Benefits of Vitamin D in Health and Diseases

Passeri, Giovanni; Giannini, Sandro

doi:10.3390/nu15112419

Nutrients

2023

DOI: 10.3390/nu15112419

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Benefits of Vitamin D in Health and Diseases

Giovanni Passeri

Sandro Giannini

Abstract: This Special Issue of Nutrients, titled “Benefits of Vitamin D in health and diseases”, includes a total of twenty-five publications that consider different aspects of vitamin D, both at the cellular/preclinical and clinical levels, in neonates or children, in pregnant women, in adults and in elderly subjects [...]

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2024

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Cited by 4 publications

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Sex-related differences in vitamin D testing in the Veneto Region, Italy: a retrospective analysis from 2005 to 2016

Giannini,

Pitino,

Sella

et al. 2024

Arch Osteoporos

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Summary A retrospective analysis was performed to evaluate the frequency of vitamin D blood testing in individuals from the Padua province, Veneto, Italy from 2005 to 2016. A significant increase in the frequency of vitamin D blood tests, particularly in females was observed and in individuals with severe vitamin D deficiency (Class I). Purpose Vitamin D deficiency has been linked to negative health outcomes that extend beyond bone-related conditions. The frequency of vitamin D blood testing in residents from the Padua province, (Veneto, Italy) from 2005 to 2016 was evaluated. Methods Data were retrospectively retrieved from blood test databases (Laboratory Medicine Unit, Padua University Hospital) and information on number of vitamin D blood tests performed on residents from 2005 to 2016 was collected. Data were stratified by sex and ten birth cohorts from 1901 to 2016. Blood tests were classified into five vitamin D classes: I < 50 nmol/L, II 50–74.9 nmol/L, III 75–149 nmol/L, IV 150–250 nmol/L, and V > 250–1000 nmol/L. Blood test trends were analyzed as blood test rate and vitamin D class rate/resident population. Population analysis was analyzed by incidence rates and stratified by vitamin D class. Results 293,013 vitamin D blood tests were conducted between 2005 and 2016 across 10 birth cohorts. Females accounted for 75% of tests and fewer were conducted in the youngest and oldest birth cohorts. Sex differences in vitamin D blood test frequency were observed; adjusted rates ranging from 1.7 to 35.6% for males and 8 to 81% for females from 2005 to 2016. Crude incidence rates (per 1000 from 2005 to 2016) varied from 1.5 to 10.8‰ for males and 7 to 19.4‰ for females. Crude blood test rates for vitamin D deficiency (Class I) increased from 1.1 to 9.9‰ in 2016 for males and 5 to 17.3‰ for females. Crude incidence rates (from 2005 to 2016) for Class I were 9.7–57.1‰ in males and 43.6–92.4‰ in females. Conclusions These findings highlight sex-related differences in vitamin D testing, providing valuable insight for healthcare planning.

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Sex-related differences in vitamin D testing in the Veneto Region, Italy: a retrospective analysis from 2005 to 2016

Giannini,

Pitino,

Sella

et al. 2024

Arch Osteoporos

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Prediction of Vitamin D and Serotonin levels with increased risk Depressive in Adolescent Students

Wajid,

Sharba

2024

BIO Web Conf.

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Vitamin D deficiency (Vt.D) is common in adolescents and is influenced by some factors, including puberty. It impacted serotonin levels, thus increasing the risk of depression. This study was conducted to assess the association between vitamin D deficiency and depression and its effect on adolescent students. A cross-sectional study of 130 adolescent students aged 12-18 years, between November 2023 to February 2024. This study investigated serum Vt.D, serotonin levels, and hematological indices such as (RBC, Hb, MCV, and MCH, of adolescents, in addition, it was dependent on the Beck Depression Inventory to calculate scales of depression. 130 adolescent students were enrolled aged 12-18, mean ± SD: 14.85±2.19. The results indicated that 77(59.2%) students had depression symptoms, median (IQR) of scores16(13₋21.5), and 53(40.8%) adolescents with non-depressed (scores 5(2.5₋7), who were considered as the control group, a statistically significant between these groups (p=0.035). Depression was significantly more prevalent in females 46(59.7%) than males 31(40.3%), p=0.014. Deficiency Vt.D was found in 63.6% of the total depressive adolescents and was significantly more than nondepressive adolescents 3.8%, p<0.0001, with (B: 3.199, OR: 24.5, 95%CI: 5.96 -100.74). Serum Vt.D level was significantly decreased in depressive adolescent median (IQR) 18.8(13.1 ₋28.9) ng/ml, compared with non-depressed 52.22(42.2₋62.4), (p< 0.0001), and its lowest in a type of severe depression 10.74±3.52. The depressive adolescent group had significantly lower serotonin levels in deficiency Vt.D status than non-depressive groups (143.39±60.91 vs. 314.05±46.11), p = 0.001). Correlations and linear regression analysis to predict the risk factors for depression scores showed a significant negative correlation with levels of Vt.D (r=0.786, B: -0.109, 95%CI: -0.15 to -0.065, p<0.0001), and serotonin (r=0.848, B: 0.003, 95%CI: -0.032 to -0.019, p<0.0001), respectively. Deficiency Vt.D is an important risk factor for adolescents, especially in females, and is associated with an increased risk of depression in adolescent students

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Chronic Atrophic Autoimmune Gastritis: The Evolving Role of Vitamin D

Aggeletopoulou,

Konstantakis,

Triantos

2024

Front. Biosci. (Landmark Ed)

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Vitamin D possesses a crucial role in preserving bone health, modulating the immune system responses, and supporting various physiological functions throughout the body. Chronic atrophic autoimmune gastritis (CAAG) constitutes an autoimmune condition marked by inflammation and damage to the stomach cells, often resulting in a decreased ability to absorb certain nutrients, including vitamin B12 and iron. Although, vitamin D is not directly affected by this condition, the sufficiency of this micronutrient seems to have important implications for overall health and management of the disease. The aim of the current review was to assess the incidence and related features of vitamin D deficiency in patients with CAAG and to elucidate the complex regulatory role of this nutrient, in an effort to improve patient outcomes. Vitamin D greatly contributes to the regulation of the immune system. In patients with CAAG, the immune system attacks the stomach lining; thus, the maintenance of a healthy and balanced immune response is important. In autoimmune conditions such as CAAG, where inflammation plays a decisive role in disease progression, vitamin D could potentially exert a role in managing and controlling the associated symptoms. Adequate vitamin D levels may help in regulating the immune response and reducing inflammation. In addition, patients with CAAG are at risk of nutrient deficiencies, including vitamin B12 and iron, which can lead to anemia and bone health issues. As vitamin D is critical for calcium absorption and bone health, assurance of sufficient levels of this micronutrient can be beneficial in preventing or mitigating bone-related complications. In conclusion, regular monitoring of vitamin D levels, among other nutrients, and appropriate supplementation, when necessary, can help improve overall health and well-being in these patients.

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Benefits of Vitamin D in Health and Diseases

Cited by 4 publications

References 35 publications

Sex-related differences in vitamin D testing in the Veneto Region, Italy: a retrospective analysis from 2005 to 2016

Sex-related differences in vitamin D testing in the Veneto Region, Italy: a retrospective analysis from 2005 to 2016

Prediction of Vitamin D and Serotonin levels with increased risk Depressive in Adolescent Students

Chronic Atrophic Autoimmune Gastritis: The Evolving Role of Vitamin D

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