Benzo(a)pyrene enhances atherosclerosis in White Carneau and Show Racer pigeons.

Hough, Jane L.; Baird, Malcolm B.; Sfeir, George T.; Pacini, C S; Darrow, D. I.; Wheelock, Craig E.

doi:10.1161/01.atv.13.12.1721

Cited by 27 publications

(14 citation statements)

References 34 publications

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“…Benzo[a]pyrene (B[a]P), 1 a polycyclic aromatic hydrocarbon present in tobacco smoke, is metabolized in tissue to mutagenic derivatives which form DNA adducts within target cells (4 -6). Considerable experimental evidence suggests that B[a]P accelerates smooth muscle proliferation and promotes atherosclerosis in animals ranging from chickens to rats (7)(8)(9)(10)13). In addition, we and others have detected B[a]P-related DNA adducts in atherosclerotic arteries (11)(12)(13).…”

mentioning

confidence: 99%

Benzo[a]pyrene Induces the Transcription of Cyclooxygenase-2 in Vascular Smooth Muscle Cells

Yan¹,

Subbaramaiah²,

Camilli³

et al. 2000

Journal of Biological Chemistry

100

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mentioning

confidence: 99%

Benzo[a]pyrene Induces the Transcription of Cyclooxygenase-2 in Vascular Smooth Muscle Cells

Yan¹,

Subbaramaiah²,

Camilli³

et al. 2000

Journal of Biological Chemistry

100

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“…The avian PAH study that was selected for TRV derivation was conducted by Hough et al (1993). Three-to six-month-old pigeons were administered a dose of 10 mg/kg BaP (intramuscular) weekly for a period of 5 months.…”

Section: Determining Critical Dietary Concentrationsmentioning

confidence: 99%

“…The evaluation of PAH toxicity to mammals focused on a study by Mackenzie and Angevine (1981) (2003) Toxicity reference value (NOAEL)-PAH mg/kg-day 1.00 Mackenzie and Angevine (1981) 0.143 Hough et al (1993) 1.00 Mackenzie and…”

Section: Determining Critical Dietary Concentrationsmentioning

confidence: 99%

Risk Assessment as a Decision-Making Tool for Treatment of Emissions at a New Aluminum Smelter in Iceland: 3. Ecological Assessment

Salatas

Booth

Gard

et al. 2009

Human and Ecological Risk Assessment: An International Journal

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Predictive ecological risk assessment was used to determine whether any riskreduction benefit would result from the installation and operation of wet scrubbers at an aluminum smelter in East Iceland. Sulfur dioxide and hydrogen fluoride exposure will not result in any appreciable risk to mosses, lichens, lodgepole pine, and heather/heath grassland communities beyond the dilution zone without scrubbers. With scrubbers, exceedances of plant criteria may occur beyond the dilution zone. Critical concentrations of polycyclic aromatic hydrocarbons (PAHs) and hydrogen fluoride (HF) in terrestrial wildlife food items were converted to critical air concentrations, which were then compared to modeled air concentrations. Terrestrial wildlife species are not expected to be exposed to PAH concentrations that result in appreciable risk. If wildlife species are assumed to consume only grasses, predicted HF exposures will not result in exceedance of toxicity thresholds. However, if wildlife species are assumed to consume only heather, thresholds are exceeded at some locations for the rock ptarmigan and wood mouse. Results of population modeling indicate no potential for population impacts to rock ptarmigan outside the facility boundary. Impacts to wood mouse carrying capacity are expected to extend beyond the dilution zone with scrubbers, but not without.

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“…Ramesh aramesh@mmc.edu cascade of biochemical events that involve oxidative stress and inflammation can initiate and accelerate atherosclerosis and aneurysm in experimental animals [2,6]. Kinetics of B(a)P disposition in animal models of atherosclerosis revealed that the slow rate of B(a)P metabolism in arteries coupled with subchronic B(a)P exposure may result in a greater tissue burden of activated metabolites in aortic tissues compared to tissues that metabolize B(a)P more rapidly [7]. The production and accumulation of B(a)P metabolites in aorta trigger the progression of atherosclerotic plaques.…”

Section: Introductionmentioning

confidence: 99%

Metabolism of benzo(a)pyrene by aortic subcellular fractions in the setting of abdominal aortic aneurysms

et al. 2015

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As exposure to polycyclic aromatic hydrocarbons (PAHs; a family of environmental toxicants) have been implicated in cardiovascular diseases, the ability of the aortic tissue to process these toxicants is important from the standpoint of abdominal aortic aneurysms and atherosclerosis. Benzo(a)pyrene (B(a)P), a representative PAH compound is released into the environment from automobile exhausts, industrial emissions, and considerable intake of B(a)P is also expected in people who are smokers and barbecued red meat eaters. Therefore, knowledge of B(a)P metabolism in the cardiovascular system will be of importance in the management of vascular disorders. Toward this end, subcellular fractions (nuclear, cytosolic, mitochondrial, and microsomal) were isolated from the aortic tissues of Apo E mice that received a 5 mg/kg/week of B(a)P for 42 days and 0.71 mg/kg/day for 60 days. The fractions were incubated with 1 and 3 μM B(a)P. Post incubation, samples were extracted with ethyl acetate and analyzed by reverse-phase HPLC. Microsomal B(a)P metabolism was greater than the rest of the fractions. The B(a)P metabolite levels generated by all the subcellular fractions showed a B(a)P exposure concentration-dependent increase for both the weekly and daily B(a)P treatment categories. The preponderance of B(a)P metabolites such as 7,8-dihydrodiol, 3,6-, and 6,12-dione metabolites are interesting due to their reported involvement in B(a)P-induced toxicity through oxidative stress.

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Benzo(a)pyrene enhances atherosclerosis in White Carneau and Show Racer pigeons.

Cited by 27 publications

References 34 publications

Benzo[a]pyrene Induces the Transcription of Cyclooxygenase-2 in Vascular Smooth Muscle Cells

Benzo[a]pyrene Induces the Transcription of Cyclooxygenase-2 in Vascular Smooth Muscle Cells

Risk Assessment as a Decision-Making Tool for Treatment of Emissions at a New Aluminum Smelter in Iceland: 3. Ecological Assessment

Metabolism of benzo(a)pyrene by aortic subcellular fractions in the setting of abdominal aortic aneurysms

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