Benign Recurrent Pleomorphic Adenoma of the Parotid Gland with Perineural Space Invasion

Roncati, Luca; Maiorana, Antonio

doi:10.4068/cmj.2017.53.3.236

Cited by 1 publication

(1 citation statement)

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“…Selesnik and Burt described five head and neck malignant neoplasms and one benign parotid gland adenoma demonstrating PNI [133]. Roncati and Maiorana described a case of a 30-year-old woman with a recurrent pleomorphic adenoma of the parotid gland with PNI [134]. A report by our group also described a case of a 73-yearold woman with a left parotid gland mass, which-upon examination-was diagnosed as a sclerosing polycystic adenoma with evidence of perineural entrapment [135] (Figure 4).…”

Section: Adenomas Of the Parotid Glandmentioning

confidence: 99%

Unraveling the Mysteries of Perineural Invasion in Benign and Malignant Conditions

Bahmad,

Gogola,

Rejzer

et al. 2023

Current Oncology

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Perineural invasion (PNI) is defined as the dissemination of neoplastic cells within the perineural space. PNI can be a strong indicator of malignancy and is linked to poor prognosis and adverse outcomes in various malignant neoplasms; nevertheless, it can also be seen in benign pathologic conditions. In this review article, we discuss various signaling pathways and neurotrophic factors implicated in the development and progression of PNI. We also describe the methodology, benefits, and limitations of different in vitro, ex vivo, and in vivo models of PNI. The spectrum of presentation for PNI can range from diffuse spread within large nerves (“named” nerves) all the way through localized spread into unnamed microscopic nerves. Therefore, the clinical significance of PNI is related to its extent rather than its mere presence or absence. In this article, we discuss the guidelines for the identification and quantification of PNI in different malignant neoplasms based on the College of American Pathologists (CAP) and World Health Organization (WHO) recommendations. We also describe benign pathologic conditions and neoplasms demonstrating PNI and potential mimics of PNI. Finally, we explore avenues for the future development of targeted therapy options via modulation of signaling pathways involved in PNI.

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Section: Adenomas Of the Parotid Glandmentioning

confidence: 99%