Newton et al Case: Antenatal US diagnosis of a giant penile inclusion cyst2 © 2023 Canadian Urological Association cystic structure at the distal, dorsal aspect of the foreskin just left of midline (Fig 1c). The foreskin was easily reducible. The meatus was orthotopic, and both testes were normally descended. Ultrasound revealed a mildly complex cystic structure at the tip of the penis with a difficult to visualize distal urethra (Fig 1d).After counseling, the family elected to proceed with observation. By history, the mass continued to enlarge before rupturing spontaneously at one month of age. The parents reported drainage of white fluid from the cyst. At 2 month follow-up, spontaneous rupture was confirmed, and the family elected to proceed with elective circumcision.At nine months of age, cyst excision and phalloplasty were performed. Upon initial dissection, the cyst was pedunculated (Fig 2b). The cyst and stalk were external to the corpora and urethra. Although the cyst was dorsal, the stalk appeared to connect to the urethra ventrally. It was excised and sent for pathologic analysis. A leak test was performed without evidence of communication between the stalk and the urethra. Retraction of the foreskin revealed 90-degree counterclockwise penile torsion. This was fully identified after the penis was degloved due to mass effect from the cystic structure (Fig 2c). On further evaluation, torsion was noted to be due to rotation of the left corporal body posterior to the spongiosum. The dartos fascia was fixed to the corporal bodies at the penoscrotal junction to correct the torsion and penile concealment. Subsequently, the dorsal foreskin was incised to the level of the mucosal collar, and the preputial flaps were rotated ventrally and approximated at the midline to recreate the median raphe. Finally, the skin was anastomosed to the mucosal collar to complete the phalloplasty (Fig 2d).At his six-week postoperative visit, incision sites were healing well with no evidence of recurrence, and he was voiding without issue (Fig 3). Final pathology demonstrated squamous epithelial lining and chronic inflammatory changes consistent with an inclusion cyst. The stalk contained urothelial lining. All specimens were benign (Fig 4).
DISCUSSIONPenile cysts are uncommon genitourinary malformations that are often not detected until adolescence or adulthood and are hence acquired rather than congenital. 3 Such cysts are typically located on the ventral midline of the penis. Acquired (or false) cysts include preputial Epstein pearls, trichilemmal cysts, epidermal inclusion cysts, and smegma cysts. 4 Smegma cysts, or 'smegmomas', are the most common penile cystic lesion. They form due to an accumulation of smegma beneath an unretractable foreskin and are often yellow in color. 5 While smegma cysts typically occur secondary to physiologic adhesions present at birth, epidermal inclusions cysts typically form following penile surgeries, including circumcision and hypospadias repair. Epidermal inclusion cysts may also be congenital ...