?-Benzene hexachloride in breast adipose tissue and risk of breast carcinoma

Zheng, Tongzhang; Holford, Theodore R.; Mayne, Susan T.; Owens, Pamela L; Ward, Barbara A.; Carter, Darryl; Dubrow, Robert; Zahm, Shelia Hoar; Boyle, Peter; Tessari, John D.

doi:10.1002/(sici)1097-0142(19990515)85:10<2212::aid-cncr16>3.0.co;2-f

Cited by 22 publications

(10 citation statements)

References 18 publications

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“…With the same cohort, Zheng et al (1999b) found no significant differences between lipid-adjusted levels of HCH (lindane) in cases and controls, in contrast to the results of Mussalo-Rauhamaa and Pantzar (1993). The difference in study results may be due to chance (because of the small sample size in the 1993 study), the higher levels of HCH in the earlier study, or the inclusion in the Zheng et al, study of control women with benign breast disease (Zheng et al, 1999b). Further, Zheng et al (2000b) found no increased risk of breast cancer associated with breast adipose levels (lipid basis) of oxychlordane or trans-nonachlor with this cohort.…”

Section: Environmental Chemicals In Breast Tissuecontrasting

confidence: 52%

“…In a study of 304 breast cancer cases and 186 benign breast disease controls in Connecticut, no association was found between breast adipose tissue levels (lipid basis) of DDE or DDT and breast cancer risk (Zheng et al, 1999a). With the same cohort, Zheng et al (1999b) found no significant differences between lipid-adjusted levels of HCH (lindane) in cases and controls, in contrast to the results of Mussalo-Rauhamaa and Pantzar (1993). The difference in study results may be due to chance (because of the small sample size in the 1993 study), the higher levels of HCH in the earlier study, or the inclusion in the Zheng et al, study of control women with benign breast disease (Zheng et al, 1999b).…”

Section: Environmental Chemicals In Breast Tissuementioning

confidence: 81%

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Human breast biomonitoring and environmental chemicals: use of breast tissues and fluids in breast cancer etiologic research

LaKind

Wilkins

Bates

2007

J Expo Sci Environ Epidemiol

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Extensive research indicates that the etiology of breast cancer is complex and multifactorial and may include environmental risk factors. Breast cancer etiology and exposure to xenobiotic compounds, diet, electromagnetic fields, and lifestyle have been the subject of numerous scientific inquiries, but research has yielded inconsistent results. Biomonitoring has been used to explore associations between breast cancer and levels of environmental chemicals in the breast. Research using breast tissues and fluids to cast light on the etiology of breast cancer is, for the most part, predicated on the assumption that the tissue or fluid samples either contain measurable traces of the environmental agent(s) associated with the cancer or that they retain biological changes that are biomarkers of such exposure or precursors of carcinogenic effect. In this paper, we review breast cancer etiology research utilizing breast biomonitoring. We first provide a brief synopsis of the current state of understanding of associations between exposure to environmental chemicals and breast cancer etiology. We then describe the published breast cancer research on tissues and fluids, which have been used for biomonitoring, specifically human milk and its components, malignant and benign breast tissue, nipple aspirate fluid (NAF) and breast cyst fluid. We conclude with a discussion on recommendations for biomonitoring of breast tissues and fluids in future breast cancer etiology research. Both human milk and NAF fluids, and the cells contained therein, hold promise for future biomonitoring research into breast cancer etiology, but must be conducted with carefully delineated hypotheses and a scientifically supportable epidemiological approach.

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Section: Environmental Chemicals In Breast Tissuecontrasting

confidence: 52%

Section: Environmental Chemicals In Breast Tissuementioning

confidence: 81%

Human breast biomonitoring and environmental chemicals: use of breast tissues and fluids in breast cancer etiologic research

LaKind

Wilkins

Bates

2007

J Expo Sci Environ Epidemiol

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“…These differences may partly explain why these previous results were not reproduced here. The lack of association, in our study, of breast cancer risk with serum concentration of HCB or b-HCH is consistent with the majority of previous studies of HCB [29,33,35,37,45,46,49,52,[56][57][58] and b-HCH [17,28,29,31,32,35,41,43,45,47,49,59,60], respectively. Moreover, a recent nested case-control study of HCB in postmenopausal women reported a significant inverse association [42].…”

Section: Discussionmentioning

confidence: 99%

Serum organochlorines and breast cancer risk in Japanese women: a case–control study

Itoh¹,

Iwasaki²,

Hanaoka³

et al. 2008

Cancer Causes Control

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“…However, epidemiologic studies concerning exposure to PCB and breast cancer risk have been controversial. Several earlier studies suggested a positive association [38][39][40][41][42][43][44], other studies showed no increased breast cancer risk [45][46][47][48][49][50]. More recent data suggested that the CYP1A1 m2 polymorphisms might add an increased risk to the etiology of breast cancer in women with environmental exposure to PCBs [51].…”

Section: Polychlorinated Biphenylsmentioning

confidence: 99%

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

Kráľová

Jampílek

2015

Ecological Chemistry and Engineering S

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Breast cancer is the most frequent cancer in women. It is believed that among the causes of breast cancer, hereditary factors account for only 5-10% of risk and the environmental exposures to environmental contaminants account for an additional 30-50% of risk. This paper summarizes findings related to the risk of breast cancer due to exposure to following environmental contaminants: polycyclic aromatic hydrocarbons, polychlorinated biphenyls and dioxins, organochlorine pesticides, organophosphorous pesticides, bisphenol A, phthalates, parabens, organic solvents, atmospheric pollutants, alkylphenols, metals, ionizing radiation, electromagnetic field and light pollution. Results obtained in in vitro experiments with breast cancer cell lines and in vivo with model rodents as well as in population based case-control studies are presented and the mode of action of individual environmental contaminants on mammary gland is discussed. Attention is also devoted to the effects of the timing of exposure to environmental contaminants (mainly exposition during development of the mammary gland) on breast cancer risk. Outcomes of professional exposure to some environmental contaminants on breast cancer risk are analysed as well.

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?-Benzene hexachloride in breast adipose tissue and risk of breast carcinoma

Cited by 22 publications

References 18 publications

Human breast biomonitoring and environmental chemicals: use of breast tissues and fluids in breast cancer etiologic research

Human breast biomonitoring and environmental chemicals: use of breast tissues and fluids in breast cancer etiologic research

Serum organochlorines and breast cancer risk in Japanese women: a case–control study

Impact of Environmental Contaminants on Breast Cancer / Wpływ Zanieczyszczenia Środowiska Na Raka Piersi

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