Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Fu, Chenghao; Li, Yuemin; Xi, Hao; Niu, Zemiao; Chen, Ning; Wang, Rong; Yan, Yonghuan; Gan, Xiaoruo; Wang, Mengtian; Zhang, Wei; Zhang, Yan; Lv, Pin

doi:10.3389/fnut.2022.978475

Cited by 18 publications

(10 citation statements)

References 108 publications

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“…In the past years, the exposure to polycyclic aromatic hydrocarbons (PAHs), more specifically to benzo(a)pyrene (BaP), is more common than ever before [ 15 ]. BaP is a crystalline, aromatic hydrocarbon that consists of five fused benzene rings and is formed during the incomplete combustion or pyrolysis of organic matter [ 16 ]. It is primarily found in gasoline and diesel engine exhaust, petroleum asphalt, charcoal-broiled foods, amino acids, fatty acids, and carbohydrate pyrolysis products, among others [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Thyme and Chestnut Honeys Enriched with Bee Products against Benzo(a)pyrene-Induced DNA Damage

Sánchez-Martín

Haza

Iriondo‐DeHond

et al. 2022

IJERPH

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The aim of the present study was to validate the cytotoxicity, genotoxicity, and preventive potential against benzo(a)pyrene (BaP)-induced DNA damage of nine samples of thyme and chestnut honeys enriched with bee products (royal jelly and propolis, 2–10%). Cell viability was determined by the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay (0–250 mg/mL) to select nontoxic concentrations, and DNA damage (0.1–10 μg/mL) was evaluated by the alkaline single-cell gel electrophoresis or comet assay. Treatment with honey samples or royal jelly and propolis did not affect the viability of HepG2 cells up to 100 and 50 mg/mL, respectively. Treatment with 100 μM BaP significantly increased (p ≤ 0.001) the levels of the DNA strand breaks. None of the tested concentrations (0.1–10 μg/mL) of the honey samples (thyme and chestnut), royal jelly, and propolis caused DNA damage per se. All tested samples at all the concentrations used decreased the genotoxic effect of BaP. In addition, all mixtures of thyme or chestnut honeys with royal jelly or propolis showed a greater protective effect against BaP than the samples alone, being the thyme and chestnut honey samples enriched with 10% royal jelly and 10% propolis the most effective (70.4% and 69.4%, respectively). The observed protective effect may be associated with the phenolic content and antioxidant capacity of the studied samples. In conclusion, the thyme and chestnut honey samples enriched with bee products present potential as natural chemoprotective agents against the chemical carcinogen BaP.

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Section: Introductionmentioning

confidence: 99%

Protective Effect of Thyme and Chestnut Honeys Enriched with Bee Products against Benzo(a)pyrene-Induced DNA Damage

Sánchez-Martín

Haza

Iriondo‐DeHond

et al. 2022

IJERPH

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“…Studies on specific feature genes linked to AAA have been published. AHR and its associated signal transduction system are primarily responsible for the inflammatory response, oxidative stress, as well as genetic toxicity of vessel-wall cells 43 . Apelin and its cognate G protein-coupled receptor APLNR constitute a signaling pathway with a positive inotropic effect on cardiac function and a vasodepressor function in the systemic circulation.…”

Section: Discussionmentioning

confidence: 99%

Predicting feature genes correlated with immune infiltration in patients with abdominal aortic aneurysm based on machine learning algorithms

Zhang,

2024

Sci Rep

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Abdominal aortic aneurysm (AAA) is a condition characterized by a pathological and progressive dilatation of the infrarenal abdominal aorta. The exploration of AAA feature genes is crucial for enhancing the prognosis of AAA patients. Microarray datasets of AAA were downloaded from the Gene Expression Omnibus database. A total of 43 upregulated differentially expressed genes (DEGs) and 32 downregulated DEGs were obtained. Function, pathway, disease, and gene set enrichment analyses were performed, in which enrichments were related to inflammation and immune response. AHR, APLNR, ITGA10 and NR2F6 were defined as feature genes via machine learning algorithms and a validation cohort, which indicated high diagnostic abilities by the receiver operating characteristic curves. The cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) method was used to quantify the proportions of immune infiltration in samples of AAA and normal tissues. We have predicted AHR, APLNR, ITGA10 and NR2F6 as feature genes of AAA. CD8 + T cells and M2 macrophages correlated with these genes may be involved in the development of AAA, which have the potential to be developed as risk predictors and immune interventions.

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“…Cigarette smoking is a major source of PAH for the general population (2). Benzo(a)pyrene (BaP), a PAH present in tobacco smoke, has been suggested as the cause of human diseases, including cancers and cardiovascular diseases (3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…Although it has been shown that BaP causes the progression of atherosclerosis, the underlying mechanism remains unclear. Many studies have focused on how BaP exposure can affect the atherosclerotic process (3,(6)(7)(8)(9). Benzo(a)pyrene is a strong aryl hydrocarbon receptor agonist (AhR).…”

Section: Introductionmentioning

confidence: 99%

Aortic Injury Induced by Benzo(a)pyrene and Atherogenic Diet Increased Hepatic FGF21 Expression in C57BL/6J Mice

Shanehbandpour-Tabari,

Gholamnataj,

Neamati

et al. 2024

Iran J Pharm Res

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Background: Benzo(a)pyrene (BaP), an environmental toxicant and endocrine disruptor, has been shown to exacerbate atherosclerosis when combined with a high-fat diet. Fibroblast Growth Factor-21 (FGF21), a novel hormone with anti-atherosclerotic properties, is associated with the presence of atherosclerosis and reduces plaque formation in experimental animals. Objectives: The present study aimed to investigate the chronic effect of BaP injection on hepatic FGF21 expression, as an anti-atherosclerotic hormone, in mice fed with or without an atherogenic diet (AtD). Methods: Eighteen C57BL/6J male mice (6 weeks) were randomly divided into six groups based on the dosage and diet. Blood samples were collected, and serum cholesterol, triglyceride, HDL-C, LDL-C, and glucose levels were measured. FGF21 expression was assessed by quantitative real-time PCR. Atherosclerotic lesions in mice were studied with Oil Red O (ORO) staining. Results: Benzo(a)pyrene causes a significant increase in liver FGF21 expression in a dose-dependent manner, and BaP co-exposure with AtD leads to a further increase in FGF21 expression. Additionally, the addition of BaP to AtD significantly increased the serum glucose, cholesterol, and LDL-C levels and accelerated the formation of atherosclerotic lesions. Besides, our findings showed that there is a significant positive correlation between FGF21 expression and glucose, cholesterol, LDL-C, and ORO-positive areas. Conclusions: Our findings revealed that BaP increases the expression of endogenous FGF21 in treated animals as a compensatory response to protect the heart from atherosclerosis induced by BaP and AtD.

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Benzo(a)pyrene and cardiovascular diseases: An overview of pre-clinical studies focused on the underlying molecular mechanism

Cited by 18 publications

References 108 publications

Protective Effect of Thyme and Chestnut Honeys Enriched with Bee Products against Benzo(a)pyrene-Induced DNA Damage

Protective Effect of Thyme and Chestnut Honeys Enriched with Bee Products against Benzo(a)pyrene-Induced DNA Damage

Predicting feature genes correlated with immune infiltration in patients with abdominal aortic aneurysm based on machine learning algorithms

Aortic Injury Induced by Benzo(a)pyrene and Atherogenic Diet Increased Hepatic FGF21 Expression in C57BL/6J Mice

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