Benzene‐Associated Leukemia and its Risk Assessment

Kaneko, Takashi; Wang, Peiyu; Sato, Akio

doi:10.1539/joh.39.159

Cited by 7 publications

(2 citation statements)

References 102 publications

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“…According to the evidence of carcinogenicity in humans, the occupational agents are categorized into four groups: i) sufficient evidence, ii) limited evidence, iii) insufficient evidence and iv) lack of evidence of carcinogenicity in humans. Occupational exposure to benzene and its carcinogenicity in humans is wellestablished [1][2][3][4]5) . In 1825, Michael Faraday isolated a new substance from a gas used at that time for illumination.…”

mentioning

confidence: 99%

Story of Benzene and Leukemia: Epidemiologic Approach of Muzaffer Aksoy

Yarış

Dikici

Akbulut³

et al. 2004

Journal of Occupational Health

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The aim of this study is to evaluate his epidemiological approach for his investigation on the effects of benzene and to bring attention to the benzene problem in Turkey. Dr. Aksoy observed that a large group of leukemic patients were shoemakers, or they worked in leather manufacturing. In the 1960s, benzene was a popular solvent in the leather industry. Dr. Aksoy conducted a field investigation in Gedikpasa-Istanbul, where the shoemakers worked so that he could draw his key observations from actual environmental conditions. With a gas detector, he found the concentration of benzene in these work places to be 150-210 ppm and up to 650 ppm on rare occasions. He performed an epidemiological study and health education among 28,500 shoe, slipper and handbag workers during the period from 1967 to 1974. He published these data, establishing an association between benzene and leukemia. The incidence of leukemia among the shoe workers was decreased by screening, health education, and legislative actions in Turkey, but it began to increase again because of lack of an occupational health policy and underestimation of the problem. These results suggest the importance of primary prevention of occupational cancers. Dr. Aksoy's epidemiologic approach may highlight the necessity for detailed investigations of the occupational status of patients who need medical aid in order to diagnose Received Dec 2, 2003; Accepted Jan 19, 2004 Correspondence to: F. Yaris, Karadeniz Technical University, School of Medicine, Department of Family Medicine TR-61187 Trabzon, Turkey (e-mail: fyaris@meds.ktu.edu.tr) the real underlying factor. (J Occup Health 2004; 46: 244-247)

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confidence: 99%

Story of Benzene and Leukemia: Epidemiologic Approach of Muzaffer Aksoy

Yarış

Dikici

Akbulut³

et al. 2004

Journal of Occupational Health

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“…、氯乙烯 [10] 和1,3-丁二烯慢性暴露 [11,12] [14,15] 、俄亥俄州盐酸橡胶工厂工人 [16][17][18][19] 、Dow 化学公司工人 [16,20] 、某地区化工厂男性工人(Wong et al) [21,22] 和中国工人 [23,24]…”

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MCSim-Based Occupational Health Risk Assessment on Benzene

Li¹,

Huang²,

Liu³

2013

JRACR

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Nowadays, the acute and chronic adverse health effects caused by benzene exposure have attracted wide attention. In this paper, we evaluate the health risk based on the four-step method recommended by U.S. Environmental Protection Agency (USEPA). We present a method using the Monte Carlo Simulating Software (MCSim) to build a PBPK model to simulate the concentrations in target tissues of human in distribution forms. The internal dose will be used in the dose-response model to figure out the cancer risk. In the case of workers exposed to benzene in oil refinery workplace, we take the advantage of FLUENT software to simulate the external dose, treat the concentration data by SPSS, and compute the internal dose by MCSim software, so that the lifetime cancer risk range of exposed workers can be calculated if the benzene occupational exposure scenarios are complicated. This method will be used to provide the basis for the occupation health management of enterprises.

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Fractal Analysis of Environmental Contaminants Binding Kinetics on Biosensor Surfaces

Sadana

2005

Fractal Binding and Dissociation Kinetics for Different Biosensor Applications

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Benzene‐Associated Leukemia and its Risk Assessment

Abstract: Abstract:Benzene-Associated

Cited by 7 publications

References 102 publications

Story of Benzene and Leukemia: Epidemiologic Approach of Muzaffer Aksoy

Story of Benzene and Leukemia: Epidemiologic Approach of Muzaffer Aksoy

MCSim-Based Occupational Health Risk Assessment on Benzene

Fractal Analysis of Environmental Contaminants Binding Kinetics on Biosensor Surfaces

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