Benign cough headache is responsive to acetazolamide

Wang, Shuu Jiun; Fuh, Jong‐Ling; Lu, Shiang‐Ru

doi:10.1212/wnl.55.1.149

Cited by 50 publications

(41 citation statements)

References 6 publications

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“…Occipital nerve stimulation also appears to be a safe and effective treatment for HC [78]. Cough headache has been treated effectively with acetazolamide [79] and methysergide [80] in open-label trials. Propranolol has been used to treat exercise [40] and sex headaches [81].…”

Section: Indomethacin Pharmacologymentioning

confidence: 99%

Indomethacin-Responsive Headaches

VanderPluym

2014

Curr Neurol Neurosci Rep

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Indomethacin-responsive headaches are a heterogeneous group of primary headache disorders distinguished by their swift and often absolute response to indomethacin. The epidemiology of these conditions is incompletely defined. Traditionally, indomethacin-responsive headaches include a subset of trigeminal autonomic cephalalgias (paroxysmal hemicrania and hemicrania continua), Valsalva-induced headaches (cough headache, exercise headache, and sex headache), primary stabbing headache, and hypnic headache. These headache syndromes differ in extent of response to indomethacin, clinical features, and differential diagnoses. Neuroimaging is recommended to investigate for various organic causes that may mimic these headaches. Case reports of other primary headache disorders that also respond to indomethacin, such as cluster headache, nummular headache, and ophthalmoplegic migraine, have been described. These "novel" indomethacin-responsive headaches beg the question of what headache characteristics are required to qualify a headache as an indomethacin-responsive headache. Furthermore, they challenge the concept of using a therapeutic intervention as a diagnostic criterion.

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Section: Indomethacin Pharmacologymentioning

confidence: 99%

Indomethacin-Responsive Headaches

VanderPluym

2014

Curr Neurol Neurosci Rep

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“…In addition to the transient increased intracranial pressure, crowdedness of the posterior fossa and cerebrospinal fluid (CSF) hypervolemia have also been postulated to be potential causes of PCH [30,31]. Some have proposed that impaired myogenic cerebrovascular autoregulation might be the central mechanism for EH, whereby EH might be caused by an aberrant vasodilatation during or following exercise [32].…”

Section: Pathophysiologymentioning

confidence: 99%

“…The maximum dose ranges from 1125 to 2000 mg per day, and maintenance of dosage can be adjusted based on responsiveness [31]. The CSF drainage should be reserved as the second-line treatment only after failure of medications because of the invasiveness of the procedure [39].…”

Section: Primary Cough Headachementioning

confidence: 99%

The “Other” Headaches: Primary Cough, Exertion, Sex, and Primary Stabbing Headaches

Wang

Fuh

2010

Curr Pain Headache Rep

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Primary cough headache, primary exertional headache, primary sexual headache, and idiopathic stabbing headache are included in "Other Primary Headaches" (Group 4) in the International Classification of Headache Disorders, 2nd edition (ICHD-II). Headaches provoked by cough, exertion, and sex have different age distributions, but they do share some clinical and pathogenic characteristics. The triggering activities frequently involve Valsalva-like maneuvers, which may explain part of the pathogenesis. Primary stabbing headache is common and characterized by ultra-short stabbing headaches. All these headache disorders respond well to indomethacin, and they are commonly comorbid with migraine except for primary cough headache. Of note, some patients with sexual headache had reversible cerebral vasoconstriction syndromes. Recent large-scaled studies have revealed that the ICHD-II criteria of these four headache disorders cannot be completely fulfilled. Further revisions for the ICHD-II criteria are required based on these results of the evidence-based studies.

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“…The possibility of a sudden increase in venous pressure being sufficient itself to cause headache due to an increase in brain volume has been proposed [28]. However, there should be other contributing factors such as a hypersensitivity of some receptors that are sensitive to pressure and hypothetically localized on the venous vessels [29].…”

Section: Pathophysiologymentioning

confidence: 99%

Primary cough headache

Pascual

2005

Current Science Inc

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Primary cough headache is defined as head pain brought on by coughing or other Valsalva maneuvers, but not by prolonged physical exercise, in the absence of any intracranial disorder. Primary cough headache is considered to be a rare condition, accounting for 0.4% of all headaches consulting our Neurology Department. Its pathophysiology remains a mystery. Primary cough headache is a sudden-onset headache that usually lasts from 1 second to 30 minutes, tends to be bilateral and posterior, does not begin earlier than the fifth decade of life, is more frequent in men, is not accompanied by other neurologic manifestations, and responds to indomethacin. These clinical characteristics allow its differential diagnosis from other entities, even though a craniocervical magnetic resonance imaging study is mandatory to rule out posterior fossa lesions, especially Chiari type-I malformation.

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Benign cough headache is responsive to acetazolamide

Cited by 50 publications

References 6 publications

Indomethacin-Responsive Headaches

Indomethacin-Responsive Headaches

The “Other” Headaches: Primary Cough, Exertion, Sex, and Primary Stabbing Headaches

Primary cough headache

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