Benign liver tumors in children: outcomes after resection

Qureshi, Sajid; Bhagat, Monica; Kembhavi, Seema; Vora, Tushar; Ramadwar, Mukta; Chinnaswamy, Girish; Prasad, Maya; Khanna, Nehal; Laskar, Sidharth

doi:10.1007/s00383-015-3763-3

Cited by 15 publications

(9 citation statements)

References 12 publications

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“…2,21 Haemangioma was the commonest benign liver tumor constituting 70% of all benign tumors in our series this is in comparison with other authors who have reported haemangioma constituting 72% of all the benign tumors in their series. 3 Most of the liver haemangiomas can be safely followed up.…”

Section: Discussioncontrasting

confidence: 41%

“…This is in comparison with Quresh SS et al, who reported that one third of their patients with benign liver tumors were managed with surgical excision, which comprised 11% of their re-sectional practice over a period of 10 years. 21 They have also reported that there was no mortality in their series and none of their patient had recurrence.…”

Section: Discussionmentioning

confidence: 96%

“…22,23 Both babies in our series had large tumors with both cystic and solid components affecting the right lobe of liver one of which is pedunculated. Both babies were treated by wide resection with healthy margins.…”

Section: Discussionmentioning

confidence: 99%

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Benign liver tumors in children-single centre experience

et al. 2017

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Background: To assess the incidence and management of benign liver tumors.Methods: Retrospective analysis of patients who were admitted with benign liver tumors in a Medical College Hospital in southern part of India during the period of 2006 to 2016 were analyzed.Results: We have treated a total of 10 cases of benign liver tumors during the period of 2006 to 2016. The mean age of presentation was 2.1 year. Seven of the ten cases were haemangiomas, two babies had mesenchymal hamartomas, one had focal nodular hyperplasia. Of the seven babies with haemangiomas, four had focal, two had diffuse involvement of liver, one baby had giant haemangioma. Three of the 4 babies with focal haemangiomas regressed during follow up, one baby lost follow up. One of the two babies with diffuse haemangioma developed high output cardiac failure but responded to digoxin, diuretics and steroids and now under follow up. The new born baby with giant haemangioma involving left lobe of liver also had high output heart failure which was refractory to medical therapy and required left lobectomy. Two babies had large mesenchymal hamartomas involving right lobe required surgical resection. One patient with focal nodular hyperplasia was managed conservatively. Mean follow up was 36 months. There were no deaths.Conclusions: Benign liver tumors are rare, most of them are haemangiomas. Only few of them require surgery. Large mesenchymal hamartomas can be promptly treated by resection with minimal mortality.

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Section: Discussioncontrasting

confidence: 41%

Section: Discussionmentioning

confidence: 96%

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Benign liver tumors in children-single centre experience

et al. 2017

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“…In our study, only 33% of patients with benign lesions were diagnosed by classic imaging criteria. Similarly, Qureshi et al reported that 38% of patients in their series were diagnosed as per radiological features [13]. In contradiction, Kochin et al declared that definitive diagnosis using imaging was achieved in 58.5% of the patients in their study [14].…”

Section: Discussionmentioning

confidence: 93%

Benign hepatic tumors in childhood: surgical resection and outcomes

et al. 2023

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Background Primary hepatic neoplasms in pediatric age are rare entities. Clinical and survival data in children with benign liver tumors who were treated by surgery are still negligible. We aimed to present a tertiary oncological center experience regarding surgical management and outcomes of pediatric benign hepatic tumors. Material and methods A retrospective chart review was performed including all children with benign liver tumors who were surgically managed at our institution from January 2014 to January 2022. Patients’ demographics, presentations, imaging scans, pathological subtypes, operative details, complications that happened, and overall outcomes were discussed. Results One-hundred ninety-three children with liver tumors were referred to our center, and 28 of them had benign tumors (14.5%). Ten patients were managed by medical therapy (all were IHH/hemangiomas), and the remaining 18 were treated by surgery. Of the 18 patients; there were 10 females (55.5%), and the median age at diagnosis was 24 months (range: 5–108 months). Palpable abdominal mass was the main symptom in 14 patients (77.8%). Eleven patients (61%) were PRETEXT II, while the remaining 7 (39%) were PRETEXT I. The median tumor size was 10.9 cm (range: 7.2–18 cm). Preoperative biopsy was conducted in 12 patients (66.7%). Seventeen patients had primary resection, while the remaining child with IHH/hemangioma underwent delayed surgery. Twelve cases had segmental resection or sectionectomy, and hemihepatectomy was performed in the remaining six. The resection rate of benign tumors versus all liver resections at our center during the study period was 12% (18/151). There were no intraoperative complications encountered in any patient. Only one patient developed biliary leakage on the 5th postoperative day which was managed conservatively. At a median follow-up time of 40 months, there were no deaths or recurrences among the included patients. Conclusions Surgical resection is the principal modality of management for the majority of pediatric benign liver tumors, which constituted 12% of our hepatic resection rate. Complete excision with negative margins can be performed without significant morbidity for such tumors, and it achieves excellent clinical and long-term oncological outcomes.

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“…Karaciğerin benign tümörlerinin cerrahi tedavilerinde anatomik olmayan rezeksiyonun emniyetli bir şekilde yapılabileceği belirtilmiştir (23) . Ancak art arda yapı-lan iki Alman çalışmasında, atipik rezeksiyon yapılan hepatoblastomlu olguların %38'inde rezeksiyon sonrası tümör kaldığı, sonuçların bu hastalarda en kötü olduğu görülmüştür.…”

Section: Rezeksiyonunclassified