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The ultrastructure of three cases of osteoblastoma is described. The osteoblasts resemble normal osteoblasts with a few exceptions: irregular, indented nuclei, and occasional mitochondria with curved cristae and electron-lucent areas. The osteocytes and osteoclasts basically resemble their normal counterparts. There are also osteoprogenitor cells in different stages of maturation, some containing glycogen. The ultrastructure of a n additional case histologically classified as aggressive osteoblastoma is described. It is essentially similar to the previous three cases of typical osteoblastoma. The only exception is the presence of osteoblasts with electron-lucent nuclei and less prominent organelles than the typical osteoblastoma cells. A case of osteosarcoma is studied for comparison. The osteosarcoma cells have markedly indented and multilobed nuclei, dilated rough endoplasmic reticulum and lipid droplets. However, these differences from osteoblastoma cells are not pathognomonic. The final diagnosis of osteoblastic tumors rests at the light microscopy level.Cancer 39:2127-2136, 1977.STEOBLASTOMA IS AN UNCOMMON RONE-0 forming tumor, originally described by ,Jaffe and Meyer17 in 1932. It is characterized histologically by a highly vascular matrix, rich in osteoblasts, with osteoid and bone formation. s, la'' The term "benign osteoblastoma" was proposed for this tumor by Jaffe16 and Lichtenstein" working independently in 1956. This term is now generally accepted. Osteoblastoma occurs most frequently in young individuals and predilects the vertebral column and long There is only one report in the literature concerning the ultrastructure of osteoblastoma. " In this paper a detailed account of the ultrastructure of three cases of typical osteoblastoma is presented. A fourth case classified histologically as aggressive osteoblastoma" is also included in this presentation. In addition, a case of osteosarcoma is studied for comparison with the osteoblastomas. ried out using 3% glutaraldehyde followed by postfixation' in 1% osmium tetroxide, both in sodium cacodylate buffer. The tissue was then dehydrated and embedded in Epon 812. In order to prevent demineralization of the tissue during sectioning, the method described by Boothroyd4 was carefully followed CASE REPORTSThree patients with histologically proven typical osteoblastoma (Fig. 1) were examined. All lesions were larger than 2 cm. The pertinent data of these cases is included in Table 1. OsteoblastsThe osteoblasts varied in shapeand size. They were generally ovoid and elongated. The nuclei were usually eccentric with irregular, indented nuclear membrane and the chromatin was condensed toward the periphery (Figs. 2 and 3).The rough endoplasmic reticulum was abundant and frequently dilated (Fig. 3). T h e Golgi apparatus was well developed and juxtanuclear, and often contained dilated polyhedral vesicles (Fig. 3). The mitochondria were round and ovoid with transverse cristae and occasional intramitochondrial granules. Some mitochondria were elongated with cristae...
The ultrastructure of three cases of osteoblastoma is described. The osteoblasts resemble normal osteoblasts with a few exceptions: irregular, indented nuclei, and occasional mitochondria with curved cristae and electron-lucent areas. The osteocytes and osteoclasts basically resemble their normal counterparts. There are also osteoprogenitor cells in different stages of maturation, some containing glycogen. The ultrastructure of a n additional case histologically classified as aggressive osteoblastoma is described. It is essentially similar to the previous three cases of typical osteoblastoma. The only exception is the presence of osteoblasts with electron-lucent nuclei and less prominent organelles than the typical osteoblastoma cells. A case of osteosarcoma is studied for comparison. The osteosarcoma cells have markedly indented and multilobed nuclei, dilated rough endoplasmic reticulum and lipid droplets. However, these differences from osteoblastoma cells are not pathognomonic. The final diagnosis of osteoblastic tumors rests at the light microscopy level.Cancer 39:2127-2136, 1977.STEOBLASTOMA IS AN UNCOMMON RONE-0 forming tumor, originally described by ,Jaffe and Meyer17 in 1932. It is characterized histologically by a highly vascular matrix, rich in osteoblasts, with osteoid and bone formation. s, la'' The term "benign osteoblastoma" was proposed for this tumor by Jaffe16 and Lichtenstein" working independently in 1956. This term is now generally accepted. Osteoblastoma occurs most frequently in young individuals and predilects the vertebral column and long There is only one report in the literature concerning the ultrastructure of osteoblastoma. " In this paper a detailed account of the ultrastructure of three cases of typical osteoblastoma is presented. A fourth case classified histologically as aggressive osteoblastoma" is also included in this presentation. In addition, a case of osteosarcoma is studied for comparison with the osteoblastomas. ried out using 3% glutaraldehyde followed by postfixation' in 1% osmium tetroxide, both in sodium cacodylate buffer. The tissue was then dehydrated and embedded in Epon 812. In order to prevent demineralization of the tissue during sectioning, the method described by Boothroyd4 was carefully followed CASE REPORTSThree patients with histologically proven typical osteoblastoma (Fig. 1) were examined. All lesions were larger than 2 cm. The pertinent data of these cases is included in Table 1. OsteoblastsThe osteoblasts varied in shapeand size. They were generally ovoid and elongated. The nuclei were usually eccentric with irregular, indented nuclear membrane and the chromatin was condensed toward the periphery (Figs. 2 and 3).The rough endoplasmic reticulum was abundant and frequently dilated (Fig. 3). T h e Golgi apparatus was well developed and juxtanuclear, and often contained dilated polyhedral vesicles (Fig. 3). The mitochondria were round and ovoid with transverse cristae and occasional intramitochondrial granules. Some mitochondria were elongated with cristae...
In a review of more than 1000 patients with osteogenic sarcoma of bone, the vertebral column was the site of the primary tumor in 10 patients. The vertebral osteogenic sarcoma in 4 of the 10 patients was secondary; to Paget's disease of bone in 3, and to irradiation received for a prior cancer in 1. Frequently, cord compression caused severe neurologic symptoms. Prognosis was always poor. Seven patients died of their disease within a year of histologic diagnosis. The differential diagnoses between osteogenic sarcoma and three benign tumors are reviewed, osteoblastoma being the tumor most frequently confused with osteogenic sarcoma. The radiologic and histologic criteria for distinguishing between the two are discussed.
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