Benign cylindroma causing transcalvarial invasion in a patient with familial cylindromatosis

Jh, Gildea; Ko, Lillehei; Le, Golitz; Bk, Kleinschmidt-DeMasters

doi:10.5414/npp26125

Cited by 3 publications

(1 citation statement)

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“…Clinical features that should be reported by patients as they are associated with cutaneous malignancy are as follows: tumour ulceration; rapid tumour growth; tumour pain; intermittent bleeding from a tumour, colour change in the surface of the tumour; tethering of the tumour to underlying bone. 26 Invasion through the skull plate has been observed, 27,28 supporting the use of radiological imaging in selected advanced CCS cases preoperatively. Malignant CCS tumours may metastasise to other tissues including the liver, lungs and bones.…”

Section: Malignancy In Ccsmentioning

confidence: 75%

Genetic Testing in CYLD Cutaneous Syndrome: An Update

Nagy¹,

Dubois²,

Széll³

et al. 2021

TACG

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Section: Malignancy In Ccsmentioning

confidence: 75%

Genetic Testing in CYLD Cutaneous Syndrome: An Update

Nagy¹,

Dubois²,

Széll³

et al. 2021

TACG

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Skull Invaders: When Surgical Pathology and Neuropathology Worlds Collide

Serracino

Kleinschmidt‐DeMasters

2013

J Neuropathol Exp Neurol

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Skull and dura serve as effective barriers to penetration by most tumors, often preventing masses originating intracranially from extending into the contiguous bone and soft tissues, or those arising in head and neck regions from extending into the dura and brain tissue. We review our 15-year experience with extracranial tumors that had sufficiently invaded adjacent skull, dura, or brain from the "outside-in" to require a neurosurgeon to participate in the surgical resection and discuss our 40 cases in context with the literature. Sinonasal-origin tumors (n = 17) and cutaneous tumors (n = 10) were the most frequent skull-invaders. Most of the cutaneous tumor types were squamous cellcarcinomas (n = 9); diverse sinonasal-origin types included 4 squamous cell carcinomas, 4 adenoid cystic carcinomas, 2 sinonasal undifferentiated carcinomas, 2 sinonasal adenocarcinomas, and single examples each of sinonasal-origin hemangiopericytoma, solitary fibrous tumor, melanoma, mucocele, and teratocarcinoma. There were 9olfactory neuroblastomas, and middle ear-origin basal cell carcinoma,recurrent glomus jugulare, and orbital malignant hidradenoma were also seen. Unique tumors included a cutaneous cylindroma invasive of skull convexity occurring in familial cylindromatosis and a ganglioneuroma of the middle ear with massive bilateral skull base extension. Convexity dural spread, a seldom-reported pattern of dissemination, was seen in 1 olfactory neuroblastoma and 1 adenoid cystic carcinoma. The ability to show skull/dural invasion did not correlate with specific histopathologic features; even benign tumor types can show skull/dural penetration.

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Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review

Kibe

Tanahashi

Ohtakara³

et al. 2022

BMC Neurol

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Background Eccrine spiradenocarcinoma (SC), also known as malignant eccrine spiradenoma, is a rare malignant cutaneous adnexal neoplasm arising from long-standing benign eccrine spiradenoma. Malignant skin tumors rarely show direct intracranial invasion. However, once the intracranial structure is infiltrated, curative excision with sufficient margins can become extremely difficult, particularly when the venous sinuses are involved. No effective adjuvant therapies have yet been established. Here, we report an extremely rare case of scalp eccrine SC with direct intracranial invasion, which does not appear to have been reported previously. Case presentation An 81-year-old woman presented with a large swelling on the parietal scalp 12 years after resection of spiradenoma from the same site. The tumor showed intracranial invasion with involvement of the superior sagittal sinus and repeated recurrences after four surgeries with preservation of the sinus. The histopathological diagnosis was eccrine SC. Adjuvant high-precision external beam radiotherapy (EBRT) proved effective after the third surgery, achieving remission of the residual tumor. The patient died 7 years after the first surgery for SC. Conclusions Scalp SC with direct intracranial invasion is extremely rare. Radical resection with tumor-free margins is the mainstay of treatment, but the involvement of venous sinuses makes this unfeasible. High-precision EBRT in combination with maximal resection preserving the venous sinuses could be a treatment option for local tumor control.

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Benign cylindroma causing transcalvarial invasion in a patient with familial cylindromatosis

Cited by 3 publications

References 0 publications

Genetic Testing in CYLD Cutaneous Syndrome: An Update

Genetic Testing in CYLD Cutaneous Syndrome: An Update

Skull Invaders: When Surgical Pathology and Neuropathology Worlds Collide

Direct intracranial invasion of eccrine spiradenocarcinoma of the scalp: a case report and literature review

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