Benzidine Revisited: A Review of the Literature and Problems Associated with the Use of Benzidine and Its Congeners

Haley, Thomas J.

doi:10.3109/15563657508988044

Cited by 153 publications

(40 citation statements)

References 29 publications

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“…Benzidine (BZ) is a urinary bladder carcinogen in humans (64)(65)(66) and dogs (25), and a hepatocarcinogen in rats, mice, and hamsters (66)(67)(68)(69). Since BZ has two amino functions, its metabolic activation pathways are potentially more complicated than the monofunctional aromatic amines.…”

Section: Benzidinementioning

confidence: 99%

Formation and persistence of arylamine DNA adducts in vivo.

Beland¹,

Kadlubar²

1985

Environ Health Perspect

194

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Aromatic amines are urinary bladder carcinogens in man and induce tumors at a number of sites in experimental animals including the liver, mammary gland, intestine, and bladder. In this review, the particular pathways involved in the metabolic activation of aromatic amines are considered as well as the specific DNA adducts formed in target and nontarget tissue. Particular emphasis is placed on the following compounds: 1-naphthylamine, 2-naphthylamine, 4-aminobiphenyl, 4-acetylaminobiphenyl, 4-acetylamino-4'-fluorobiphenyl, 3,2'-dimethyl-4-aminobiphenyl, 2-acetylaminofluorene, benzidine, N-methyl-4-aminoazobenzene, 4-aminoazobenzene, and 2-acetylaminophenanthrene.

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Section: Benzidinementioning

confidence: 99%

Formation and persistence of arylamine DNA adducts in vivo.

Beland¹,

Kadlubar²

1985

Environ Health Perspect

194

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“…Direct Brown showed more urinary BZ compared with BZ group 65) . Therefore, it is difficult to apply the study result that hemoglobin adducts produced through the exposure to DB38 was less than hemoglobin addcuts produced through the exposure to BZ in all BZ dyes.…”

Section: Discussionmentioning

confidence: 99%

Effects of Ethanol and Phenobarbital on Hemoglobin Adducts Formation in Rats Exposed to Benzidine and Direct Black 38

et al. 2009

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“…Like some other genotoxic aromatic amines, benzidine is a bladder carcinogen in humans and induces liver tumors in rodents. In this case, liver tumor formation in mice and rats is obviously predictive for tumor formation in humans in another organ, i.e., the bladder (29,30). However, aromatic amines are genotoxic carcinogens, and their main mode of action is tumor initiation by covalent binding to DNA following metabolic activation (31).…”

Section: Survey Responsementioning

confidence: 99%