Benzimidazole compound abrogates SARS-COV-2 receptor-binding domain (RBD)/ACE2 interaction In vitro

Design, synthesis, molecular docking and molecular dynamic studies of novel benzimidazole–thiazole derivatives as potent and selective COX-2 inhibitors

“…Benzimidazole derivatives have become increasingly important in the past few years due to their diverse range of biological activities. These derivatives have been found to possess many beneficial properties, including anticancer, 19 anti-inflammatory, [20][21][22][23] analgesic, 24 antimicrobial, 25,26 antihelminthic, 27 antiprotozoal, 28 antiviral, 29,30 antifungal, 31 antioxidant, 32,33 antidiabetic, 34 antihistaminic, 35 antitubercular, 36 acetylcholinesterase inhibitor (anti-Alzheimer), 37,38 anti-HIV (Human Immunodefficiency Virus), 39 and anti-hypertensive properties. 40 They have shown promising results in the treatment of various diseases.…”