Benign vascular tumors and tumor-like proliferations

Sheth, Sachiv; Lai, Chi; Dry, Sarah M.; Binder, Scott W.; Fishbein, Michael C.

doi:10.1053/j.semdp.2007.10.001

Cited by 15 publications

(9 citation statements)

References 38 publications

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“…The vessels of senile hemangioma are reported to be characterized by both proliferation and dilation [32]–[34]. Thus, it seems to be still unclear whether the tumor is either vascular tumor or malformation.…”

Section: Discussionmentioning

confidence: 99%

Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy

et al. 2010

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BackgroundSenile hemangioma, so-called cherry angioma, is known as the most common vascular anomalies specifically seen in the aged skin. The pathogenesis of its abnormal angiogenesis is still unclear.Methodology/Principal FindingsIn this study, we found that senile hemangioma consisted of clusters of proliferated small vascular channels in upper dermis, indicating that this tumor is categorized as a vascular tumor. We then investigated the mechanism of endothelial proliferation in senile hemangioma, focusing on microRNA (miRNA). miRNA PCR array analysis revealed the mir-424 level in senile hemangioma was lower than in other vascular anomalies. Protein expression of MEK1 and cyclin E1, the predicted target genes of mir-424, was increased in senile hemangioma compared to normal skin or other anomalies, but their mRNA levels were not. The inhibition of mir-424 in normal human dermal microvascular ECs (HDMECs) using specific inhibitor in vitro resulted in the increase of protein expression of MEK1 or cyclin E1, while mRNA levels were not affected by the inhibitor. Specific inhibitor of mir-424 also induced the cell proliferation of HDMECs significantly, while the cell number was decreased by the transfection of siRNA for MEK1 or cyclin E1.Conclusions/SignificanceTaken together, decreased mir-424 expression and increased levels of MEK1 or cyclin E1 in senile hemangioma may cause abnormal cell proliferation in the tumor. Senile hemangioma may be the good model for cutaneous angiogenesis. Investigation of senile hemangioma and the regulatory mechanisms of angiogenesis by miRNA in the aged skin may lead to new treatments using miRNA by the transfection into senile hemangioma.

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Section: Discussionmentioning

confidence: 99%

Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy

et al. 2010

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“…The recent classification by the World Health Organization does not include capillary hepatic haemangioma (HH) but only the cavernous HH [11], which has been recently considered a congenital malformation, even though diagnosis is frequently performed in young adulthood [12]. The radiological term "atypical HH" does not refer to a capillary lesion but exclusively to cavernous HH with possible involutional changes (infarct, necrosis, fibrosis, pedunculations, thrombi, dystrophic calcifications).…”

Section: Discussionmentioning

confidence: 99%

“…In our study, the hyperattenuating lesions were the most frequent, and observed in 29/52 (55%) of cases. Of these, 17 were not associated with THAD (type è riportato; è descritto unicamente il tipo cavernoso [11] di recente considerato malformazione congenita anche se si riscontra nell'adulto [12]. La dizione radiologica EE atipico non è quindi riconducibile ad una lesione vascolare di tipo capillare, ma esclusivamente all'EE cavernoso, eventualmente con alterazioni regressive (infarto, necrosi, fibrosi, forme peduncolate, trombi, calcificazioni distrofiche).…”

Section: Discussionunclassified

Small (≤2 cm) atypical hepatic haemangiomas in the non-cirrhotic patient: pattern-based classification scheme for enhancement at triple-phase helical CT

Scialpi¹,

Volterrani

Mazzei

et al. 2009

Radiol med

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“…[19] Keeping with studies that put hemangioma between 1% and 10%, true incidence may be somewhere midway. [19,20] Age at presentation is different from when lesion was the first noticed. It is the rapid growth of lesion or complications associated with it that form the cause for presentation, so also the treatment.…”

Section: Discussionmentioning

confidence: 99%

Morphological characterization of infantile hemangiomas: An Indian study

Chatura¹,

Nayak²

2016

JMRPS

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Context: Vascular tumors of infancy and childhood consist of a number of clinicopathologically distinct entities. Infantile hemangiomas (IH) constitute the bulk of these tumors. As they are seldom biopsied, we do not encounter an opportunity to study them, and this is evident from the paucity of reported cases in pathology literature from India. Clinicians and pathologists alike have traditionally tended to lump these tumors, under overly generic terms like capillary hemangioma which do little to guide proper clinical management. Aims: To delineate the morphological features that characterize IHs and outline the morphological changes seen in different phases of evolution of this tumor. Subjects and Methods: We characterized 21 cases of IHs over a period of 60-months. Mast cells were counted in 10 fi elds of high density, and mast cell density per square millimeter area was calculated. Results: Female to male ratio was 1:1.6. Head and neck were the most common region involved (71.4%). Morphological features were described. Mast cell density/square millimeter area ranged from 126.9 to 285.7. Spearman correlation coeffi cient was 0.681 (P = 0.676). Statistical Analysis: Spearman correlation coefficient was used to analyze the relationship between mast cell numbers and the age of the lesion. Conclusions: Morphological features seen on routine microscopy can easily help distinguish a lobular capillary hemangioma from an IH or a congenital hemangioma even in the absence of relevant clinical details, pointing to a need for looking beyond using a generic term of capillary hemangioma.

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Benign vascular tumors and tumor-like proliferations

Cited by 15 publications

References 38 publications

Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy

Down-Regulation of mir-424 Contributes to the Abnormal Angiogenesis via MEK1 and Cyclin E1 in Senile Hemangioma: Its Implications to Therapy

Small (≤2 cm) atypical hepatic haemangiomas in the non-cirrhotic patient: pattern-based classification scheme for enhancement at triple-phase helical CT

Morphological characterization of infantile hemangiomas: An Indian study

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