Benzeneseleninic Acid

Theoretical Prediction of pKa Values of Seleninic, Selenenic, Sulfinic, and Carboxylic Acids by Quantum-Chemical Methods

“…[1][2][3] Consequently, they have found widespread application as catalysts in oxidation reactions including bromination, 4 especially with hydrogen peroxide. 5,6 Most importantly, the antioxidant activity of selenium compounds is exploited for the protection of cells against oxidative stress, 7 especially as glutathione peroxidase (GPx) mimics, e.g., the anti-inflammatory compound ebselen. 8,9 Seleninic acids had been assumed not to be directly involved in the catalytic cycle but rather be formed by overoxidation and, thus, disrupting the main catalytic pathway.…”

“…Areneseleninic acids, ArSeO 2 H, are moderately strong oxidants that can be reduced to diselenides by a number of reagents. – Consequently, they have found widespread application as catalysts in oxidation reactions including bromination, especially with hydrogen peroxide. , Most importantly, the antioxidant activity of selenium compounds is exploited for the protection of cells against oxidative stress, especially as glutathione peroxidase (GPx) mimics, e.g., the anti-inflammatory compound ebselen. , Seleninic acids had been assumed not to be directly involved in the catalytic cycle but rather be formed by overoxidation and, thus, disrupting the main catalytic pathway . However, recently a revised mechanism for the GPx-like activity of ebselen, involving reversible cyclizations to seleninic and selenenic acids has been proposed, indicating a seleninic acid as the only stable and isolable product in the oxidation of ebselen by peroxides .…”