%

Section: Curcuminmentioning

confidence: 99%

Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why

Januszewski,

Forma,

Zembala

et al. 2023

Medicina

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“…14,15 In recent years, many studies have validated that turmeric/CUR products and supplements, whether applied topically or taken orally, can offer therapeutic advantages for skin health. 16,17 This review aims to encapsulate the progress in CUR for treatment and management of skin disorders, offering insights that could guide both therapeutic practices and future clinical and foundational research in the realm of skin disorders. complex genetic, immunological, and environmental interactions that activate plasmacytoid dendritic cells, triggering dysregulated immune responses, excessive keratinocyte proliferation, and the production of proinflammatory cytokines such as tumor necrosis factor (TNF)-α, interferon (IFN)-γ, IL-17, IL-22, IL-23, and IL-1β, which in turn stimulate further keratinocyte hyperproliferation and perpetuate chronic inflammation.…”

Section: Introductionmentioning

confidence: 99%

Advancements in Dermatological Applications of Curcumin: Clinical Efficacy and Mechanistic Insights in the Management of Skin Disorders

Mo,

Yuan,

Guan

et al. 2024

CCID

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Curcumin, derived from Curcuma longa (turmeric), exhibits significant potential in dermatology, addressing conditions like atopic dermatitis, psoriasis, chronic wounds, skin cancer, and infections through its anti-inflammatory, antioxidant, anticancer, and antimicrobial properties. This review synthesizes evidence on curcumin's mechanisms, including modulation of immune responses and promotion of wound healing, showcasing its efficacy in reducing inflammation, cytokine levels, and enhancing skin barrier functions. Studies highlight curcumin's ability to selectively target tumor cells, suggesting a multifaceted approach to cancer therapy with minimal side effects. Despite promising therapeutic benefits, challenges remain in bioavailability, potency, and targeted delivery, underscoring the need for further research to optimize dosages, delivery methods, and assess long-term safety. The integration of curcumin into dermatological practice requires a balanced consideration of evidence-based efficacy and safety. Curcumin's comprehensive utility in dermatology, coupled with the necessity for advanced scientific exploration, emphasizes the importance of combining traditional knowledge with contemporary research to improve patient care in dermatology. This approach could significantly enhance outcomes for individuals with skin-related conditions, marking curcumin as a versatile and promising agent in the field.

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“…A plethora of health benefits are reported to be associated with consumption of turmeric preparations (extracts and/or oils), such as improvement of skin health and the potential to treat a variety of ailments including gastrointestinal disorders, autoimmune diseases, and cancers (Ammon & Wahl, 1991; EMA, 2018; Rosa da Mata et al, 2021; Vaughn et al, 2016). These effects are widely attributed to curcumin (one of the three principal curcuminoids found in turmeric, along with demethoxycurcumin and bisdemethoxycurcumin—see Figure 1), which has been demonstrated to exert physiologically beneficial effects, primarily by antioxidant and anti‐inflammatory mechanisms (Alvarenga et al, 2020; Heshmati et al, 2020; Lin et al, 2007; Saraf‐Bank et al, 2019; Shafabakhsh et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies

Phipps

Bali

Kukadia

et al. 2023

J of Applied Toxicology

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Curcumin, one of the three principal curcuminoids found within turmeric rhizomes, has long been associated with numerous physiologically beneficial effects; however, its efficacy is limited by its inherently low bioavailability. Several novel formulations of curcumin extracts have been prepared in recent years to increase the systemic availability of curcumin; Longvida®, a solid lipid curcumin particle preparation, is one such formulation that has shown enhanced bioavailability compared with standard curcuminoid extracts. As part of a safety assessment of Longvida® for use as a food ingredient, a bacterial reverse mutation test (OECD TG 471) and mammalian cell erythrocyte micronucleus test (OECD TG 474) were conducted to assess its genotoxic potential. In the bacterial reverse mutation test, Longvida® did not induce base‐pair or frame‐shift mutations at the histidine locus in the genome of Salmonella typhimurium strains TA98, TA100, TA102, TA1535, and TA1537, in the presence or absence of exogenous metabolic activation. Additionally, two gavage doses (24 h apart) of Longvida® to Swiss albino mice at 500, 1000, or 2000‐mg/kg body weight/day did not cause structural or numerical chromosomal damage in somatic cells in the mammalian erythrocyte micronucleus test. It was therefore concluded that Longvida® is non‐genotoxic.

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Benefits of turmeric supplementation for skin health in chronic diseases: a systematic review

Cited by 12 publications

References 39 publications

Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why

Nutritional Supplements for Skin Health—A Review of What Should Be Chosen and Why

Advancements in Dermatological Applications of Curcumin: Clinical Efficacy and Mechanistic Insights in the Management of Skin Disorders

Safety assessment of a solid lipid curcumin particle preparation: In vitro and in vivo genotoxicity studies

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