Benign Prostatic Hyperplasia—Video Image Analysis and its Relationship to Androgen and Epidermal Growth Factor Receptor Expression

Frydenberg, Mark; Foo, T.M.S.; Jones, Allan S.; Grace, Julienne; Hensley, W.J.; Rogers, John G.; Pearson, B; Raghavan, Derek

doi:10.1016/s0022-5347(17)37951-x

Cited by 22 publications

(15 citation statements)

References 29 publications

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“…24 Obesity has effects on many hormones, including an increase of estrogen and decrease of testosterone levels, 1 due to aromatization of androgens to estrogens in the adipose tissue. 25 Androgens are involved in the development and maintenance of BPH, as supported by androgen receptor expression in prostate epithelium, 26,27 and by the observation of high testosterone levels in men with prostate cancer in several, although not all studies. 28 Androgen receptor gene polymorphisms (and particularly a CAG repeat length of o21 and a CGN repeat length o16) was also associated with the risk of BPH in a study from Olmsted County, MN, USA.…”

Section: Discussionmentioning

confidence: 99%

History of weight and obesity through life and risk of benign prostatic hyperplasia

et al. 2005

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OBJECTIVE:The relation of anthropometric measures, diabetes, hypertension and hyperlipidemia with benign prostatic hyperplasia (BPH) risk was investigated. DESIGN: Hospital-based case-control study. SUBJECTS: Cases were 1369 men with histologically confirmed BPH, and controls were 1451 men below 75 y, admitted to hospital for acute non-neoplastic diseases. MEASUREMENTS: Using a structured questionnaire, trained interviewers collected information on self-reported height and weight, and measured waist and hip circumference of patients. The odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional multiple logistic regression models. RESULTS: Compared to the corresponding lowest quartile, the OR for the highest one were 0.76 (95% CI 0.59-0.98) for body weight, 0.71 (95% CI 0.54-0.94) for waist-to-hip ratio and 0.87 (95% CI 0.70-1.09) for body mass index (BMI, kg/m 2 ). Compared to a lowest lifelong BMI o20.7 kg/m 2 , the OR was 1.56 (95% CI 1.25-1.95) for a lowest lifelong BMI Z23.7 kg/m 2 . The OR was 0.74 (95% CI 0.60-0.93) for a lifelong increase of BMI Z6.1 kg/m 2 , compared to o1.6 kg/m 2 . No association emerged for history of diabetes, hypertension and hyperlipidemia. CONCLUSIONS: Overweight was modestly, inversely related to BPH. The hypothesis of reduced testosterone levels in obese individuals may explain the different BPH risk and need to be tested.

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Section: Discussionmentioning

confidence: 99%

History of weight and obesity through life and risk of benign prostatic hyperplasia

et al. 2005

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“…Smoking/ tobacco chewing may act by increasing inflammation in prostatic tissue, so that smokers are more prone to prostatic diseases in- cluding BPH or prostate cancer, than in nonsmokers. Androgens play a role in the development and maintenance of BPH particularly in the prostatic epithelium, which is supported by androgen receptor expression in prostatic epithelium [27]. Alcohol consumption is suggested to decrease testosterone concentrations and in some cases increase estrogens concentration hence higher susceptibility to BPH [28].…”

Section: Discussionmentioning

confidence: 99%

GSTM1,GSTM3andGSTT1Gene Variants and Risk of Benign Prostate Hyperplasia in North India

et al. 2009

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Abstract. Glutathione S-transferases (GSTs) play an important role in detoxification of various toxic compounds like carcinogens in cigarette smoke and tobacco by conjugating to toxic compounds and inactivating their hazardous effect. Variation in Glutathione S-Transferases (GSTs) genes may alter the catalytic efficiency of GST isoenzymes leading to potential increase in cancer susceptibility due to various carcinogens. We therefore, investigated association of GSTM1, GSTM3 and GSTT1 variants with susceptibility to benign prostate hyperplasia (BPH) and cigarette, tobacco chewing and alcohol consumption as confounding factors in 141 BPH and 184 healthy controls. Results showed increased risk for BPH susceptibility in patients with GSTM1 null genotype (OR-2.03, p = 0.013) and smoking (OR-3.12, p = 0.028), tobacco chewing (OR-2.54, p = 0.039) and alcohol habits (OR-3.39, p = 0.010). Null genotype of GSTM1 with cigarette, tobacco and alcohol habits predisposed increased risk for BPH.

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“…Morphometric image analysis has also been used to help determine the expression of the receptors for epithelial growth factors in benign prostatic hyperplasia (25), besides contributing for the study of the metabolism of satellite hyperplasic epithelial cells affected by growth factors produced by cancerous prostatic cells (26). However, it is fundamental in morphometric studies of the nuclei of prostatic epithelial cells, that there is an initial immediate fixation of the material (27), as it occurred in the present study.…”

Section: Commentsmentioning

confidence: 99%

Bladder drainage and glandular epithelial morphometry of the prostate in benign prostatic hyperplasia with severe symptoms

2006

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Objective: Morphometrically analyze the cells nuclei of the basal layer of the prostatic glandular epithelium in 20 patients aged between 57 and 85 years presenting benign prostatic hyperplasia with severe symptoms, catheterized or not. Materials and Methods:Patients with score of severe prostatic symptoms (with indication for transurethral resection of the prostate) were distributed according to the presence or absence of bladder drainage previous to the surgery, in the treated group (n = 10, catheter during 3 months) and in the control group (n = 10, without catheter). After obtaining prostate fragments through transurethral resection and the use of morphometric techniques, 100 nuclei of prostatic glands epithelium cells were studied (as to size and form), and compared to 500 nuclei from patients submitted to catheter drainage and 500 nuclei of non-catheterized patients. Results:Significantly reduced values of the major, medium and minor nuclear diameters, volume, area and perimeter, contour index and nuclear volume-nuclear area ratio were observed in the treated group in relation to the control group. As to the form, eccentricity and coefficient of nuclear form, there were significant differences between treated and control groups. Conclusion: Long-term catheter bladder drainage in patients presenting benign prostatic hyperplasia with severe symptoms is associated to the reduction of morphometric parameters of the nuclei of prostatic glands' epithelial cells, suggesting a likely decompressive duct effect.

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Benign Prostatic Hyperplasia—Video Image Analysis and its Relationship to Androgen and Epidermal Growth Factor Receptor Expression

Cited by 22 publications

References 29 publications

History of weight and obesity through life and risk of benign prostatic hyperplasia

History of weight and obesity through life and risk of benign prostatic hyperplasia

GSTM1,GSTM3andGSTT1Gene Variants and Risk of Benign Prostate Hyperplasia in North India

Bladder drainage and glandular epithelial morphometry of the prostate in benign prostatic hyperplasia with severe symptoms

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