Benzimidazoles

Preston, Peter N.

doi:10.1002/9780470187159.ch1

Cited by 39 publications

(11 citation statements)

References 627 publications

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“…The chemical structures of the compounds were confirmed by IR, 1 H NMR, 13 C NMR, ESI‐MS, and elemental analysis. IR spectral bands obtained in solid phase at 2400–3200 cm −1 are characteristic of benzimidazole derivatives . According to the IR spectra of the Mannich bases of benzimidazole derivatives having phenolic group, OH and NH stretching bands were observed at 3689–3570 cm −1 and 3474–3232 cm −1 .…”

Section: Resultsmentioning

confidence: 92%

Mannich‐Benzimidazole Derivatives as Antioxidant and Anticholinesterase Inhibitors: Synthesis, Biological Evaluations, and Molecular Docking Study

Alpan

Sarıkaya

Çoban

et al. 2017

Archiv der Pharmazie

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A series of Mannich bases of benzimidazole derivatives having a phenolic group were designed to assess their anticholinesterase and antioxidant activities. The acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory activities were evaluated in vitro by using Ellman's method. According to the activity results, all of the compounds exhibited moderate to good AChE inhibitory activity (except for 2a), with IC values ranging from 0.93 to 10.85 μM, and generally displayed moderate BuChE inhibitory activity. Also, most of the compounds were selective against BuChE. Compound 4b was the most active molecule on the AChE enzyme and also selective. In addition, we investigated the antioxidant effects of the synthesized compounds against FeCl /ascorbic acid-induced oxidative stress in the rat brain in vitro, and the activity results showed that most of the compounds are effective as radical scavengers. Molecular docking studies and molecular dynamics simulations were also carried out.

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Section: Resultsmentioning

confidence: 92%

Mannich‐Benzimidazole Derivatives as Antioxidant and Anticholinesterase Inhibitors: Synthesis, Biological Evaluations, and Molecular Docking Study

Alpan

Sarıkaya

Çoban

et al. 2017

Archiv der Pharmazie

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“…For this reason, good reagents are phosgene [495], urea [496],carbonyldiimidazole [497], dimethyl carbonate [498], N,N-diethylcarbamyl chloride and carbon dioxide [499].…”

Section: 56mentioning

confidence: 99%

Five‐Membered Heterocycles: 1,3‐Azoles

Revuelta¹,

Machetti²,

Cicchi³

2011

Modern Heterocyclic Chemistry

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“…2-(α-hydroxy benzyl) benzimidazole [13,14] In a 500ml of round bottom flask, equimolar amount of o-phenylene diamine (0.01 mol) and Mandelic acid (0.01 mol) were placed. 18 ml of 4n HCL was than added followed by a few porcelain chips and the mixture was refluxed gently on an oil-bath at 135-140 o C for 2 hours.…”

Section: Methodsmentioning

confidence: 99%

Synthesis and biological evaluation of some new benzimidazoles derivatives 4'-{5-amino-2-[2-substituted-phenylamino)-phenyl-methyl]-benzimidazol-1 ylmethyl}-biphenyl-2-carboxylic acid: Nonpeptide angiotensin II receptor antagonists.

Sharma

Kohli

Sharma³

2010

Int j Drug delivery

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A new series of non peptide angiotensin (A-II) receptor antagonist has been prepared. This N-(biphenyl methyl) imidazoles e.g. Some new 4'-{5-amino-2-[2-substituted-phenylamino)-phenyl-methyl]-benzimidazol-1-ylmethyl}-biphenyl-2-carboxylic acid derivatives were synthesized by 2-( α -hydroxy benzyl) benzimidazole was converted to 2-(α-bromo benzyl) benzimidazole by reacting with HBr and Anhydrous ZnCl 2 Schiff bases react with biphenyl carboxylic acid with different substituents amino group cyclocondensation with appropriate reagents. Differ from the previously reported and related compounds in that they produce a potent hypertensive effect. The compounds synthesized were identified by 1 H NMR, 13 C NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for their antihypertensive activity by tail cuff method and direct method measurement of blood pressure.

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Benzimidazoles

Cited by 39 publications

References 627 publications

Mannich‐Benzimidazole Derivatives as Antioxidant and Anticholinesterase Inhibitors: Synthesis, Biological Evaluations, and Molecular Docking Study

Mannich‐Benzimidazole Derivatives as Antioxidant and Anticholinesterase Inhibitors: Synthesis, Biological Evaluations, and Molecular Docking Study

Five‐Membered Heterocycles: 1,3‐Azoles

Synthesis and biological evaluation of some new benzimidazoles derivatives 4'-{5-amino-2-[2-substituted-phenylamino)-phenyl-methyl]-benzimidazol-1 ylmethyl}-biphenyl-2-carboxylic acid: Nonpeptide angiotensin II receptor antagonists.

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