Benign Fibrous Histiocytoma: A Rare Case Report and Literature Review

Abstract

Fibrous histiocytoma is a benign soft tissue tumour that may present as a fibrous mass anywhere in the human body. The involvement of the oral cavity is extremely rare and very few cases have been reported in literature till date. We here report a case of benign fibrous histiocytoma localized in the oral cavity. The clinical and histological features of the lesion are discussed precisely in the light of a literature review of this pathology in oral cavity.

Fibrous histiocytoma as first presentation in systemic lupus erythematosus and sero-positive Sjögren's syndrome

“… 2 It is the most common mesenchymal orbital tumor in adults, usually seen in middle-aged patients with mean age of 40 years. 3 The age and consistency of the mass in our patient matched with the description given in literature. Our patient had associated autoimmune disorders (SLE, vasculitis) and such association between FH and autoimmune disease is known.…”

A Case Report of a Benign Fibrous Histiocytoma: A Post-mosquito Bite Reaction

“…Immunohistochemical staining is essential in differentiating BFH from DFSP, as BFH stains are positive for factor XIIIa and negative for CD34. In contrast, DFSP stains are positive for CD34 and negative for XIIIa [ 6 ]. Therefore, a definitive diagnosis of BFH should be made by evaluating the tumor location; radiological characteristics such as the round, soft tissue mass seen in our patient; histopathological features; and immunohistochemical staining results.…”

Multiple benign fibrous histiocytomas of the mandible: A case report and review of the literature

“…Fibrous histiocytoma represents a group of diverse tumors, with both fibroblast and histiocytic differentiation, which was first described by Stout and Lattes ( 1 ) in 1967 ( 19 , 20 ). In the criteria of histological classification for bony tumors proposed by the WHO, 2nd edition, BFH was used to describe those independent tumors different from the connective tissue ones ( 2 , 13 , 21 ).…”

“…The etiology of mandible BFH remains to be fully established. According to certain experts, the tumor cells are derived from fibroblasts ( 24 ), while others assume that the tumor originates from the dendritic cells based on the evidence that the tumor is strongly positive for FXIIIa ( 20-23 ); furthermore, inflammation, viral infections and injuries may be major causes of bony BFH ( 25 , 26 ).…”