Benign cystic mesothelioma of the peritoneum: A clinicopathologic study of 17 cases and immunohistochemical analysis of estrogen and progesterone receptor status

Sawh, Ravindranauth; Malpica, Anaís; Deavers, Michael T.; Liu, Jinsong; Silva, Elvio G.

doi:10.1053/hupa.2003.31

Cited by 117 publications

(139 citation statements)

References 35 publications

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“…Interestingly, PAX2 was also detected in these two ER-positive peritoneal mesotheliomas, but not in the PR-positive case in which the patient was a teenage girl. Whether this was due to aberrant expression of PAX2 [40][41][42] in malignant tumors, or Mü llerian metaplastic transformation of malignant mesotheliomas, 43,44 is under further investigation. Nevertheless, PAX2 might be useful as an additional immunohistochemical marker in the differential diagnosis of papillary serous carcinomas of the ovary and female malignant mesotheliomas of the peritoneum, with moderate sensitivity (67%) and specificity (88%).…”

Section: Discussionmentioning

confidence: 99%

Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?

et al. 2007

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PAX2 is a urogenital developmental transcription factor expressed in the Wolffian ducts, developing kidneys, and Mü llerian ducts during embryonic stage. Its function in renal development is well documented and its clinical application in the diagnosis of lesions of renal origin has been reported recently. However, information on its role in the Mü llerian-derived genital tract is sparse. In this study, we investigated the expression of PAX2 in human female genital tract using immunohistochemistry. We demonstrated that PAX2 was expressed specifically in the epithelial cells of fallopian tube, endometrial and endocervical glands, but not in the stromal tissues in these areas. PAX2 was detected in secondary Mü llerian structures in the ovary, such as endometriotic and endosalpingiotic glands and rete ovarii, but not in ovarian surface epithelium, surface epithelium-derived inclusion cysts, stroma, or sex-cord-derived structures such as follicles, oocytes, and corpus luteum. In addition, PAX2 was detected in 67% of ovarian papillary serous carcinomas (N ¼ 36) but rarely in peritoneal malignant mesotheliomas, with two exceptions (N ¼ 54). Interestingly, the two PAX2-positive 'peritoneal malignant mesotheliomas' were from female patients and were positive for estrogen receptor. The significance of expression of PAX2 and estrogen receptor in these cases is under investigation. Taken together, we suggest that PAX2 is a novel Mü llerian-specific epithelial marker when used in proper clinical settings. Identification of PAX2 in the majority of papillary serous carcinomas of the ovary but not in the ovarian surface epithelium or epithelium-derived inclusion cysts suggests that this malignant epithelial tumor may be directly derived from the primary or secondary Mü llerian epithelium in or surrounding the ovary, rather than from the surface epithelium or its derivatives.

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Section: Discussionmentioning

confidence: 99%

Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?

et al. 2007

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“…Cystic lymphangioma is more common in young males rather than females: the cystic spaces are lined by a single layer of flattened endothelial cells, which are immunoreactive against vascular antibodies, such as CD31 and CD34 [19,20]. In a few cases of BCM, nuclei of the activated mesothelial cells lined along the cyst wall were positive for ER and PR [19,21], our case was negative against both antibodies.…”

Section: Doi: 107243/2052-7896-5-5mentioning

confidence: 99%

A case of benign cystic mesothelioma arising from the lesser omentum in a 13-year-old girl treated through a laparoscope excision

Niwa¹,

Yano²,

Ueda³

et al. 2017

Pathol Discov

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Benign cystic mesotheliomas (BCMs) are extremely rare tumors usually occurring in females of reproductive age. A 13-year-old Japanese girl presented with abdominal pain, and an adnexal cystic tumor was suggested by images. At laparoscopy, the cystic mass was found arising from the lesser omentum. Histological examination and calretinin-immunohistochemistry revealed the lesion as a BCM. Cytology was initially useful for the diagnosis. This is a benign pathology, but recurrences are not uncommon. BCM should be included in the differential diagnosis, when investigating pelvic and abdominal masses associated with adnexal tumors in women.

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“…[7] Radiation, systemic or intraperitoneal chemotherapy, laser vaporization, percutaneous cyst drainage, hormone-therapy, sclero-therapy, or simple observation have been used with uncertain results. [3][4][5][6][7][8] Cytoreductive surgery and HIPEC, aiming at complete tumour eradication, is a new concept. Cytoreduction to microscopic or sub-millimetric tumour provides the optimal conditions for HIPEC to target minimal residual disease.…”

Section: Rational Basis For Comprehensive Treatment Of Multicystic Mementioning

confidence: 99%

“…[2] Multicystic peritoneal mesothelioma (MCPM) is an exceedingly rare lesion with uncertain malignant potential and an enigmatic natural history. [3][4][5][6][7] Approximately 150 cases of MCPM have been reported in the medical literature since it was first described by…”

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confidence: 99%

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Multicystic peritoneal mesothelioma: outcomes and patho-biological features in a multi-institutional series treated by cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Baratti

Vaira

Kusamura

et al. 2010

European Journal of Surgical Oncology

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Aim This retrospective multi-institutional study addresses the role of surgical cytoreduction and hyperthermic intraperitoneal chemotherapy (HIPEC) in the treatment of multicystic peritoneal mesothelioma (MCPM). MCPM is an uncommon tumour with uncertain malignant potential and no current standard therapy. Additionally, poorly defined pathological and biological features of this disease were investigated.Methods Twelve patients with MCPM underwent 14 procedures of cytoreduction and HIPEC in two Italian referral centres. Nine patients had recurrent disease after previous debulking (one operation in six patients, two in two, four in one). Biological markers related to mesothelioma origin and clinical features were assessed by immunohistochemical studies.Results Median follow-up was 64 months (range 5-148). Optimal cytoreduction (residual tumour nodules ≤2.5 mm) was performed in all the procedures. One grade IV postoperative complication (NCI/CTCAE v.3.0) and no operative death occurred. All the patients are presently alive with no evidence of disease, including two patients who underwent the procedure twice, due to locoregional disease recurrence. Five-and ten-year progression-free survival was 90% and 72%, accounting for a. statistically significant difference (P = .0001) with progression-free survival following previous debulking surgery (median 11 months; range 2-31). All cases showed low proliferative activity assessed by mitotic rate and Ki-67 expression.Conclusions MCPM is a borderline tumour with a high propensity to local-regional recurrence. Definitive tumour eradication by means of cytoreduction and HIPEC seems more effective than debulking surgery in preventing disease relapse. Low mitotic rate and poor Ki-67 expression might be related to the peculiar behaviour of MCMP.

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Benign cystic mesothelioma of the peritoneum: A clinicopathologic study of 17 cases and immunohistochemical analysis of estrogen and progesterone receptor status

Cited by 117 publications

References 35 publications

Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?

Expression of PAX2 in papillary serous carcinoma of the ovary: immunohistochemical evidence of fallopian tube or secondary Müllerian system origin?

A case of benign cystic mesothelioma arising from the lesser omentum in a 13-year-old girl treated through a laparoscope excision

Multicystic peritoneal mesothelioma: outcomes and patho-biological features in a multi-institutional series treated by cytoreductive surgery and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

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