Benigne prostate hyperplasya and adenocarcinoma: the role of signal molecules for diagnostics and therapy in patients of various age

Abstract

In the last years, new data on the role of microenvironment in involution of prostate cells (fibroblasts) and age-associated prostate oncogenesis have been obtained. The goal of this work is the investigation of expression of prostate fibroblasts, CXCL12, SDC1 proteins and hormones in normal and pathological prostate in subjects o different age. Materials were obtained from 78 patients with benignant prostate hyperplasia (BPH), 96 patients with prostate adenocarcinoma and 52 dead men without prostate pathology. All subjects were divided in 3 age groups (middle aged, elderly, and old) and investigated by electron, confocal and light microscopy and immunohistochemical methods. It was shown, that CXCL12 hyperexpression was characteristic of BPH and adenocarcinoma; this correlation became more pronounced with age. SDC1 expression in normal prostate decreased with age which may suggest age-related prostate involution. SDC1 expression in adenocarcinoma increased with. A slight decrease of chromogranin A and somatostatin expression was associated with normal prostate ageing. This process increased in BPH and prostate carcinoma. Chromogranin A and somatostatin decrease correlated with prostate ageing and oncopathology.