Purpose
We prospectively evaluated the association between adiposity and risk of lower urinary tract symptoms (LUTS) incidence and progression in the Health Professionals Follow-up Study (HPFS).
Materials and Methods
Participants reported their current height and weight and their weight at age 21 at baseline, a year later their waist and hip circumferences, and then every two years their weight. Periodically, participants completed the International Prostate Symptom Score (IPSS) survey and reported surgery or medication use for LUTS. We used Cox proportional hazards regression to estimate the multivariable-adjusted association between adiposity and LUTS incidence and progression. The incidence analytic cohort (n=18,055) were men without LUTS at baseline. Men entered the progression analytic cohort (n=6,461) when they first experienced LUTS.
Results
Risk of LUTS (n=4,088) increased with increasing body mass index (BMI ≥35 vs 23-<25 kg/m2: HR=1.61; 95% CI 1.31–1.99, p-trend<0.0001), waist circumference (>42 vs ≤33 in: HR=1.39, 95% CI 1.19–1.63, p-trend<0.0001), and weight gain from age 21 (≥50 lbs vs stable weight: HR=1.31, 95% CI 1.17–1.46, p-trend=<0.0001). Risk of LUTS progression (n=1,691) increased with BMI (≥35 vs 23-<25 kg/m2: HR=1.44, 95% CI 1.04–2.00, p-trend=<0.0001), weight gain from 21 years of age (≥50 lbs vs stable weight: HR=1.35, 95% CI 1.14–1.60, p-trend=<0.0001), and waist circumference (>42 vs ≤33 in: HR=1.32, 95% CI 0.95–1.85, p-trend=0.005).
Conclusions
Men with higher total and abdominal adiposity or who gained weight were more likely to develop LUTS or experience progressive LUTS. Our findings support that obesity may be an important target for LUTS prevention and intervention.