Benign recurrent intrahepatic cholestasis

Gupta, Viney; Kumar, Mohit; Bd, Bhatia

doi:10.1007/bf02734154

Cited by 11 publications

(7 citation statements)

References 8 publications

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“…Approximately 100 cases of BRIC have been reported till date. [11,12,13] In a case of a 47 year old female with psoriasis with history of methotrexate intake with a high cumulative dose since 2 years. Liver biopsy was done which showed hepatocytes with mild ballooning degeneration, mild macrovesicular steatosis and mild periportal fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Changing Role of Liver Biopsy Indications in A Tertiary Care Centre

Kalaranjini

Glaxon

Vasudevan

2019

APALM

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Background:The histomorphological study of liver biopsy is the best means to ascertain the nature and signifi¬cance of pathological processes occurring in the liver. The current non-invasive tools are unqualified to replace liver biopsy in clinical practice.Methods: This is a one year prospective study from January 2017 to 2018. A total of twenty five cases suspected to have chronic parenchymal liver disease, inflammatory lesions or neoplastic lesions were included in the study. Detailed history and investigations done including biochemical parameters, radiological and other investigative procedures done were recorded and percutaneous liver biopsy was done using trucut needle.Results: Out of the total 25 liver biopsy done, 60% cases were male, 40% were females. Majority of the patients belonged to the sixth decade (32%). Youngest patient was a 12 year boy with history of intermittent jaundice since birth, and the oldest patient was a 78 year old male. The most prevalent pathological diagnosis was cirrhosis with steatohepatitis with 7 cases (28%), followed by Non Alcoholic Fatty Liver Disease (NAFLD) and autoimmune hepatitis, 12% each. Conclusion:Liver biopsy is the gold standard for diagnosis of chronic liver diseases and plays a valuable role in diagnosis, prognostic and management of liver diseases.

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Section: Discussionmentioning

confidence: 99%

Changing Role of Liver Biopsy Indications in A Tertiary Care Centre

Kalaranjini

Glaxon

Vasudevan

2019

APALM

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“…The transaminases are usually in normal range but can increase up to 200-400 U/L [4]. The disease follows a benign course and there is no progression to cirrhosis [5]. However, a case report has revealed that some patients initially presenting with clinical features of BRIC may later progress to progressive familial intrahepatic cholestasis.…”

Section: Discussionmentioning

confidence: 99%

Benign recurrent intrahepatic cholestasis associated with pregnancy

Aggarwal¹,

Jain²,

Gupta³

et al. 2012

CMJ

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Benign recurrent intrahepatic cholestasis is a rare condition which is believed to be an autosomal recessive disorder characterized by mutation in the aminophospholipid flippase gene ATP8B1 located on chromosome 18q21. It is characterized by recurrent episodes of intrahepatic cholestasis with normal gamma glutamyl transferase. We here describe a case of benign intrahepatic cholestasis associated with pregnancy.

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“…These signs may persist or recur throughout life but do not lead to chronic liver disease or cirrhosis [2,3]. The treatment of BRIC is purely symptomatic.…”

Section: Discussionmentioning

confidence: 99%

“…The treatment of BRIC is purely symptomatic. There are conflicting reports regarding the effect of therapeutic alternatives such as UDCA, cholestyramin and rifampicin [3][4][5]. CTS is also rare in childhood.…”

Section: Discussionmentioning

confidence: 99%

A rare cause of carpal tunnel syndrome in childhood: Benign recurrent intrahepatic cholestasis

et al. 2010

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AbstractCarpal tunnel syndrome and benign recurrent intrahepatic cholestasis are rare conditions in childhood. Benign intrahepatic cholestasis is characterized by repeated self-limited attacks of cholestasis that can start at any age and last from weeks to months. The patients are asymptomatic between these attacks. We report a 16 year-old male patient with benign recurrent intrahepatic cholestasis who developed carpal tunnel syndrome during a cholestatic attack. He was admitted with complaints of jaundice, pruritus and pain, tingling and muscle weakness in both hands for 15 days. Nerve conduction studies revealed findings compatible with carpal tunnel syndrome. He was started on ursodeoxycholic acid, fat soluble vitamins and cholestyramine and cholestasis regressed after four weeks of therapy. With the improvement of cholestasis, the symptoms of carpal tunnel syndrome also disappeared. In conclusion, benign recurrent intrahepatic cholestasis can be a rare cause of carpal tunnel syndrome in childhood. We also advocate treating the underlying disease as an appropriate conservative treatment before surgery.

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Benign recurrent intrahepatic cholestasis

Cited by 11 publications

References 8 publications

Changing Role of Liver Biopsy Indications in A Tertiary Care Centre

Changing Role of Liver Biopsy Indications in A Tertiary Care Centre

Benign recurrent intrahepatic cholestasis associated with pregnancy

A rare cause of carpal tunnel syndrome in childhood: Benign recurrent intrahepatic cholestasis

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