Benign Cutaneous Pseudoglandular Schwannoma

Deng, April; Petrali, John P.; Jaffe, David; Sina, Bahram; Gaspari, Anthony A.

doi:10.1097/01.dad.0000175534.73110.4e

Cited by 23 publications

(18 citation statements)

References 7 publications

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“…This is a still poorly recognized variant which at first glance, may be misconstrued as a glandular schwannoma (5, 6). The pseudoepithelial lining reportedly exhibited no reactivity for cytokeratin and epithelial membrane antigen in the presence of schwann cell‐related markers (1–4), a finding confirmed by the present study. It must be noted, however, the coexistence of a minor pseudoglandular area with true glands in a case of glandular schwannoma (6).…”

Section: Commentssupporting

confidence: 88%

“…including ours, consisted of cellular Antoni A tissue (1)(2)(3). Foam cell collection and hemosiderin deposition in the present tumor further support the degenerative origin of pseudoglands (4).…”

Section: Intraparotid Pseudoglandular Schwannomasupporting

confidence: 72%

“…In contrast, irregularly branching cystic spaces in a pseudoglandular variant may originate from central breakdown of Verocay bodies (2). This idea seems circumstantially quite logical and is better explained by the fact that all reported lesions, including ours, consisted of cellular Antoni A tissue (1–3). Foam cell collection and hemosiderin deposition in the present tumor further support the degenerative origin of pseudoglands (4).…”

Section: Commentsmentioning

confidence: 77%

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Intraparotid pseudoglandular schwannoma

Ide

Obara

Mishima

2006

J Oral Pathology Medicine

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A unique intraparotid location of a rare pseudoglandular schwannoma is described. Although the diagnosis of schwannoma could readily be substantiated, accurate subtyping was initially mislabeled. The pitfall was in failing to acknowledge the presence of multiple well-formed gland-like structures, which is instantly thought to be cystically dilated salivary ducts. Immunohistochemically, epithelial-appearing cells lining the duct-like spaces proved to be schwannian in nature. Interpretation of an immediately recognizable gland-like architecture is more problematic when a pseudoglandular variant originates from a nerve coursing through the gland, as here.

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Section: Commentssupporting

confidence: 88%

Section: Intraparotid Pseudoglandular Schwannomasupporting

confidence: 72%

Section: Commentsmentioning

confidence: 77%

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Intraparotid pseudoglandular schwannoma

Ide

Obara

Mishima

2006

J Oral Pathology Medicine

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“…1 These variants are considered rare in the skin. Although isolated cases of cutaneous cellular schwannomas and cutaneous pseudoglandular schwannomas have been reported, [2][3][4][5] to our knowledge, this is the first published description of a cutaneous cellular pseudoglandular schwannoma.…”

Section: Introductionmentioning

confidence: 80%

Cutaneous Cellular Pseudoglandular Schwannoma

Sundarkrishnan

Bradish

Oliai

et al. 2016

The American Journal of Dermatopathology

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Cellular schwannoma and pseudoglandular schwannoma are both previously described rare variants of schwannoma. The authors present an unusual case of a cellular spindle cell neoplasm with prominent gland-like structures, having features of both variants. The nature of this lesion was confirmed by histology and immunohistochemistry, with diffuse and strong S100 and membranous collagen type IV staining. The gland-like structures were lined by S100 + cells and contained proteinaceous, mucicarmine-negative material, supporting a degenerative, not true glandular, phenomenon. This is the first case of a cutaneous schwannoma demonstrating both marked cellularity and pseudoglandular formation, which the authors have designated cutaneous cellular pseudoglandular schwannoma. Recognition of this extremely rare variant will help avoid diagnostic confusion and overtreatment of this benign entity.

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“…It has been shown, without doubt, that nerve sheath myxoma are separate and distinct from neurothekeomas The latter also include a myxoid variant, which immunohistochemically is NKI‐C3‐positive and S100‐negative and devoid of neurofilaments . Other differential diagnosis to be considered is vascular neoplasms in which pseudoglandular vascular spaces are labeled with endothelial markers such as CD31 …”

Section: Discussionmentioning

confidence: 99%

Microcystic pseudoglandular plexiform cutaneous neurofibroma

2015

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Glandular structures are well documented to appear in peripheral nerve sheath tumors. These epithelial elements are usually present in malignant peripheral nerve sheath tumors although a few cases of glandular benign peripheral nerve sheath tumors have also been described, most of them being schwannomas. A neurofibroma with glands is considered to be a rare type of divergent differentiation, but a neurofibroma containing gland-like or pseudoglandular structures have not, to our knowledge, been described. We report a 33-year-old patient with a well-demarcated dermal neoplasm, composed of neoplastic Schwann cells, perineurial-like cells and fibroblasts in a matrix with collagen fibers and myxoid areas. A part of the tumor consisted of microcystic gland-like spaces lined by flat cells. These cells were either S100 positive or negative, with no epithelial membrane antigen, cytokeratin or CD31 immunostaining. Recognition of the presence of pseudoglandular elements in neurofibromas is important to distinguish them from other tumoral lesions, some of them with malignant potential.

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Benign Cutaneous Pseudoglandular Schwannoma

Cited by 23 publications

References 7 publications

Intraparotid pseudoglandular schwannoma

Intraparotid pseudoglandular schwannoma

Cutaneous Cellular Pseudoglandular Schwannoma

Microcystic pseudoglandular plexiform cutaneous neurofibroma

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