Benzene exposure induces gut microbiota dysbiosis and metabolic disorder in mice

Sun, Rongli; Xu, Kai; Ji, Shuangbin; Pu, Yunqiu; Man, Zhaodi; Ji, Jiahui; Chen, Minjian; Yin, Lihong; Zhang, Juan; Pu, Yuepu

doi:10.1016/j.scitotenv.2019.135879

Cited by 45 publications

(17 citation statements)

References 54 publications

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“…It is noted that gut flora alterations induced by HFD were attributed to high lipid content in the diet, whereas MSG-induced obese mice in our study were fed on a chow diet, which indicated environmental factors that enter the body through other routes besides gastrointestinal route may also induce intestinal dysbiosis. In this study, MSG can induce the gut microbiota dysbiosis via subcutaneous injection, which is suggested that MSG can transfer into blood to alter the gut microbiota after subcutaneous injection, like benzene ( 45 ).…”

Section: Discussionmentioning

confidence: 90%

Quercetin Ameliorates Gut Microbiota Dysbiosis That Drives Hypothalamic Damage and Hepatic Lipogenesis in Monosodium Glutamate-Induced Abdominal Obesity

et al. 2021

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Monosodium glutamate (MSG)-induced abdominal obesity, conventionally caused by hypothalamic damage, is a critical risk factor for health problem. Microbiota-gut-brain axis plays important roles in a variety of metabolic diseases. However, whether gut microbiota is involved in the pathogenesis for MSG-induced abdominal obesity and the effect of quercetin on it remains unclear. Herein, we find that MSG-induced gut microbiota dysbiosis contributes to neuronal damage in the hypothalamus, as indicated by antibiotics-induced microbiota depletion and co-house treatment. Inspired by this finding, we investigate the mechanism in-depth for MSG-induced abdominal obesity. Liver transcriptome profiling shows retinol metabolism disorder in MSG-induced abdominal obese mice. In which, retinol saturase (RetSat) in the liver is notably up-regulated, and the downstream lipogenesis is correspondingly elevated. Importantly, microbiota depletion or co-house treatment eliminates the difference of RetSat expression in the liver, indicating gut microbiota changes are responsible for liver retinol metabolism disorder. Moreover, this study finds dietary quercetin could modulate MSG-induced gut microbiota dysbiosis, alleviate hypothalamic damage and down-regulate liver RetSat expression, thus ameliorating abdominal obesity. Our study enriches the pathogenesis of MSG-induced abdominal obesity and provides a prebiotic agent to ameliorate abdominal obesity.

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Section: Discussionmentioning

confidence: 90%

Quercetin Ameliorates Gut Microbiota Dysbiosis That Drives Hypothalamic Damage and Hepatic Lipogenesis in Monosodium Glutamate-Induced Abdominal Obesity

et al. 2021

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“…A possible explanation for the variation in the hydroxypentanoate and benzene derivatives between time points and sampling sites could be their relationship to changes in the wound microbiome. Both have previously been shown to be derived from or have an effect on the microbiota [54,55]. However, as the identification of metabolites is only tentative, these results must be taken with caution and further confirmatory studies are necessary.…”

Section: Discussionmentioning

confidence: 91%

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Ashrafi

Muhamadali

et al. 2020

PLoS ONE

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Profiling skin microbiome and metabolome has been utilised to gain further insight into wound healing processes. The aims of this multi-part temporal study in 11 volunteers were to analytically profile the dynamic wound tissue and headspace metabolome and sequence microbial communities in acute wound healing at days 0, 7, 14, 21 and 28, and to investigate their relationship to wound healing, using non-invasive quantitative devices. Metabolites were obtained using tissue extraction, sorbent and polydimethylsiloxane patches and analysed using GCMS. PCA of wound tissue metabolome clearly separated time points with 10 metabolites of 346 being involved in separation. Analysis of variance-simultaneous component analysis identified a statistical difference between the wound headspace metabolome, sites (P = 0.0024) and time points (P<0.0001), with 10 out of the 129 metabolites measured involved with this separation between sites and time points. A reciprocal relationship between Staphylococcus spp. and Propionibacterium spp. was observed at day 21 (P<0.05) with a statistical correlation between collagen and Propionibacterium (r = 0.417; P = 0.038) and Staphylococcus (r = -0.434; P = 0.03). Procrustes analysis showed a statistically significant similarity between wound headspace and tissue metabolome with non-invasive wound devices. This exploratory study demonstrates the temporal and dynamic nature of acute wound metabolome and microbiome presenting a novel class of biomarkers that correspond to wound healing, with further confirmatory studies now necessary.

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“…However, the studies reported the effect of VOCs on intestinal microbiota are rather limited. Sun et al (2020) reported that C57BL/6 mice were exposed to different levels of benzene by subcutaneous injection for 30 days and found that the overall structure of the intestinal microbiome was altered. Exposed to 150 mg/kg benzene, the phylum of Actinobacteria and the genus of Helicobacter were significantly increased in the cecal contents and feces of mice (Sun et al, 2020).…”

Section: Effect Of Volatile Organic Compounds On Intestinal Microbiotamentioning

confidence: 99%

“…Sun et al (2020) reported that C57BL/6 mice were exposed to different levels of benzene by subcutaneous injection for 30 days and found that the overall structure of the intestinal microbiome was altered. Exposed to 150 mg/kg benzene, the phylum of Actinobacteria and the genus of Helicobacter were significantly increased in the cecal contents and feces of mice (Sun et al, 2020). Benzene exposure suppresses the components and functions of immune system of the hosts (Kirkeleit et al, 2006;Bahadar et al, 2014).…”

Section: Effect Of Volatile Organic Compounds On Intestinal Microbiotamentioning

confidence: 99%

Effect of Cigarette Smoke on Gut Microbiota: State of Knowledge

Gui

Yang

2021

Front. Physiol.

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Cigarette smoke is a representative source of toxic chemical exposures to humans, and the adverse consequences of cigarette smoking are mediated by its effect on both neuronal and immune–inflammatory systems. Cigarette smoking also is a major risk factor for intestinal disorders, such as Crohn’s disease and peptic ulcer. On the other hand, cigarette smoking is protective against developing ulcerative colitis. The effects of cigarette smoking on intestinal disorders include changes in intestinal irrigation and microbiome, increases in permeability of the mucosa, and impaired mucosal immune responses. However, the underlying mechanism linking cigarette smoking with intestinal microbiota dysbiosis is largely unknown. In this communication, we first review the current knowledge about the mechanistic interaction between cigarette smoke and intestinal microbiota dysbiosis, which include the likely actions of nicotine, aldehydes, polycyclic aromatic hydrocarbons, heavy metals, volatile organic compounds and toxic gases, and then reveal the potential mechanisms of the lung–gut cross talk and skin-gut cross talk in regulating the balance of intestinal microbiota and the interrelation of intestinal microbiota dysbiosis and systemic disorders.

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Benzene exposure induces gut microbiota dysbiosis and metabolic disorder in mice

Cited by 45 publications

References 54 publications

Quercetin Ameliorates Gut Microbiota Dysbiosis That Drives Hypothalamic Damage and Hepatic Lipogenesis in Monosodium Glutamate-Induced Abdominal Obesity

Quercetin Ameliorates Gut Microbiota Dysbiosis That Drives Hypothalamic Damage and Hepatic Lipogenesis in Monosodium Glutamate-Induced Abdominal Obesity

A microbiome and metabolomic signature of phases of cutaneous healing identified by profiling sequential acute wounds of human skin: An exploratory study

Effect of Cigarette Smoke on Gut Microbiota: State of Knowledge

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