Benign Müllerian Papilloma of Childhood

Abstract

Benign müllerian papilloma of the female reproductive tract is a rare childhood tumor that can easily be mistaken by those unfamiliar with the entity for botryoid rhabdomyosarcoma. Ultrastructural findings have been mentioned only in two individual case reports, and these both were issued many years ago. The aim of this update is to familiarize the reader with the clinical, light, and electron microscopic features associated with this distinctive entity, and thereby hopefully preclude the risk of making a serious diagnostic error. Two cases are illustrated, one very typical in its presentation and the other less so.

Vaginal Müllerian Papilloma: An Unusual Cause of Vaginal Bleeding in a Toddler

“…It usually presents as noncyclical vaginal bleeding in children less than 5 years of age. 2,3 The pathologic characteristics are also unique for this entity, although its exact identifying terminology has gone through changes through time. 3 Müllerian papillomas are benign, well-differentiated tumors that carry a good prognosis even with recurrence.…”

“…2,3 The pathologic characteristics are also unique for this entity, although its exact identifying terminology has gone through changes through time. 3 Müllerian papillomas are benign, well-differentiated tumors that carry a good prognosis even with recurrence. 4 They are usually located on the cervix but can be located anywhere in the female genital tract.…”

Genital Sanguineous Discharge in Prepuberty: A Case of Mullerian Papilloma of Vagina in a 9 Year-Old Girl

“…This benign neoplasm occurs most frequently in prepubertal girls and its clinical sign is intermittent, non cyclic vaginal bleeding 5,6 . Morphologically it appears as a grape-like or papillary mass 6 .…”

“…Morphologically it appears as a grape-like or papillary mass 6 . Only 40 cases have been reported; 26 of them have been described in children.…”