Benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole scaffolds as potent tumor associated human carbonic anhydrase IX and XII inhibitors

Discovery of Novel Sulfonamide‐Based 5‐Arylidenerhodanines as Effective Carbonic Anhydrase (II) Inhibitors: Microwave‐Assisted and Ultrasound‐Assisted One‐Pot Four‐Component Synthesis, Molecular Docking, and Anti‐CA II Screening Studies

“…For his purpose, a great deal of MW‐based techniques are reported , while only one straightforward US‐mediated synthesis for rhodanines was reported . The based catalyst Knoevenagel reaction leading to the condensation of rhodanines with aldehydes was carried out in separate steps . In this regard, many different catalysts, reaction conditions, and solvents were used.…”

“…2‐Thioxo‐1,3‐thiazolidine‐4‐one skeleton, commonly named as rhodanine, has biological activities with a wide range of picky inhibition on different enzymes such as HCV NS3 protease, β‐lactamase, histidine decarboxylase, aldose reductase, histone acetyltransferase, and N ‐acetyltransferase . Moreover, several heterocylic compounds containing a rhodanine unit display a broad spectrum of pharmacological activities such as antimalarial , antimicrobial , antiviral, anti‐diabetic , and anticonvulsant effects (Fig.…”

Synthesis and Biological Evaluation of Imidazo[2,1-b]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors

“…However, a number of imidazo [2,1-b] [1,3,4]thiadiazole derivatives have been reported to exhibit antitumor activity [7]. Sharma and Supuran et al have reported a series of benzenesulfonamide bearing imidazothiadiazole and thiazolotriazole hybrids as carbonic anhydrases IX and XII inhibitors [8]. The amide derivatives of probenecid have been reported as selective inhibitors of carbonic anhydrase IX and XII by Carradori et al [9,10] (Figure 1).…”

Synthesis and characterization of mixed ligand Cu(II) complexes of 2-methoxy-5-sulfamoylbenzoic acid and 2-aminopyridine derivatives

“…Compounds containing sulfamoyl groups constitute an important class of drugs with several types of pharmacological agents exhibiting antiglaucoma, anticonvulsant, antioxidant, anticholinesterase, antiinflammatory, antibacterial, protease inhibitor and antitumor activity, among others [1][2][3][4][5][6][7][8]. The simple transition metal complex of 2methoxy-5-sulfamoylbenzoic acid (Hsba) has not been synthesized and there are few reports on the synthesis and structural characterization of mixedligand complexes of sulfamoylbenzoic acid derivatives (furosedime [9], 4-sulfamoylbenzoic acid [10,11], 2,4-dichloro-5-sulfamoylbenzoic acid [4]) with other ligands (such as mchlorobenzoic acid [9], nicotinamide [10], di-2pyridylamine [11], 2-aminomethylpyridine [4]).…”