Benign lymphoepithelial lesion in a patient with Sjögren's disease and an IgG paraprotein

Abstract

Clinical and laboratory investigations were performed on a patient presenting with xerostomia and swelling of the parotid gland. Lymphoid infiltration of the salivary glands (parotid and labial) and paraproteinaemia were found. Immunoperoxidase studies of labial and parotid glands revealed that local immunoglobulin synthesis was essentially polyclonal although monoclonal staining of Russell bodies within the labial tissue suggested that at least some of the serum paraprotein was being synthesised locally. The implications of these findings are discussed in terms of diagnosis and treatment.

Effects of Cevimeline on the Immunolocalization of Aquaporin-5 and the Ultrastructure of Salivary Glands in Sjögren’s Syndrome Model Mice

“…Histologically, SS is characterized by extensive lymphocyte infiltration around blood vessels [21]. In the present study, we used MRL/l mice, which were originally obtained by hybridization of AKR/J, C57BL/6J, C3H/Di and…”

Salivary gland expression of transforming growth factor beta isoforms in Sjogren's syndrome and benign lymphoepithelial lesions

“…This last patient had SS and was known to have had an IgG paraprotein at the time of diagnosis. 30 For control purposes, five paraffin wax blocks of parotid gland that had been reported as showing normal histology were also retrieved from the pathology files (mean age, 50.2 years). These glands had been excised because of recurrent swelling.…”