Benign Intracranial Hypertension Associated With Hypervitaminosis A

Feldman, Martin H.; Schlezinger, Nathan S.

doi:10.1001/archneur.1970.00480190005001

Cited by 75 publications

(24 citation statements)

References 79 publications

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“…In case-control studies, no association is found between IIH and multivitamin, oral contraceptive, corticosteroid or antibiotic use 10, 11. However, case reports associating some drugs appear convincing: nalidixic acid,16 nitrofurantoin,17 indomethacin18 or ketoprofen in Bartter's syndrome, 19 vitamin A intoxication,20 isotretinoin,21 thyroid replacement therapy in hypothyroid children,22 lithium23 and anabolic steroids 24. While corticosteroid use is not associated with intracranial hypertension, steroid withdrawal clearly is linked 12, 13…”

Section: Epidemiologymentioning

confidence: 99%

Idiopathic Intracranial Hypertension

2010

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Idiopathic intracranial hypertension ((IIH) is characterized by increased cerebrospinal fluid pressure of unknown cause. It is predominantly a disease of women in the childbearing years. Although the cause of IIH remains obscure, it has become clear that loss of visual function is common and patients may progress to blindness if untreated. Diagnosis should adhere to the modified Dandy criteria and other causes of intracranial hypertension sought. IIH patient management should include serial perimetry and optic disc grading or photography. The proper therapy can then be selected and visual loss prevented or reversed. Although there are no evidence-based data to guide therapy, there is an ongoing randomized double-blind controlled treatment trial of IIH investigating diet and medical therapy.

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Section: Epidemiologymentioning

confidence: 99%

Idiopathic Intracranial Hypertension

2010

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“…However, VA excess has been reported in the context of neural malfunction 25 . VA excess causes abnormally high brain pressure in humans 26 . Malfunction of neural tissues may be responsible for acute toxicity in Artemia .…”

Section: Discussionmentioning

confidence: 99%

Effect of light irradiation on dynamics of vitamin A compounds in rotifers and Artemia

Haga

Tarui

Ohta³

et al. 2006

Fisheries Sci

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The dynamics of vitamin A (VA) compounds in live food during enrichment were examined under different light conditions. Rotifers Brachionus plicatilis and Artemia nauplii (Artemia) were enriched with or without 10 mg VA palmitate (VAp) in 1 L of culture medium for 24 h under either bright (2000 lx), or dark (<1 lx) conditions. VAp, retinol (ROH), retinal (RAL) and retinoic acid (RA) contents were analyzed at 0 h (before enrichment) and at 3, 6, 12, 18 and 24 h after the onset of enrichment. Retinoid content in rotifers enriched in darkness was always higher than that enriched under light. VAp content showed two peaks at 3 and 18 h in rotifers enriched in darkness, but it showed one peak at 3 h in rotifers enriched under light. ROH and RA contents increased over the 24-h period in rotifers enriched in darkness, whereas they decreased 12 h onward in rotifers enriched under light. In Artemia, VAp and ROH contents were always higher than when enriched under the bright condition, but their dynamics showed a similar pattern in Artemia enriched under dark and bright conditions.

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“…The syndrome is known to be more frequent in females [11] and to affect mainly young women at the time of menarche [12], obese females with menstrual irregularities [13,14] and pregnant women [15,16]. The syndrome has also been described in association with a number of heterogeneous disorders, such as adrenal in sufficiency, hypoparathyroidism, corticosteroid hor mone withdrawal, lupus erythematosus, spinal cord tu mors, Guillain-Barre syndrome, intoxications with drugs or exogenous substances [4,5], In our cases there was no evidence of concomitant diseases, either of predisposing factors or exposure to noxious agents.…”

Section: Discussionmentioning

confidence: 99%

“…It is defined by four cri teria: (1) increased intracranial pressure; (2) papilledema and possibly secondary optic atrophy; (3) diminished or normal ventricular size on computed tomography (CT scan); (4) normal cerebrospinal fluid composition [1][2][3]. Although dural venous sinus thrombosis was noted to be a frequent cause of BIH, numerous other possible and unexplained conditions have been associated with it [4,5], In some patients, BIH has no detectable etiology, therefore it is defined as idiopathic. This paper reports the roughly simultaneous occurrence of pseudotumor cerebri in 2 male heterozygous twins as an isolated con dition.…”

Section: Introductionmentioning

confidence: 99%

Familial Pseudotumor cerebri in Male Heterozygous Twins

Torlai¹,

Galassi²,

Debbia³

et al. 1989

Eur Neurol

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Papilledema due to raised intracranial pressure in absence of intracranial mass arose roughly at the same time in 2 male heterozygous twins. The diagnosis of benign intracranial hypertension (BIH) was confirmed by the finding of normal cerebrospinal fluid and high opening pressure. Neurologic examination was normal. In both cases choroidal folds were evident. The relationship between BIH and genetic factors is discussed.

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Benign Intracranial Hypertension Associated With Hypervitaminosis A

Cited by 75 publications

References 79 publications

Idiopathic Intracranial Hypertension

Idiopathic Intracranial Hypertension

Effect of light irradiation on dynamics of vitamin A compounds in rotifers and Artemia

Familial Pseudotumor cerebri in Male Heterozygous Twins

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