Benign Fat Necrosis Simulating Bilateral Breast Malignancy After Reduction Mammoplasty

Miller, Jeffrey A.; Festa, Steven; Goldstein, Martin

doi:10.1097/00007611-199808000-00015

Cited by 22 publications

(7 citation statements)

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“…The forms of trauma inducing fat necrosis are many and varied, and often forgotten. Blunt trauma, cyst aspiration, massage, radiation therapy, biopsy, implant removal, lumpectomy, reduction mammoplasty, and breast reconstruction are all capable of causing fat necrosis 56,57 . Fat necrosis has even followed mammography, which requires squeezing the breasts 58 .…”

Section: Differential Diagnosismentioning

confidence: 99%

Idiopathic granulomatous lobular mastitis

et al. 2012

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Idiopathic granulomatous lobular mastitis (IGLM) is a rare breast condition with prominent skin findings. It is typically seen in young parous women. Painful breast masses, draining sinuses, scarring, and breast atrophy are the main clinical manifestations. IGLM can resemble a variety of other inflammatory and neoplastic processes of the breast. It is thought to result from obstruction and rupture of breast lobules. Extravasated breast secretions then induce an inflammatory reaction. Corynebacteria have also been implicated in the pathogenesis. Treatment is surgical, but systemic corticosteroids, methotrexate, and antibiotics also play a role.

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Section: Differential Diagnosismentioning

confidence: 99%

Idiopathic granulomatous lobular mastitis

et al. 2012

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“…The causes of fat necrosis in breasts are blunt trauma, cyst aspiration, biopsy, lumpectomy, radiation therapy, reduction mammoplasty, breast reconstruction, implant removal, and anticoagulant therapy, although it also can occur without a relevant cause. [17][18][19][20][21][22][23] Fat necrosis has a wide spectrum of clinical and radiologic appearances, varying from that of a benign oil cyst to that of a spiculated mass mimicking malignancy (Figures 5A, 6A, and 7A). 24,25 Histologically, there is local destruction of fat cells with the develop-Kim et al A B ment of variable-sized intracellular vacuoles filled with necrotic lipid material, which are surrounded by macrophages, multinucleated giant cells, and fibroblasts, forming the oil cysts.…”

Section: Fat Necrosismentioning

confidence: 99%

Spectrum of Sonographic Findings in Superficial Breast Masses

Kim

Suk

Kim

et al. 2005

Journal of Ultrasound in Medicine

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“…Such that fat necrosis may present as lipid cysts, coarse calcifications, microcalcifications, and focal asymmetries or even spiculated masses on mammography. [2][3][4][5][6] However, there are not yet enough experiences on FDG uptake in necrotic fat as well as fat necrosis appearances in PET/CT images. 5 Likewise, MRI appearances of fat necrosis may be indistinguishable from that of malignancy and can mimic tumor recurrence after breast sparing therapies.…”

Section: Discussionmentioning

confidence: 99%

Fat necrosis may mimic local recurrence of breast cancer in FDG PET/CT

Akkaş¹,

Vural²

2013

Revista Española de Medicina Nuclear e Imagen Molecular (Englis

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a b s t r a c tFat necrosis of the breast is a benign condition that most commonly occurs as the result of trauma. The radiographic and clinical significance of fat necrosis of the breast is that it may mimic malignancy.We present a case of false positive FDG PET/CT scan caused by fat necrosis and mimics local recurrence of breast carcinoma 3 years after radical mastectomy.Physicians must be aware of fat necrosis as a potential pitfall for PET/CT. Fat necrosis must be considered in the differential diagnosis of hypermetabolic breast masses in patients who previously had mastectomy or mammoplasty. La necrosis grasa puede asemejarse a una recurrencia local del cáncer de mama en la PET/TC con FDGPalabras clave: FDG PET/TC Carcinoma de mama Necrosis grasa Falso positivo r e s u m e n La necrosis grasa de mama constituye una situación benigna que se produce de forma común como resultado de un trauma. El significado radiográfico y clínico de la necrosis grasa puede asemejarse a una neoplasia.Presentamos el caso de un resultado falso positivo de la PET/TC con FDG debido a una necrosis grasa, y su semejanza con una recurrencia local de carcinoma de mama a los 3 años de una mastectomía radical.Los facultativos deben ser conscientes de que la necrosis grasa puede constituir una limitación para el estudio PET/TC. La necrosis grasa debe considerarse en el diagnóstico diferencial de las masas hipermetabólicas de mama en pacientes sometidas previamente a mastectomía o mamoplastia.

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Benign Fat Necrosis Simulating Bilateral Breast Malignancy After Reduction Mammoplasty

Cited by 22 publications

References 0 publications

Idiopathic granulomatous lobular mastitis

Idiopathic granulomatous lobular mastitis

Spectrum of Sonographic Findings in Superficial Breast Masses

Fat necrosis may mimic local recurrence of breast cancer in FDG PET/CT

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