Benign and Malignant Oncocytoma of the Salivary Glands with an Immunohistochemical Evaluation of Ki-67

Itō, Keiko; Tsukuda, Mamoru; Kawabe, Ryoichi; Nakagawa, Chihiro; Matsushita, Kazunobu; Kubota, Akira; Furukawa, Madoka; Kameda, Yoichi; Ito, Takaaki

doi:10.1159/000027766

Cited by 33 publications

(11 citation statements)

References 5 publications

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“…They concluded that ki-67 may assist in differentiating malignant from benign laryngeal epithelium lesions. A similar result was obtained by Ito et al [15] for distinguishing a benign oncocytoma from a malignant form. TLI is a kinetic parameter and radioactive thymidine incorporates into DNA in the S phase of the cell cycle so it is possible to determine the labeled proliferating cell ratio in a cell population [2].…”

Section: Discussionsupporting

confidence: 86%

Thymidine Labeling Index in Laryngeal Squamous Cell Carcinoma in Correlation with pTNM, Age, Histological Grade and Recurrence

Ünal

Bılır²,

Karatay

2002

ORL

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In this study, our aim was to investigate the prognostic features of the thymidine labeling index (TLI) in laryngeal squamous cell carcinoma (SCC). The TLI values in tumor tissues and adjacent healthy tissues were assessed in 40 patients who had a pathological diagnosis of laryngeal SCC. The data were correlated with age, pTNM, histological grade and recurrence. The tissues (tumor and adjacent tumor-free tissue) obtained during surgery were labeled with ³H-thymidine. A statistically significant difference was observed between tumoral tissue and adjacent tumor-free tissue (p < 0.05), but we could not confirm any statistically significant correlation between TLI and age, pTNM, histological grade and recurrence. In conclusion, TLI in laryngeal SCC had no significant relation with the clinicopathological features, probably due to the variation in tissue sampling and for tumor-dependent reasons. TLI may assist in differentiating malignant from benign lesions.

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Section: Discussionsupporting

confidence: 86%

Thymidine Labeling Index in Laryngeal Squamous Cell Carcinoma in Correlation with pTNM, Age, Histological Grade and Recurrence

Ünal

Bılır²,

Karatay

2002

ORL

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“…The prognostic importance of Ki67 has been emphasized in relation to various neoplasias, like prostate cancer [14], gastrointestinal stromal tumors [25], breast cancer [26], and parotid gland tumors [27]. Loro et al [28]compared Ki67 expression in snuff-using and non-snuff-using oral squamous cell carcinoma patients in Norway and Sudan.…”

Section: Discussionmentioning

confidence: 99%

Changes in Apoptosis and Mitotic Index, p53 and Ki67 Expression in Various Types of Oral Leukoplakia

Kövesi

Szende

2003

Oncology

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Introduction: Leukoplakia is the most frequent pre-blastomatous alteration in the oral cavity. Its potential for malignant transformation is unpredictable. The aim of the present study was to provide data about the processes and molecular genetic background of this disease. Materials and Methods: Leukoplakias of 15 patients and oral squamous cell carcinomas of 3 patients treated at the Department of Periodontology and Oral Surgery, Semmelweis University, were studied by histological and immunohistochemical methods. The samples were fixed in 4% formalin and embedded in paraffin. Hematoxylin and eosin staining, TUNEL reaction (Apop-Detect kit), and immunohistochemical reactions for Ki67 and p53 were applied. The severity of dysplasia, the mitotic and apoptotic indices and expression as well as distribution of Ki67 and p53 were examined and compared to the clinical appearance of leukoplakia. Results: The mitotic and apoptotic indices and Ki67 expression increased significantly in parallel with the severity of dysplasia and also with the clinical stage (homogenous, nodular, erythroleukoplakia). The positivity and intracellular localization of (mutant) p53 varied according to the clinical form of leukoplakia. Homogenous and nodular forms showed cytoplasmic staining, while erythroleukoplakia and carcinoma cases were characterized by nuclear positivity. Conclusions: The increased apoptotic and Ki67 indices may indicate an unfavorable prognosis for leukoplakia. The expression of Ki67 and p53 in various forms of leukoplakia point to the increasing instability of the genome in parallel with the severity of leukoplakia.

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“…It has been demonstrated that the frequency of Ki-67-positive cells was significantly higher in malignant salivary gland tumours compared with that in benign tumours of the salivary gland. 7 Ito et al 8 also demonstrated that Ki-67 immunostaining was useful in distinguishing a benign from malignant oncocytoma.…”

Section: Discussionmentioning

confidence: 98%

“…Ito et al. 8 also demonstrated that Ki‐67 immunostaining was useful in distinguishing a benign from malignant oncocytoma.…”

Section: Discussionmentioning

confidence: 98%

Fine needle aspiration cytology of oncocytic carcinoma of the submandibular gland with pre‐existing oncocytoma: a case report

Lee

Chang

2010

Cytopathology

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Benign and Malignant Oncocytoma of the Salivary Glands with an Immunohistochemical Evaluation of Ki-67

Cited by 33 publications

References 5 publications

Thymidine Labeling Index in Laryngeal Squamous Cell Carcinoma in Correlation with pTNM, Age, Histological Grade and Recurrence

Thymidine Labeling Index in Laryngeal Squamous Cell Carcinoma in Correlation with pTNM, Age, Histological Grade and Recurrence

Changes in Apoptosis and Mitotic Index, p53 and Ki67 Expression in Various Types of Oral Leukoplakia

Fine needle aspiration cytology of oncocytic carcinoma of the submandibular gland with pre‐existing oncocytoma: a case report

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