Benign epileptiform discharges of childhood and associated conditions

Мухин, К. Ю.

doi:10.17650/2073-8803-2018-13-3-7-24

Cited by 3 publications

(1 citation statement)

References 45 publications

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“…Помимо типичной эпилептиформной активности по данным электроэнцефалографического исследования (ЭЭГ) при эпилепсии после ЧМТ могут регистрироваться графоэлементы, соответствующие критериям доброкачественных эпилептиформных паттернов детства (ДЭПД) [42]. ДЭПД не всегда клинически сопровождаются типичными тонико-клоническими приступами [43,44], хотя в 8-12% случаев и предшествуют развитию эпилепсии [45], которая, как правило, является возрастзависимой [43,46]. ДЭПД, равно Клинические наблюдения как и возрастзависимая эпилепсия, имеют особенность в виде исчезновения в пубертатном периоде [44].…”

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Severe brain trauma to the fetus in a car accident: Literature review and a clinical case

Vostrikov¹,

Ponomareva²,

Cheremisinov

et al. 2021

Alʹm. klin. med.

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Car accidents are the main cause of trauma during pregnancy. Even a non-severe accident is associated with a high risk of injury and unfavorable outcome for the fetus, especially in the event of placental abruption. Major agents leading to a trauma could also include safety belt and safety airbags. Blunt abdominal trauma during a car accident is associated with such type of intrauterine injury as fetal skull fractures and various intracranial hemorrhages. Despite a common viewpoint on relatively high death rates in this population, it is not infrequent that fetal trauma has a favorable outcome without any clinically significant neurological deficiency. The paper presents an analysis of the main outcomes of intrauterine brain injury and associated factors. As an illustration, we describe a case of a car accident related brain injury to a fetus at 38 week of gestation, with skull fracture, brain contusion, and subarachnoidal, epidural and subdural, parenchymal and intraventricular hemorrhages induced by the safety belt, with the mother being virtually uninjured. After treatment, the patient was discharged from the hospital in a satisfactory state, without clinically significant neurological symptoms and signs. A 8-months follow-up of the infant showed some delay in brain maturation manifesting as benign epileptiform discharges of childhood and magnetic resonance imaging patterns. It is highly likely, that the leading factors ensuring a favorable outcome of a intrauterine severe brain trauma (without fatal trauma to the mother and fetus) are as follows: correct obstetric strategy, late gestational age and absence of a massive parenchymal and/or intraventricular bleeding. After the short-term clinical recovery from a severe intrauterine brain trauma and in addition to it, proper follow-up of the child is essential because of a high risk of long-term cerebral and functional abnormalities, mostly paroxysmal, behavioral and cognitive.

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Severe brain trauma to the fetus in a car accident: Literature review and a clinical case

Vostrikov¹,

Ponomareva²,

Cheremisinov

et al. 2021

Alʹm. klin. med.

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The hypothesis of the functional disintegration of the brain due to the persistence of benign epileptiform patterns on the electroencephalogram

Садеков

Поляков

Садекова

et al. 2021

Rus. ž. det. nevrol.

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In this work, we have analyzed the results of observation of 200 children aged from 3 to 15 years old, who had various neuropsychiatric disorders in combination with benign childhood epileptiform patterns on the electroencephalogram. A hypothesis has been put forward about functional disorders of the developing nervous system with prolonged persistence of benign focal epileptiform discharge of childhood on electroencephalogram, mainly in slow-wave sleep. The possibilities of therapeutic correction of these disorders are discussed.

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The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech

Морозова

Belousova

Morozov

et al. 2022

Èpilepsiâ paroksizmalʹnye sostoâ.

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The article presents a case report, and a literature review on benign epileptiform discharges of childhood (BEDC) as well as effect of this type of epileptiform activity on speech, behavior and communication skills are analyzed. The incidence of BEDC comprises 5% in pediatric population. Examining children with autistic spectrum disorder, BEDC is revealed in 20% cases, whereas in those with attention deficit and hyperactivity disorder (ADHD) or speech disorder – in 25% and 18% cases, respectively. Many studies considering BEDC as a genetic marker of brain immaturity highlighted by different level of expressiveness and penetrance are discussed. It is highly probable that cognitive and speech disorders as well as ADHD in children with BEDC may be genetically determined. However, pediatric BEDC may be asymptomatic or become manifested by diverse psychoneurological symptoms accounted for by developed epileptic encephalopathy and continuous spike and waves during slow wave sleep (CSWS) requiring specialized long-term treatment. Markedly elevated CSWS with morphological BEDC affects interneuron connections, which, in turn, alters memory consolidation in mesial temporal regions. The literature analysis revealed that children with BEDC-like epileptic activity require obligatory periodic sleep electroencephalographic control and dynamic neuropsychological evaluation due to high incidence of speech, mnestic and behavioral disorders. Seizure-free BEDC-like epileptic activity should be corrected pharmaceutically only in case of established causative link with progressive cognitive impairments.

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Benign epileptiform discharges of childhood and associated conditions

Cited by 3 publications

References 45 publications

Severe brain trauma to the fetus in a car accident: Literature review and a clinical case

Severe brain trauma to the fetus in a car accident: Literature review and a clinical case

The hypothesis of the functional disintegration of the brain due to the persistence of benign epileptiform patterns on the electroencephalogram

The effect of benign epileptiform discharges of childhood on cognitive function, behavior and speech

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