Benz-fused mesoionic xanthine analogs as inhibitors of cyclic-AMP phosphodiesterase

A practical synthesis of 2-aminobenzothiazoles via the tandem reactions of 2-haloanilines with isothiocyanates catalyzed by immobilization of copper in MCM-41

“…The mixture was stirred for 24 h at 100 C. Then the solid was filtered and washed by CHCl 3 (2 Â 20 mL), and dried in vacuum at 160 C for 5 h. The dried white solid was then soaked in a solution of 3.1 g of Me 3 SiCl in 100 mL of dry toluene at room temperature under stirring for 24 h. Then the solid was filtered, washed with acetone (3 Â 20 mL) and diethyl ether (3 Â 20 mL), and dried in vacuum at 120 C for 5 h to obtain 3.49 g of hybrid material MCM-41-2N. The nitrogen content was found to be 1.84 mmol/g by elemental analysis.…”

Simple and Efficient Synthesis of Novel Fused Bicyclic Heterocycles Pyrimido-Thiazine and Their Derivatives

“…This type of compounds shows various biological properties such as antibacterial, antiallergic, anti-inflammatory, antitumor, phsphodiesterase inhibition and antiparkinsonism [1][2][3][4][5][6], many workers have synthesized different 1, 3-thiazines [7,8]. Thiazines are very useful units in the fields of medicinal and pharmaceutical chemistry and have been reported to exhibit a variety of biological activities [9,10].…”

Synthesis and Characterization of Fused Pyrimido-pyrimidine Dicarbontriles and their Antibacterial Activity

“…In the last few years researchers have been highly interested in the chemistry of heterocyclic derivatives with their expected biological activity [1][2][3] . Earlier of this fused pyrimido benzothiazole possessing three to four rings [4][5][6] have been reported, which exhibit the activities like Anti-inflammatory 7 , antiallergic 8 , antitumer 9 and antiparakinsonism 10 some pyrimidine derivatives showed antihypertensive, antipyretics, analgesics 11 activity.…”