Benign monoclonal expansion of CD8+ lymphocytes in HIV infection

Smith, Penelope

doi:10.1136/jcp.53.3.177

Cited by 68 publications

(52 citation statements)

References 22 publications

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“…The clonal expansions can be large and may persist with dominance of specific clones. [31][32][33][34] In summary, our results show that monoclonal expansion of T-cell population occurs frequently in B-cell post-transplant lymphoproliferative disorders and these clonal T-cell populations coexist with monoclonal B-cell population in B-cell posttransplant lymphoproliferative disorders. The T-cell clones seem to arise mainly from CD8-positive T cells.…”

Section: Discussionmentioning

confidence: 92%

Presence of monoclonal T-cell populations in B-cell post-transplant lymphoproliferative disorders

et al. 2011

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As has been previously shown, the lack of immune surveillance plays a major role in the unchecked proliferation of Epstein-Barr virus (EBV)-infected B cells in the pathogenesis of B-cell post-transplant lymphoproliferative disorders. We hypothesised that the lack of immune surveillance should possibly also affect T cells, and this should lead to subsequent emergence of T-cell clones. The presence of both B-and T-cell clones in post-transplant lymphoproliferative disorders samples has rarely been demonstrated in the past. We systematically evaluated 26 B-cell post-transplant lymphoproliferative disorder, 23 human immune deficiency virus-associated B-cell lymphoma and 10 immune-competent diffuse large B-cell lymphoma samples for B-and T-cell clonality (polymerase chain reaction and heteroduplex analysis using BIOMED-2 protocol), T-cell subsets (immunohistochemistry) and EBV association (in situ hybridisation using EBER). One-half of B-cell posttransplant lymphoproliferative disorders showed evidence of monoclonal T-cell expansion, and among the T cells present in the tissue samples, CD8-positive cells predominated. Although 9/13 (69%) B-cell posttransplant lymphoproliferative disorders with the presence of monoclonal T-cell population had a CD4:CD8 ratio of r0.4, 0/13 of the cases without monoclonal T-cell expansion had a ratio r0.4 (P ¼ 0.002). Only 2/26 (8%) demonstrated significant cytological atypia in the CD3/CD8-positive cells. There was no association between EBV and presence of T-cell clones. T-cell clones were not identified in lymphomas other than B-cell post-transplant lymphoproliferative disorders. Among 53.8% cases of EBV-positive B-cell post-transplant lymphoproliferative disorders with associated clonal expansion of T-cells tested, none had EBV-positive T cells. We conclude that half of B-cell post-transplant lymphoproliferative disorders are associated with clonal expansion of CD8-positive T cells, most of which do not amount to the coexistence of a T-cell post-transplant lymphoproliferative disorders.

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Section: Discussionmentioning

confidence: 92%

Presence of monoclonal T-cell populations in B-cell post-transplant lymphoproliferative disorders

et al. 2011

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“…However, not all expansions of LGLs are malignant, and benign LGL proliferations are seen in several clinical conditions (Table 3), including patients with HIV infections [19], postsplenectomy patients [20], and in patients after allogeneic bone marrow transplantation [21] or solid organ transplantation [22].…”

Section: Diagnosismentioning

confidence: 99%

T-Cell Large Granular Lymphocyte Leukemia and Related Disorders

2004

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“…[27][28][29] Clonal expansions of cytotoxic cells have also been observed in the context of hematologic malignancies, such as multiple myeloma, 30 myelodysplastic syndrome, 31 and acute promyelocytic leukemia, 32 and have been linked to cancer immune surveillance. Small numbers of clonal and persistent CD4 ϩ and CD8 ϩ cells have been shown to exist in healthy persons and become more common with advanced age.…”

Section: Introductionmentioning

confidence: 99%

Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy

Kreutzman

Juvonen

Kairisto

et al. 2010

Blood

161

142

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In a proportion of patients with chronic myeloid leukemia (CML) being treated with dasatinib, we recently observed large granular lymphocyte (LGL) expansions carrying clonal T-cell receptor (TCR) ␥/␦ gene rearrangements. To assess the prevalence and role of clonal lymphocytes in CML, we collected samples from patients (n ‫؍‬ 34) at the time of diagnosis and during imatinib and dasatinib therapies and analyzed lymphocyte clonality with a sensitive polymerase chain reaction-based method of TCR ␥ and ␦ genes. Surprisingly, at CML diagnosis, 15 of 18 patients (83%) had a sizeable clonal, BCR-ABL1 negative lymphocyte population, which was uncommon in healthy persons (1 of 12; 8%). The same clone persisted at low levels in most imatinibtreated patients. In contrast, in a distinct population of dasatinib-treated patients, the diagnostic phase clone markedly expanded, resulting in absolute lymphocytosis in blood. Most patients with LGL expansions (90%) had TCR ␦ rearrangements, which were uncommon in patients without an LGL expansion (

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Benign monoclonal expansion of CD8+ lymphocytes in HIV infection

Cited by 68 publications

References 22 publications

Presence of monoclonal T-cell populations in B-cell post-transplant lymphoproliferative disorders

Presence of monoclonal T-cell populations in B-cell post-transplant lymphoproliferative disorders

T-Cell Large Granular Lymphocyte Leukemia and Related Disorders

Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy

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