Benzene in blood and phenol in urine in monitoring benzene exposure in industry

Braier, L; Levy, Ashley A.; Dror, K; Pardo, Asher

doi:10.1002/ajim.4700020206

Cited by 13 publications

(2 citation statements)

References 6 publications

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“…) who had the highest benzene (0.112 mg/dl) and had the highest difference in phenol (22.22 mg/g creatinine) concentrations, was probably exposed to much higher benzene concentrations compared with other workers and was not taken into account. Braler et al [1981] compared phenol in postshift urine and benzene in the blood of workers potentially exposed to a low level of benzene and found normal values of urinary phenol in nearly all workers who had increased benzene concentration in blood. However, the blood benzene concentrations found by them were three to six times lower than those described in this study.…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to benzene in the shoe industry

Karačić

Skender

Prpı́c-Majı́c

1987

American J Industrial Med

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In order to determine the possible actual exposure to benzene in the shoe industry from industrially used solvents, glues, and paints containing benzene as a nondeclared constituent, phenol in urine and benzene in blood, as indices of internal exposure to benzene, were measured in workers (N = 33). Since toluene, in contrast to benzene, is declared as a constituent in several glues, toluene in the blood of workers was also analysed. All analyses were performed using gas chromatography. Urine samples were collected on Monday morning (MI) before work and on Wednesday (WI) before and (WII) after work. Venous blood samples were taken on Wednesday only, 1/2 hour after work. There was no difference in the phenol concentrations of MI and WI, while the phenol concentration of WII was about twice as high as that in WI. In all blood samples, benzene was found, as well as toluene, which was about four times higher in comparison with benzene. A correlation (r = 0.465; p less than .01) was found between the difference in pre- and postshift phenol concentrations (WII-WI) in urine and the benzene concentrations in blood. The results presented show that a trace amount of benzene, which is often not declared as a constitutent in industrially used chemicals, could be a source of marked exposure to benzene. It can also be concluded that changes in phenol in urine (if preshift and postshift samples are taken) might be a sufficiently sensitive parameter to assess exposure to benzene even when other data concerning the presence of benzene in the working atmosphere are not available.

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Section: Discussionmentioning

confidence: 99%

Occupational exposure to benzene in the shoe industry

Karačić

Skender

Prpı́c-Majı́c

1987

American J Industrial Med

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“…The determination of benzene in blood is specific and thus is the method of choice for low levels of exposure to benzene. Since bone marrow retains 20 times as much benzene as the blood at equilibrium, the finding of even low levels of benzene in blood may be of toxicologic significance (4).…”

Section: Benzenementioning

confidence: 99%