Benign Exocrine Pancreatic Diseases in Inflammatory Bowel Diseases

Pezzilli, Raffaele; Pagano, Nico

doi:10.1159/000471481

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…[10][11][12] However, its prevalence varies among reported studies (0.04-4.5%). [13][14][15][16][17] Although data regarding the global prevalence of AIP are still lacking, 18 Japanese nationwide epidemiological survey of AIP demonstrated that the prevalence of AIP among general population was 10.1 per 100,000 persons, 18 suggesting a higher prevalence of AIP in patients with IBD.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and clinical features of patients with autoimmune pancreatitis and inflammatory bowel disease: A systematic review and meta‐analysis

Fukuda

Akiyama

Tarakji

et al. 2022

J of Gastro and Hepatol

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Background and Aim Autoimmune pancreatitis (AIP) and inflammatory bowel disease (IBD) are categorized into immune‐mediated inflammatory disorders (IMIDs). While AIP is a pancreato‐biliary IMID with an increased incidence and prevalence among patients with IBD, its features are still unclear. This systematic review and meta‐analysis aims to assess the prevalence and clinical characteristics of AIP‐IBD patients. Methods Electronic databases were searched to identify observational studies assessing AIP and IBD. The primary outcome was the prevalence of IBD among AIP patients, and vice versa. Secondary outcomes included clinical findings and outcomes of each IMID in AIP‐IBD patients. The pooled rate of each outcome was determined using a random effects model. Results For primary outcomes, 40 observational studies with 4031 AIP patients were included and the pooled prevalence of IBD was 10.5% (95% CI 7.2–15.0%). Meanwhile, five studies with 10,551 IBD patients were included and the pooled prevalence of AIP was 0.6% (95% CI 0.2–1.9%). For secondary outcomes, 53 observational studies with 469 AIP‐IBD patients were assessed. The rates of type 2 AIP and ulcerative colitis were 79.2% (95% CI 69.1–86.6%) and 74.8% (95% CI 68.2–80.4%), respectively. We also demonstrated AIP‐IBD patients were at a significant increased risk of AIP recurrence and colectomy compared with patients with either AIP or IBD (RR = 1.9, 95% CI 1.1–3.1 and P = 0.014 and RR = 3.7, 95% CI 1.9–6.9, P < 0.001, respectively). Conclusions Our meta‐analysis reported the prevalence of AIP‐IBD patients and demonstrated patients with both IMIDs had a high risk of poor outcomes.

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Section: Introductionmentioning

confidence: 99%

Prevalence and clinical features of patients with autoimmune pancreatitis and inflammatory bowel disease: A systematic review and meta‐analysis

Fukuda

Akiyama

Tarakji

et al. 2022

J of Gastro and Hepatol

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“…[ 12 ] However, a case series revealed no significant rise in the occurrence of pancreatitis among individuals with IBD when compared to the general population . [ 13 ] Hence, the existence of a causal relationship between IBD and acute pancreatitis remains uncertain.…”

Section: Introductionmentioning

confidence: 99%

Crohn disease but not ulcerative colitis increases the risk of acute pancreatitis: A 2-sample Mendelian randomization study

Fu,

Wu,

Shu

et al. 2024

Medicine

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Accumulating evidence has indicated an increased risk of acute pancreatitis in individuals with inflammatory bowel disease (IBD); however, the establishment of a clear and direct causal connection between IBD and acute pancreatitis remains uncertain. Utilizing genetic data from publicly accessible genome-wide association studies (GWAS), we conducted a 2-sample MR analysis to identify the associations between IBD, ulcerative colitis (UC), Crohn disease (CD), and acute pancreatitis risk. Rigorous quality control steps ensured the selection of eligible single nucleotide polymorphisms (SNPs) with strong associations to IBD. The primary estimation used the inverse-variance weighted method. We also assessed heterogeneity, potential pleiotropy, and conducted sensitivity analyses. The direction of causality was confirmed using the Steiger test. The MR analysis showed that IBD increased the risk of acute pancreatitis (IVW: OR = 1.032, 95% CI: 1.006–1.06, P = .015). Among the subgroup of IBD, CD (IVW: OR = 1.034, 95% CI: 1.008–1.06, P = .007) indicates a significant increase in the risk of acute pancreatitis compared to UC (IVW: OR = 1.02, 95% CI: 0.99–1.051, P = .189). The MR analysis assessing the association between CD and acute pancreatitis showed no evidence of heterogeneity or horizontal pleiotropy. Likewise, the leave-one-out (LOO) method indicated no significant influence of any individual SNP on the overall findings. In addition, the Steiger direction test revealed that CD was the cause for increased risk of acute pancreatitis, but not vice versa. In summary, this research pioneers in proposing a causal relationship between CD and acute pancreatitis among the European population.

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Inflammatory bowel disease and pancreatic diseases

Ribaldone¹

2020

Minerva Gastroenterol Dietol

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Benign Exocrine Pancreatic Diseases in Inflammatory Bowel Diseases

Cited by 3 publications

References 20 publications

Prevalence and clinical features of patients with autoimmune pancreatitis and inflammatory bowel disease: A systematic review and meta‐analysis

Prevalence and clinical features of patients with autoimmune pancreatitis and inflammatory bowel disease: A systematic review and meta‐analysis

Crohn disease but not ulcerative colitis increases the risk of acute pancreatitis: A 2-sample Mendelian randomization study

Inflammatory bowel disease and pancreatic diseases

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