Benign urethral villous adenoma. Case report

Howells, M. R.; Baylis, M. S.; Howell, S.

doi:10.1111/j.1471-0528.1985.tb03007.x

Cited by 6 publications

(4 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The former splits into three sections: presumptive bladder, pelvic urethra, and presumptive definitive urogenital sinus, which becomes the vaginal vestibule, and the glandular remnant in the bladder or urethra may give rise to these villous tumors. Based on this pathogenic hypothesis, villous adenomas in the bladder, urethra, and vaginal vestibule have been reported[9]. There is another assumption that these lesions originate from injured urothelial stem cells due to long-term irritation, such as chronic infection and chemical injury, which result in glandular metaplasia[1,2,19,20].…”

Section: Discussionmentioning

confidence: 99%

Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature

Qin¹,

Liang²,

Xing³

et al. 2019

WJCC

View full text Add to dashboard Cite

BACKGROUND Villous adenomas of the urinary tract are uncommon. They are morphologically similar to and difficult to differentiate from their counterpart in the colon. The histogenesis and malignant potential are uncertain. CASE SUMMARY A 63-year-old woman was admitted to our hospital with a mass in the urethral orifice. Gross and microscopic pathological examination was suggestive of urethral villous adenoma with focal well-differentiated adenocarcinoma. The whole urethra and part of the bladder were excised. No further treatment was offered. Carcinoembryonic antigen, cytokeratin 7, cytokeratin 20, epithelial membrane antigen, and p53 protein were positive, and the ratio of Ki-67 was 60%. After follow-up at 11 mo, the patient was cured and had no recurrence. CONCLUSION Immunohistochemistry is important for differential diagnosis of villous adenoma of the urinary system. Complete surgical resection of the urinary tract is curative.

show abstract

Section: Discussionmentioning

confidence: 99%

Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature

Qin¹,

Liang²,

Xing³

et al. 2019

WJCC

View full text Add to dashboard Cite

show abstract

“…The latter gives rise to the bladder, pelvic urethra and definitive urogenital sinus, which becomes the vaginal vestibule 10, 12, 13. Interestingly, according to this etiological hypothesis, villous adenomas have been described in the bladder and the urethra and in the vaginal vestibule 5. Several authors have also postulated that these lesions could arise from paraurethral Skene glands, which are usually immunoreactive for PSA 14.…”

Section: Discussionmentioning

confidence: 99%

“…Villous adenoma of the urinary tract is a rare tumor, histologically close to colonic villous adenoma, which is encountered in the bladder, urachus, ureter and prostatic urethra 1–3. This tumor exceptionally affects the female urethra and only isolated case reports have been described with a coexistent adenocarcinoma (Table I) 1, 4–7. To the best of our knowledge, this is the first case to be described of villous adenoma of the vulvar urethra associated with concomitant adenosquamous carcinoma.…”

Section: Introductionmentioning

confidence: 87%

Adenosquamous carcinoma arising in villous adenoma from female vulvar urethra

Noël¹,

Fayt²,

Aguilar³

2006

Acta Obstet Gynecol Scand

View full text Add to dashboard Cite

“…Male predominance has been reported (1,2,5). VAs of the female urethra are very rare with only seven cases in the English literature to our knowledge (Table I) (1,(6)(7)(8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 91%

Villous adenoma arising in the urethra of a female with bladder augmentation history: a case report and review of the literature

Demir

Cin²,

Çitgez³

et al. 2020

TJPATH

View full text Add to dashboard Cite

Villous adenomas (VAs) in the female urethra are rare with only seven cases in the English literature to our knowledge. In patients with bladder augmentation cystoplasty, the neoplasia development risk increases and most of these develop in the neobladder or anastomosis line. Only two cases of VA developing from the native bladder mucosa have been reported. Physical examination of a 76-year-old female who had a history of augmentation cystoplasty revealed a caruncula-like structure protruding from the urethral meatus. The urinary USG showed that the lesion had no relation with the bladder. The lesion was excised. Microscopically, it consisted of villous structures covered with pseudostratified intestinal type epithelium. Low-grade dysplasia was present in the epithelium but high-grade dysplasia or in-situ/invasive carcinoma was not observed. Immunohistochemical study showed positivity for CK7, CK20, EMA, CEA and CDX2. The case was reported as VA of the urethra. We presented the first VA case arising in the urethra of a female patient with intestinal bladder augmentation. Excision is curative for pure VAs. Transformation to carcinoma or recurrence has not been reported. However, in one third of the cases, a malignant tumor may accompany the lesion. Therefore, all excision material should be examined carefully. Routine endoscopic follow-up should be performed in cases with bladder augmentation.

show abstract

Benign urethral villous adenoma. Case report

Cited by 6 publications

References 3 publications

Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature

Villous adenoma coexistent with focal well-differentiated adenocarcinoma of female urethral orifice: A case report and review of literature

Adenosquamous carcinoma arising in villous adenoma from female vulvar urethra

Villous adenoma arising in the urethra of a female with bladder augmentation history: a case report and review of the literature

Contact Info

Product

Resources

About