Benign Breast Biopsy Diagnosis and Subsequent Risk of Breast Cancer

Ashbeck, Erin L.; Rosenberg, Robert D.; Stauber, Patricia M.; Key, Charles R.

doi:10.1158/1055-9965.epi-06-0394

Cited by 58 publications

(37 citation statements)

References 33 publications

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“…In 298 women with SA, they saw no increased risk of subsequent breast cancer [4]. Ashbeck et al [18] examined benign breast biopsy diagnoses in the New Mexico Mammography Project and observed a hazard ratio for breast cancer of 2.28 (95 % CI 1.64–3.17) in patients with SA. In that study, however, histologic diagnoses were abstracted from the text of archival pathology reports and not confirmed by central pathology review.…”

Section: Discussionmentioning

confidence: 99%

Sclerosing adenosis and risk of breast cancer

Visscher

Nassar

Degnim

et al. 2014

Breast Cancer Res Treat

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Over one million American women have a benign breast biopsy annually. Sclerosing adenosis (SA) is a common, but poorly understood benign breast lesion demonstrating increased numbers of distorted lobules accompanied by stromal fibrosis. Few studies of its association with breast cancer have been conducted, with contradictory results. We studied SA in the Mayo Benign Breast Disease (BBD) Cohort, which includes women who had benign biopsies at Mayo-Rochester 1967–2001. Breast cancer risk in defined subsets was assessed using standardized incidence ratios (SIRs), relative to the Iowa Surveillance, Epidemiology, and End Results registry. This BBD cohort of 13,434 women was followed for a median of 15.7 years. SA was present in 3,733 women (27.8 %) who demonstrated an SIR for breast cancer of 2.10 (95 % CI 1.91–2.30) versus an SIR of 1.52 (95 % CI 1.42–1.63) for the 9,701 women without SA. SA was present in 62.4 % of biopsies with proliferative disease without atypia and 55.1 % of biopsies with atypical hyperplasia. The presence of SA stratified risk in subsets of women defined by age, involution status, and family history. However, SA does not further stratify risk in women diagnosed with other forms of proliferative breast disease, either with or without atypia. SA is a common proliferative lesion of the breast which, as a single feature, conveys an approximate doubling of breast cancer risk. Its role in breast carcinogenesis remains undefined; its presence may aid in risk prediction for women after a breast biopsy.

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Section: Discussionmentioning

confidence: 99%

Sclerosing adenosis and risk of breast cancer

Visscher

Nassar

Degnim

et al. 2014

Breast Cancer Res Treat

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“…In our study, the median length of follow-up of 10.37 years was half that of the Nashville study. However, one recent study drawn from the New Mexico Tumor Registry, reported that fibroadenoma, grouped as a low-risk category with other proliferative lesions without atypia such as hyperplasia and adenosis, did not show an association with subsequent breast cancer development (30). Another, found a low incidence of malignancy in complex fibroadenomas at a mean follow-up of 2 years (28).…”

Section: Discussionmentioning

confidence: 99%

Risk factors for breast cancer from benign breast disease in a diverse population

Worsham

Raju

Lü

et al. 2008

Breast Cancer Res Treat

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Summary Background The majority of studies have reported risks of breast cancer from benign breast disease (BBD) in essentially homogenous Caucasian populations. Information on breast cancer risk factors in larger, multi-ethnic populations should facilitate the development of appropriate and targeted risk reduction strategies. Design Cases and controls were drawn from a parent BBD cohort of 4,970 women, 1,341 African Americans (AA) and 3,629 non-AA who were diagnosed with BBD after examination of an excisional breast biopsy. Risk factors (34 variables) included demographics, lesion types, and epidemiological variables. Results The final multivariable model retained significance (p<0.05) for lesion risk-level, fibroadenoma, and the interaction of age-by-race. Women with proliferative lesions (no atypia, risk level 2) were 1.7 times more likely to develop BC when compared with women with non-proliferative lesions (OR=1.7, 95% CI 1.13, 2.42, p=0.009). Women with atypia (risk level 3) were 3.75 times more likely to develop BC compared to women with non-proliferative lesions (OR= 3.75, 95% CI 1.99, 7.06, p<.001). The odds of breast cancer was approximately 35% lower among women with fibroadenoma as compared to women without fibroadenoma (OR=0.65, 95% CI 0.46, 0.94, p=0.020). African-American women with BBD who were 50 years or older were 2.28 times more likely to develop breast cancer as compared to non African-American women who were less than 50 years old (OR=2.28, 95% CI 1.34, 3.88, p=0.002). Conclusion Women with fibroadenoma (nonproliferative or proliferative) were less likely to progress to BC. Older African American women are at greater risk for progression to breast cancer from BBD.

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“…Dupont et al [17] showed that adult women with fibroadenomas have a higher risk for developing breast cancer than women of similar age in the general population. Another large study stated that fibroadenomas did not exhibit an association with breast cancer development [18].…”

Section: Discussionmentioning

confidence: 99%